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Zai-Song Ding,Su-Hua Huang,Bao-Yuan Zhou,Xue-Fang Sun,Ming Zhao 한국식물생명공학회 2013 Plant biotechnology reports Vol.7 No.2
Phosphoenolpyruvate carboxylase (PEPC) catalyzesthe initial fixation of CO2 in C4 plants. Under thecontrol of the rice Rubisco small subunit promoter, cDNAof a C4 SiPPC gene cloned from Seteria italica wasintroduced into Japonica rice by Agrobacterium-mediatedtransformation. Integration of the gene was confirmed byPCR analysis. RT-PCR showed expression of the gene atthe RNA level in transgenic plants, and enzyme activitymeasurements confirmed the increase in PEPC protein. Thetransformants showed improvements in both photosynthesisrate and yield only under upland field cultivation. Thepossible function of PEPC in rice stress tolerance isdiscussed.
Ding, Zai-Song,Huang, Su-Hua,Zhou, Bao-Yuan,Sun, Xue-Fang,Zhao, Ming 한국식물생명공학회 2013 Plant biotechnology reports Vol.7 No.2
Phosphoenolpyruvate carboxylase (PEPC) catalyzes the initial fixation of $CO_2$ in $C_4$ plants. Under the control of the rice Rubisco small subunit promoter, cDNA of a $C_4$ SiPPC gene cloned from Seteria italica was introduced into Japonica rice by Agrobacterium-mediated transformation. Integration of the gene was confirmed by PCR analysis. RT-PCR showed expression of the gene at the RNA level in transgenic plants, and enzyme activity measurements confirmed the increase in PEPC protein. The transformants showed improvements in both photosynthesis rate and yield only under upland field cultivation. The possible function of PEPC in rice stress tolerance is discussed.
On the minimum weight of a 3-connected 1-planar graph
Zai Ping Lu,Ning Song 대한수학회 2017 대한수학회보 Vol.54 No.3
A graph is called \emph{$1$-planar} if it can be drawn in the Euclidean plane $\mathbb{R}^2$ such that each edge is crossed by at most one other edge. The \emph{weight} of an edge is the sum of degrees of two ends. It is known that every planar graph of minimum degree $\delta\ge3$ has an edge with weight at most $13$. In the present paper, we show the existence of edges with weight at most $25$ in $3$-connected $1$-planar graphs.
임신토끼에 있어서 새로운 Recombinant Human Granulocyte Colony - Stimulating Factor ( YHB6211 ) 의 배 , 태자 발생독성평가
황재식(Zai Zhi Huang),이수해(Su Hae Lee),신지순(Ji Soon Sin),신장우(Jang Woo Sin),최연식(Yeon Shik Choi),김대중(Dae Joong Kim),장호송(Hu Song Zhang),정은용(Eun Yong Jung),서동석(Dong Suk Seo),안경규(Kyoung Kyu Ahn),남상윤(Sang Yoon N 한국응용약물학회 2001 Biomolecules & Therapeutics(구 응용약물학회지) Vol.9 No.4
N/A YHB6211, a newly developed recombinant human granulocyte colonystimulating factor, was administered at dose levels of 0, 3, 15, and 75 ㎍/㎏/day intravenously to the pregnant New Zealand White rabbits (20 rabbits per group) during the organogenetic period, days 6 to 18 of gestation. All dams were subjected to Caesarian section on day 28 of gestation and their fetuses were examined for external, visceral, and skeletal abnormalities. No abnormalities in clinical signs, body weight changes, gross findings, mortality, and external appearance were found in all dams and fetuses exposed to 0, 3, and 15 ㎍/㎏/day of YHB6211. However, in the group treated with 75 ㎍/㎏/day of YHB6211, maternal body and uterine weights, fetal body weights and length, and the number of live fetuses were significantly decreased and further fetal mortality was remarkably increased. It is suggested that YHB6211 may have no side effect up to the dose level of 15 ㎍/㎏/day, and there would be no teratogenicity for fetuses of rabbits up to 75 ㎍/㎏/day even if it may have some toxic effects over 75 ㎍/㎏/day for dams and fetuses of rabbits.
