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Ze-Hua Zhou,Ce-Zhong Tong 대한수학회 2014 대한수학회지 Vol.51 No.1
We study the compact intertwining relations for composition operators, whose intertwining operators are Volterra type operators from the weighted Bergman spaces to the weighted Bloch spaces in the unit disk. As consequences, we find a new connection between the weighted Bergman spaces and little weighted Bloch spaces through this relations.
Ze-Hua Zhao,Feng-Zhi Xin,Yaqian Xue,Zhimin Hu,Yamei Han,Fengguang Ma,Da Zhou,Xiao-Lin Liu,Aoyuan Cui,Zhengshuai Liu,Yuxiao Liu,Jing Gao,Qin Pan,Yu Li,Jian-Gao Fan 생화학분자생물학회 2019 Experimental and molecular medicine Vol.51 No.-
Microbial metabolites have emerged as critical components that mediate the metabolic effects of the gut microbiota. Here, we show that indole-3-propionic acid (IPA), a tryptophan metabolite produced by gut bacteria, is a potent anti-non-alcoholic steatohepatitis (NASH) microbial metabolite. Here, we demonstrate that administration of IPA modulates the microbiota composition in the gut and inhibits microbial dysbiosis in rats fed a high-fat diet. IPA induces the expression of tight junction proteins, such as ZO-1 and Occludin, and maintains intestinal epithelium homeostasis, leading to a reduction in plasma endotoxin levels. Interestingly, IPA inhibits NF-κB signaling and reduces the levels of proinflammatory cytokines, such as TNFα, IL-1β, and IL-6, in response to endotoxin in macrophages to repress hepatic inflammation and liver injury. Moreover, IPA is sufficient to inhibit the expression of fibrogenic and collagen genes and attenuate diet-induced NASH phenotypes. The beneficial effects of IPA on the liver are likely mediated through inhibiting the production of endotoxin in the gut. These findings suggest a protective role of IPA in the control of metabolism and uncover the gut microbiome and liver cross-talk in regulating the intestinal microenvironment and liver pathology via a novel dietary nutrient metabolite. IPA may provide a new therapeutic strategy for treating NASH.
A High-efficiency Trim Method for CFD Numerical Calculation of Helicopter Rotors
Zhou Ye,Guo-hua Xu,Yong-jie Shi,Run-ze Xia 한국항공우주학회 2017 International Journal of Aeronautical and Space Sc Vol.18 No.2
In order to resolve the trimming difficulty in rotor CFD calculations, a high-efficiency and improved “delta trim method” is established to compute the blade control settings that are necessary to identify the blade motion. In this method, a simplified model which combines the blade element theory and different inflow models is employed to calculate the control settings according to the target aerodynamic forces, then it is coupled into a CFD solver with unsteady Navier-Stokes equations by the delta methodology, which makes the control settings and aerodynamics calculated and updated in the meantime at every trim cycle. Different from the previous work, the current research combines the inflow model based on prescribed wake theory. Using the method established, the control settings and aerodynamic characteristics of Helishape 7A, AH-1G and Caradonna-Tung rotors are calculated. The influence of different inflow models on trimming calculations is analyzed and the computational efficiency of the current “delta trim method” is compared with that of the “CFD-based trim method”. Furthermore, for the sake of improving the calculation efficiency, a novel acceleration factor method is introduced to accelerate the trimming process. From the numerical cases, it is demonstrated that the current “delta trim method” has higher computational efficiency than “CFD-based trim method” in both hover and forward flight, and up to 70% of the amount of calculation can be saved by current “delta trim method” which turns out to be satisfactory for engineering applications. In addition, the proposed acceleration factor shows a good ability to accelerate the trim procedure, and the prescribed wake inflow model is always of better stability than other simple inflow models whether the acceleration factor is utilized in trimming calculations.
NORMAL COMPLEX SYMMETRIC WEIGHTED COMPOSITION OPERATORS ON THE HARDY SPACE
Zhou, Hang,Zhou, Ze-Hua Korean Mathematical Society 2021 대한수학회지 Vol.58 No.4
In this paper, we investigate the normal and complex symmetric weighted composition operators W<sub>𝜓,𝜑</sub> on the Hardy space H<sup>2</sup>(𝔻). Firstly, we give the explicit conditions of weighted composition operators to be normal and complex symmetric with respect to conjugations 𝒞<sub>1</sub> and 𝒞<sub>2</sub> on H<sup>2</sup>(𝔻), respectively. Moreover, we particularly investigate the weighted composition operators W<sub>𝜓,𝜑</sub> on H<sup>2</sup>(𝔻) which are normal and complex symmetric with respect to conjugations 𝓙, 𝒞<sub>1</sub> and 𝒞<sub>2</sub>, respectively, when 𝜑 has an interior fixed point, 𝜑 is of hyperbolic type or parabolic type.
