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( Yuying Wang ),( Xue Yan ),( Weiwei Zhang ),( Yuanyuan Liu ),( Deping Han ),( Kedao Teng ),( Yunfei Ma ) 한국미생물생명공학회(구 한국산업미생물학회) 2019 Journal of microbiology and biotechnology Vol.29 No.6
Farm animals such as piglets are often affected by environmental stress, which can disturb the gut ecosystem. Antibiotics were commonly used to prevent diarrhea in weaned piglets, but this was banned by the European Union due to the development of antibiotic resistance. However, the use of probiotics instead of antibiotics may reduce the risk posed by pathogenic microorganisms and reduce the incidence of gastrointestinal diseases. Therefore, this study was conducted to investigate the effects of Lactobacillus casei Zhang on the mechanical barrier and immune function of early-weaned piglets infected using Escherichia coli K88 based on histomorphology and immunology. Fourteen-day-old weaned piglets were divided into a control group and experimental groups that were fed L. casei Zhang and infected with E. coli K88 with or without prefeeding and/or postfeeding of L. casei Zhang. The L. casei Zhang dose used was 107 CFU/g diet. Jejunum segments were obtained before histological, immunohistochemical, and western blot analyses were performed. In addition, the relative mRNA expression of toll receptors and cytokines was measured. Piglets fed L. casei Zhang showed significantly increased jejunum villus height, villus height-crypt depth ratio, muscle thickness, and expression of proliferating cell nuclear antigen and tight junction proteins ZO-1 and occludin. The use of L. casei Zhang effectively reduced intestinal inflammation after infection. We found that L. casei Zhang feeding prevented the jejunum damage induced by E. coli K88, suggesting that it may be a potential alternative to antibiotics for preventing diarrhea in early-weaned piglets.
Liu1 Ruijuan,Liu Chunyan,Zhang Zihou 경남대학교 기초과학연구소 2019 Nonlinear Functional Analysis and Applications Vol.24 No.1
Let C be a closed bounded convex subset of a real Banach space X with 0 as its interior point and pc the Minkowski functional generated by the set C. For a nonempty set G in X and x ∈ X, g_0 ∈ G is called the generalized best approximation to x from G if p_c(g_0 − x) ≤ p_c(g − x) for all g ∈ G. In this paper, we will give a distance formula under p_C from a point to a half-space K_{x^∗_0,c} = {x ∈ X : x^∗_0(x) ≤ c} in Banach space and investigate the continuity of this generalized metric projection, extending corresponding results for the case of norm.
Fuqi Zhang1,Pingping Xiao,Yujia Liu 한국전자통신연구원 2022 ETRI Journal Vol.44 No.4
H2RDC (heuristic handover based on RCC-DTSK-C), a heuristic algorithm based on a highly interpretable deep Takagi–Sugeno–Kang fuzzy classifier, is proposed for suppressing the mobile heterogeneous networks problem of frequent handover and handover ping-pong in the multibase-station scenario. This classifier uses a stack structure between subsystems to form a deep classifier before generating a base station (BS) priority sequence during the handover process, and adaptive handover hysteresis is calculated. Simulation results show that H2RDC allows user equipment to switch to the best antenna at the optimal time. In high-BS density load and mobility scenarios, the proposed algorithm’s handover success rate is similar to those of classic algorithms such as best connection (BC), self tuning handover algorithm (STHA), and heuristic for handover based on AHP-TOPSIS-FUZZY (H2ATF). Moreover, the handover rate is 83% lower under H2RDC than under BC, whereas the handover ping-pong rate is 76% lower.
A New ent-Kaurane type Diterpenoid Glycoside from Inula japonica Thunb
Jiang Jiang Qin,Jia Xian Zhu,Wei Dong Zhang1,2,Yan Zhu,Jian Jun Fu,Xiao Hua Liu,Hui Zi Jin 대한약학회 2009 Archives of Pharmacal Research Vol.32 No.10
A new ent-kaurane type diterpenoid glycoside, 17-O-β-D-glucopyranosyl-16α-ent-kauran-19-oic acid (1), together with 17-hydroxy-16α-ent-kauran-19-oic acid (2), 16α,17-dihydroxyl-ent-kauran-19-oic acid (3), and 16α-hydroxy-17-acetoxy-ent- kauran-19-oic acid (4) were isolated from the aerial parts of Inula japonica Thunb. The structure of 1 was determined mainly by use of 1D and 2D NMR spectroscopic techniques including HSQC, 1H-1H COSY, HMBC, and NOESY. In addition, 4 exhibited significant inhibitory activity on NO production in LPS-stimulated RAW264.7 cells with IC50 value of 14.3 μg/mL.