ON THE MINIMUM WEIGHT OF A 3-CONNECTED 1-PLANAR GRAPH
Lu, Zai Ping,Song, Ning Korean Mathematical Society 2017 대한수학회보 Vol.54 No.3
A graph is called 1-planar if it can be drawn in the Euclidean plane ${\mathbb{R}}^2$ such that each edge is crossed by at most one other edge. The weight of an edge is the sum of degrees of two ends. It is known that every planar graph of minimum degree ${\delta}{\geq}3$ has an edge with weight at most 13. In the present paper, we show the existence of edges with weight at most 25 in 3-connected 1-planar graphs.
Thirteen-Week Safety Evaluation on Meat Products of Somatic Cell-Cloned Cows in Rats
Young Min Cho,Ji-Soon Sin,Sun-Hee Kim,Hee-Youl Chai,Woon Kwon,Ehn-Kyoung Choi,Hu-Song Zhang,Zai-Zhi Huang,Mei-Shu Zheng,Hyeong-Jin Ji,Yong-Woo Roh,Yun-Bae Kim,Jong-Koo Kang 한국실험동물학회 2003 한국실험동물학회 학술발표대회 논문집 Vol.2003 No.-
새로운 간질환치료제(고덱스 : 헤파디프에스)의 랫드에 대한 4주반복투여 경구독성시험
강종구(Jong-Kii Kang),정은용(Eun-Yong Jung),박선희(Sun-Hee Park),김선희(Sun-Hee Kim),이수해(Su-Hae Lee),장호송(Hu-Song Zhang),황재식(Zai-Zhi Huang),남상윤(Sang-Yoon Nam) 한국독성학회 2001 Toxicological Research Vol.17 No.2
This study was designed to evaluate a repeated oral dose toxicity of a new hepatotherapeutic agent GODEX in Sprague-Dawley rats. Male and female rats were orally administered with dosages of 500, 100, 20, and a mg/kg/day of GODEX daily for 4 weeks, respectively. There were no dose-related changes in clinical signs, body weight changes, food and water consumption, opthalmoscopy, organ weights, urine analysis, biochemical examination, and hematological findings of all animals treated with GODEX. Gross and histopathological findings revealed no evidence of specific toxicity related to GODEX. These indicate that GODEX may have no side effects and its oral maximum tolerated dose value may be over 500 mg/kg in rats.
Wang Lu,Dai Ying-Jie,Cui Yu,Zhang Hong,Jiang Chang-Hao,Duan Ying-Jie,Zhao Yong,Feng Ye-Fang,Geng Shi-Mei,Zhang Zai-Hui,Lu Jiang,Zhang Ping,Zhao Li-Wei,Zhao Hang,Ma Yu-Tong,Song Cheng-Guang,Zhang Yi,Ch 대한뇌졸중학회 2023 Journal of stroke Vol.25 No.3
Background and Purpose Intravenous tenecteplase (TNK) efficacy has not been well demonstrated in acute ischemic stroke (AIS) beyond 4.5 hours after onset. This study aimed to determine the effect of intravenous TNK for AIS within 4.5 to 24 hours of onset. Methods In this pilot trial, eligible AIS patients with diffusion-weighted imaging (DWI)-fluid attenuated inversion recovery (FLAIR) mismatch were randomly allocated to intravenous TNK (0.25 mg/kg) or standard care within 4.5–24 hours of onset. The primary endpoint was excellent functional outcome at 90 days (modified Rankin Scale [mRS] score of 0–1). The primary safety endpoint was symptomatic intracranial hemorrhage (sICH). Results Of the randomly assigned 80 patients, the primary endpoint occurred in 52.5% (21/40) of TNK group and 50.0% (20/40) of control group, with no significant difference (unadjusted odds ratio, 1.11; 95% confidence interval 0.46–2.66; <i>P</i>=0.82). More early neurological improvement occurred in TNK group than in control group (11 vs. 3, <i>P</i>=0.03), but no significant differences were found in other secondary endpoints, such as mRS 0–2 at 90 days, shift analysis of mRS at 90 days, and change in National Institutes of Health Stroke Scale score at 24 hours and 7 days. There were no cases of sICH in this trial; however, asymptomatic intracranial hemorrhage occurred in 3 of the 40 patients (7.5%) in the TNK group. Conclusion This phase 2, randomized, multicenter study suggests that intravenous TNK within 4.5–24 hours of onset may be safe and feasible in AIS patients with a DWI-FLAIR mismatch.