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- 저자 : Zhao Fengguang (검색결과 2 건)
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Ze-Hua Zhao,Feng-Zhi Xin,Yaqian Xue,Zhimin Hu,Yamei Han,Fengguang Ma,Da Zhou,Xiao-Lin Liu,Aoyuan Cui,Zhengshuai Liu,Yuxiao Liu,Jing Gao,Qin Pan,Yu Li,Jian-Gao Fan 생화학분자생물학회 2019 Experimental and molecular medicine Vol.51 No.-
Microbial metabolites have emerged as critical components that mediate the metabolic effects of the gut microbiota. Here, we show that indole-3-propionic acid (IPA), a tryptophan metabolite produced by gut bacteria, is a potent anti-non-alcoholic steatohepatitis (NASH) microbial metabolite. Here, we demonstrate that administration of IPA modulates the microbiota composition in the gut and inhibits microbial dysbiosis in rats fed a high-fat diet. IPA induces the expression of tight junction proteins, such as ZO-1 and Occludin, and maintains intestinal epithelium homeostasis, leading to a reduction in plasma endotoxin levels. Interestingly, IPA inhibits NF-κB signaling and reduces the levels of proinflammatory cytokines, such as TNFα, IL-1β, and IL-6, in response to endotoxin in macrophages to repress hepatic inflammation and liver injury. Moreover, IPA is sufficient to inhibit the expression of fibrogenic and collagen genes and attenuate diet-induced NASH phenotypes. The beneficial effects of IPA on the liver are likely mediated through inhibiting the production of endotoxin in the gut. These findings suggest a protective role of IPA in the control of metabolism and uncover the gut microbiome and liver cross-talk in regulating the intestinal microenvironment and liver pathology via a novel dietary nutrient metabolite. IPA may provide a new therapeutic strategy for treating NASH.
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Effect of Cr2O3 on the viscosity and structure of slag (or glass) of CaO-MgO-Al2O3-SiO2 system
Wang Yifan,Wang Yici,Zhang Yunhao,Chai Yifan,Zhao Fengguang,Luo Guoping 한국화학공학회 2023 Korean Journal of Chemical Engineering Vol.40 No.7
The glass-ceramics of CaO-MgO-Al2O3-SiO2-Cr2O3 system was prepared by melting method using blast furnace slag, low-carbon ferrochrome alloy slag and quartz sand as raw materials, and the effect of Cr2O3 on the viscosity and structure of slag (or glass) of CaO-MgO-Al2O3-SiO2 (CMAS) system at high temperature was studied. The Urbain viscosity prediction model was established and optimized, and the effect of Cr2O3 on the structure of slag (or glass) was studied by Raman spectroscopy. The results show that when the mass fraction of Cr2O3 is in the range of 0.85–2.05%, the viscosity of slag (or glass) of CMAS system decreases with the increase of Cr2O3 content. The average relative errors between the experimented viscosity value and the calculated viscosity value obtained by using the optimized Urbain model are less than 20%, which is effective and universal for the viscosity prediction of slag (or glass) of CaO-MgO-Al2O3-SiO2-Cr2O3 system. With the increase of Cr2O3 content, the complex silicon oxygen tetrahedrons (Q3) disintegrate into a larger number of simple silicon oxygen tetrahedrons (Q0, Q1, Q2), resulting in the sparse structure of the melt network and a decrease in macroscopic viscosity.
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