Zhang, Chun-Xing,Liang, Long,Zhang, Bin,Chen, Wen-Bo,Liu, Hong-Jun,Liu, Chun-Ling,Zhou, Zheng-Gen,Liang, Chang-Hong,Zhang, Shui-Xing Asian Pacific Journal of Cancer Prevention 2015 Asian Pacific journal of cancer prevention Vol.16 No.8
Background: This study was conducted to analyze positron emission tomography (PET) / computed tomography (CT) and magnetic resonance imaging (MRI) performance with oropharyngeal non-Hodgkin's lymphoma (ONHL).Materials and Methods: The complete image data of 30 ONHL cases were analyzed, all patients were performed PET / CT and MRI examination before the treatment, with the time interval of these two inspections not exceeding 14 days. The distribution, morphology, MRI signal characteristics, enhancement feature, standardized uptake value (SUV) max value and lymph node metastasis way of the lesions were analyzed. Results: Among the 30 cases, 23 cases were derived from the B-cell (76.7%), 5 cases were derived from the peripheral T cells (16.7%) and 2 cases were derived from the NK/T cells (6.7%). 19 cases exhibited the palatine tonsil involvement (63.3%). As for the lesion appearance, 10 cases appeared as mass, 8 cases were the diffused type and 12 cases were the mixed type. 25 cases exhibited the SUVmax value of PET / CT primary lesions as 11 or more (83.3%). MRI showed that all patients exhibited various degrees of parapharyngeal side-compressed narrowing, but MRI still exhibited the high-signal fat, and the oropharyngeal mucosa was intact. 25 cases were associated with the neck lymph node metastasis, among who 22 cases had no necrosis in the metastatic lymph nodes, while the rest 3 cases exhibited the central necrosis in the metastatic lymph nodes. Conclusions: PET / CT and MRI have important value in diagnosing and determining the lesion extent of ONHL.
Hybrid Patterns Recognition of Control Chart Based on WA-PCA-PSO-SVM
Liu Yan-zhong,Zhang Hong-lie,Liu Yan-ju,Jiang Jin-gang 보안공학연구지원센터 2014 International Journal of Control and Automation Vol.7 No.10
Based on the analysis of the defect of traditional model, this paper proposes a new control chart pattern recognition model, which includes Wavelet Analysis (WA), Principal Component Analysis (PCA), Particle Swarm Optimization (PSO) and Support Vector Machine (SVM). WA is good to eliminate noise control chart anomaly pattern recognition of the adverse effect. PCA eliminates the redundant information of data between SVM and reduces the input dimension and computational complexity. PSO algorithm optimizes the parameters of SVM and the establishment of the optimal control chart anomaly pattern classifier can solve the problem optimal parameters of SVM. The simulation results show that the model is feasible, the results are reliable. This algorithm improves the control chart abnormal state average recognition accuracy and be used in the machining process real-time monitoring.
Zhang Wentao,Zheng Zongtai,Wang Keyi,Mao Weipu,Li Xue,Wang Guangchun,Zhang Yuanyuan,Huang Jianhua,Zhang Ning,Wu Pengfei,Liu Ji,Zhang Haimin,Che Jianping,Peng Bo,Zheng Junhua,Li Wei,Yao Xudong 생화학분자생물학회 2023 Experimental and molecular medicine Vol.55 No.-
Accumulating studies have confirmed that PIWI-interacting RNAs (piRNAs) are considered epigenetic effectors in cancer. We performed piRNA microarray expression analysis on renal cell carcinoma (RCC) tumor tissues and paired normal tissues and performed a series of in vivo and in vitro experiments to explore piRNAs associated with RCC progression and investigate their functional mechanisms. We found that piR-1742 was highly expressed in RCC tumors and that patients with high piR-1742 expression had a poor prognosis. Inhibition of piR-1742 significantly reduced tumor growth in RCC xenograft and organoid models. Mechanistically, piRNA-1742 regulates the stability of USP8 mRNA by binding directly to hnRNPU, which acts as a deubiquitinating enzyme that inhibits the ubiquitination of MUC12 and promotes the development of malignant RCC. Subsequently, nanotherapeutic systems loaded with piRNA-1742 inhibitors were found to effectively inhibit the metastasis and growth of RCC in vivo. Therefore, this study highlights the functional importance of piRNA-related ubiquitination in RCC and demonstrates the development of a related nanotherapeutic system, possibly contributing to the development of therapeutic approaches for RCC.