Da Zhou,Yuan-Wen Chen,Ze-Hua Zhao,Rui-Xu Yang,Feng-Zhi Xin,Xiao-Lin Liu,Qin Pan,Huiping Zhou,Jian-Gao Fan 생화학분자생물학회 2018 Experimental and molecular medicine Vol.50 No.-
Glucagon-like peptide-1 (GLP-1) has a broad spectrum of biological activity by regulating metabolic processes via both the direct activation of the class B family of G protein-coupled receptors and indirect nonreceptor-mediated pathways. GLP-1 receptor (GLP-1R) agonists have significant therapeutic effects on non-alcoholic fatty liver disease (NAFLD) and steatohepatitis (NASH) in animal models. However, clinical studies indicated that GLP-1 treatment had little effect on hepatic steatosis in some NAFLD patients, suggesting that GLP-1 resistance may occur in these patients. It is wellknown that the gut metabolite sodium butyrate (NaB) could promote GLP-1 secretion from intestinal L cells. However, it is unclear whether NaB improves hepatic GLP-1 responsiveness in NAFLD. In the current study, we showed that the serum GLP-1 levels of NAFLD patients were similar to those of normal controls, but hepatic GLP-1R expression was significantly downregulated in NAFLD patients. Similarly, in the NAFLD mouse model, mice fed with a high-fat diet showed reduced hepatic GLP-1R expression, which was reversed by NaB treatment and accompanied by markedly alleviated liver steatosis. In addition, NaB treatment also upregulated the hepatic p-AMPK/p-ACC and insulin receptor/ insulin receptor substrate-1 expression levels. Furthermore, NaB-enhanced GLP-1R expression in HepG2 cells by inhibiting histone deacetylase-2 independent of GPR43/GPR109a. These results indicate that NaB is able to prevent the progression of NAFL to NASH via promoting hepatic GLP-1R expression. NaB is a GLP-1 sensitizer and represents a potential therapeutic adjuvant to prevent NAFL progression to NASH.
A High-efficiency Trim Method for CFD Numerical Calculation of Helicopter Rotors
Ye, Zhou,Xu, Guo-hua,Shi, Yong-jie,Xia, Run-ze The Korean Society for Aeronautical and Space Scie 2017 International Journal of Aeronautical and Space Sc Vol.18 No.2
In order to resolve the trimming difficulty in rotor CFD calculations, a high-efficiency and improved "delta trim method" is established to compute the blade control settings that are necessary to identify the blade motion. In this method, a simplified model which combines the blade element theory and different inflow models is employed to calculate the control settings according to the target aerodynamic forces, then it is coupled into a CFD solver with unsteady Navier-Stokes equations by the delta methodology, which makes the control settings and aerodynamics calculated and updated in the meantime at every trim cycle. Different from the previous work, the current research combines the inflow model based on prescribed wake theory. Using the method established, the control settings and aerodynamic characteristics of Helishape 7A, AH-1G and Caradonna-Tung rotors are calculated. The influence of different inflow models on trimming calculations is analyzed and the computational efficiency of the current "delta trim method" is compared with that of the "CFD-based trim method". Furthermore, for the sake of improving the calculation efficiency, a novel acceleration factor method is introduced to accelerate the trimming process. From the numerical cases, it is demonstrated that the current "delta trim method" has higher computational efficiency than "CFD-based trim method" in both hover and forward flight, and up to 70% of the amount of calculation can be saved by current "delta trim method" which turns out to be satisfactory for engineering applications. In addition, the proposed acceleration factor shows a good ability to accelerate the trim procedure, and the prescribed wake inflow model is always of better stability than other simple inflow models whether the acceleration factor is utilized in trimming calculations.
NEW CHARACTERIZATIONS OF COMPOSITION OPERATORS BETWEEN BLOCH TYPE SPACES IN THE UNIT BALL
Zhong-Shan Fang,Ze-Hua Zhou 대한수학회 2015 대한수학회보 Vol.52 No.3
In this paper, we give new characterizations of the boundedness and compactness of composition operators C between Bloch type spaces in the unit ball Bⁿ, in terms of the power of the components of , where is a holomorphic self-map of Bⁿ.
HEREDITARILY HYPERCYCLICITY AND SUPERCYCLICITY OF WEIGHTED SHIFTS
Liang, Yu-Xia,Zhou, Ze-Hua Korean Mathematical Society 2014 대한수학회지 Vol.51 No.2
In this paper we first characterize the hereditarily hypercyclicity of the unilateral (or bilateral) weighted shifts on the spaces $L^2(\mathbb{N},\mathcal{K})$ (or $L^2(\mathbb{Z},\mathcal{K})$) with weight sequence {$A_n$} of positive invertible diagonal operators on a separable complex Hilbert space $\mathcal{K}$. Then we give the necessary and sufficient conditions for the supercyclicity of those weighted shifts, which extends some previous results of H. Salas. At last, we give some conditions for the supercyclicity of three different weighted shifts.
HEREDITARILY HYPERCYCLICITY AND SUPERCYCLICITY OF WEIGHTED SHIFTS
Yu-Xia Liang,Ze-Hua Zhou 대한수학회 2014 대한수학회지 Vol.51 No.2
In this paper we first characterize the hereditarily hyper- cyclicity of the unilateral (or bilateral) weighted shifts on the spaces L² (N,K) (or L²(Z,K)) with weight sequence {An} of positive invert- ible diagonal operators on a separable complex Hilbert space K. Then we give the necessary and sufficient conditions for the supercyclicity of those weighted shifts, which extends some previous results of H. Salas. At last, we give some conditions for the supercyclicity of three different weighted shifts.