Liu, Ming,Pan, Hong,Zhang, Feng,Zhang, Yong-Biao,Zhang, Yang,Xia, Han,Zhu, Jing,Fu, Wei-Ling,Zhang, Xiao-Li Asian Pacific Journal of Cancer Prevention 2013 Asian Pacific journal of cancer prevention Vol.14 No.11
Background: To further investigate the molecular basis of lung cancer development, we utilize a microarray to identify differentially expressed genes associated with various TNM stages of adenocarcinoma, a subtype with increasing incidence in recent years in China. Methods: A 35K oligo gene array, covering about 25,100 genes, was used to screen differentially expressed genes among 90 tumor samples of lung adenocarcinoma in various TNM stages. To verify the gene array data, three genes (Zimp7, GINS2 and NAG-1) were confirmed by real-time RT-PCR in a different set of samples from the gene array. Results: First, we obtained 640 differentially expressed genes in lung adenocarcinomas compared to the surrounding normal lung tissues. Then, from the 640 candidates we identified 10 differentially expressed genes among different TNM stages (Stage I, II and IIIA), of which Zimp7, GINS2 and NAG-1 genes were first reported to be present at a high level in lung adenocarcinoma. The results of qRT-PCR for the three genes were consistent with those from the gene array. Conclusions: We identified 10 candidate genes associated with different TNM stages in lung adenocarcinoma in the Chinese population, which should provide new insights into the molecular basis underlying the development of lung adenocarcinoma and may offer new targets for the diagnosis, therapy and prognosis prediction.
Zhang, Qing,Zhang, Xingyuan,Zhang, Wencheng,Pan, Jian,Liu, Ling,Zhang, Haitao,Zhao, Dong,Li, Zhi Korean Chemical Society 2011 Bulletin of the Korean Chemical Society Vol.32 No.9
Oleanolic acid (OA) as template molecule, polyamide-6 (PA6) as basement membrane and poly(styrene-comaleic acid) (PSMA) were used to prepare PA6/PSMA-OA molecularly imprinted composite membranes by phase inversion method in supercritical $CO_2$ ($ScCO_2$). The template molecule (OA), [poly(styrene-co-maleic anhydride) (PSMAH), PSMA, molecularly imprinted membranes (MIMs) imprinting OA and MIMs after elution were all characterized by Fourier transform infrared spectroscopy (FTIR). The conditions that were the mass ratio between PSMA and OA from 3:1 to 8:1, temperature of $ScCO_2$ from $35^{\circ}C$ to $50^{\circ}C$ and pressure of $ScCO_2$ 12 MPa to 17 MPa were studied. It was obtained the largest adsorption rate and purity of OA after adsorption of the resultant MIMs, 50.41% and 96.15% respectively. After using PA6 film and non-woven fabrics as basement membrane respectively, it was found that smaller aperture of PA6 was used as basement membrane, a higher adsorption rate and a higher purity of OA after adsorption of the MIMs were obtained, and so were the stability and reproducibility of the resultant MIMs. After template molecules being removed, the MIMs had effective selectivity hydrogen bonding to separately bind in the binary components to the template molecules-oleanolic acid.
Liu, Yuhang,Liu, Xiangxin,Zhang, Jianwei,Zhang, Yufeng,Liu, Guangchen The Korean Institute of Power Electronics 2021 JOURNAL OF POWER ELECTRONICS Vol.21 No.9
This paper proposes a novel maximum power point tracking (MPPT) algorithm for a thin-film photovoltaic (PV) module with a flexible step-up DC-DC converter. To improve the voltage rating for the thin film module, a switch-inductor zero voltage transition (SIZVT) boost converter is proposed. In addition, the proposed methodology uses a multistage variable step size (MVSS) with a power close-loop control strategy (PCLC) for MPPT. The corresponding performances are compared with the classical fixed step size (FSS) algorithm and the conventional variable step size (CVSS) algorithm. Simulation results in MATLAB/Simulink and experimental tests with a 240 W prototype validate the proposed algorithm under a variety of conditions.