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RISS 인기검색어
- 검색키워드
- 저자 : Yutao Yan (검색결과 5 건)
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Increase in Hypotonic Stress-Induced Endocytic Activity in Macrophages via ClC-3
Yan, Yutao,Ding, Yu,Ming, Bingxia,Du, Wenjiao,Kong, Xiaoling,Tian, Li,Zheng, Fang,Fang, Min,Tan, Zheng,Gong, Feili Korean Society for Molecular and Cellular Biology 2014 Molecules and cells Vol.37 No.5
Extracellular hypotonic stress can affect cellular function. Whether and how hypotonicity affects immune cell function remains to be elucidated. Macrophages are immune cells that play key roles in adaptive and innate in immune reactions. The purpose of this study was to investigate the role and underlying mechanism of hypotonic stress in the function of bone marrow-derived macrophages (BMDMs). Hypotonic stress increased endocytic activity in BMDMs, but there was no significant change in the expression of CD80, CD86, and MHC class II molecules, nor in the secretion of TNF-${\alpha}$ or IL-10 by BMDMs. Furthermore, the enhanced endocytic activity of BMDMs triggered by hypotonic stress was significantly inhibited by chloride channel-3 (ClC-3) siRNA. Our findings suggest that hypotonic stress can induce endocytosis in BMDMs and that ClC-3 plays a central role in the endocytic process.
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Numerical study of coupling damage between contact fatigue and sliding wear
Yutao Yan,Xin Wu,Cheng Jiang 대한기계학회 2022 JOURNAL OF MECHANICAL SCIENCE AND TECHNOLOGY Vol.36 No.7
For mechanical elements subjected to the coupling damage from both contact fatigue and sliding wear, the traditional single failure criterion has significant limitations for the designs requiring high reliability and high precision. Therefore, based on the combination of analytical approach and numerical method, a novel coupling analysis method of contact fatigue damage and sliding wear damage for a typical linear contact is proposed in this paper. In this method, a reasonable model for damage correction coefficient, taking into the load, the temperature and the friction coefficient, is developed for the purpose of determining the operating stress of coupling conditions. The model of contact fatigue damage contribution rate and sliding wear damage contribution rate are proposed. Furthermore, a coupling model for contact fatigue damage and sliding wear damage is developed, and the applicable damage criterion is determined. The rationality and practicability of the coupling analysis method proposed are verified by two examples.
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Investigation on coupling analysis method of bending fatigue damage and sliding wear damage
Yutao Yan,Zhao Zhang,Kai Feng 대한기계학회 2023 JOURNAL OF MECHANICAL SCIENCE AND TECHNOLOGY Vol.37 No.9
Bending fatigue and sliding wear are two main damage forms of mechanical components failure and are widely present in mechanical products. The two damages are interrelated and complicated in active system. Therefore, it is incomplete to use any single damage criterion for the analysis and design. This paper proposes a coupling analysis method of bending fatigue damage and sliding wear damage in typical linear contact. A model of the coupling damage is established and the applicable failure criterion based on damage contribution rate is determined. The rationality and practicability of the coupling analysis method proposed are verified by the example and experiment. It is shown that the equivalent stress increases with increasing of wear depth and normal load, the life of coupling damage reduces, and the typical inflection points appear in the coupling damage life curve, which indicates the failure mode changed.
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Increase in Hypotonic Stress-Induced Endocytic Activity in Macrophages via ClC-3
Yutao Yan,Yu Ding,Bingxia Ming,Wenjiao Du,Xiaoling Kong,Li Tian,Fang Zheng,Min Fang,Zheng Tan,Feili Gong 한국분자세포생물학회 2014 Molecules and cells Vol.37 No.5
Extracellular hypotonic stress can affect cellular function. Whether and how hypotonicity affects immune cell function remains to be elucidated. Macrophages are immune cells that play key roles in adaptive and innate in immune reactions. The purpose of this study was to investigate the role and underlying mechanism of hypotonic stress in the function of bone marrow-derived macrophages (BMDMs). Hypotonic stress increased endocytic activity in BMDMs, but there was no significant change in the expression of CD80, CD86, and MHC class II molecules, nor in the secretion of TNF- or IL-10 by BMDMs. Furthermore, the enhanced endocytic activity of BMDMs triggered by hypotonic stress was significantly inhibited by chloride channel-3 (ClC-3) siRNA. Our findings suggest that hypotonic stress can induce endocytosis in BMDMs and that ClC-3 plays a central role in the endocytic process.
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Yibo Zhang,Zhili Sun,Yutao Yan,Zhenliang Yu,Jian Wang 국제구조공학회 2020 Structural Engineering and Mechanics, An Int'l Jou Vol.75 No.6
Reliability analysis techniques combining with various surrogate models have attracted increasing attention because of their accuracy and great efficiency. However, they primarily focus on the structures with continuous response, while very rare researches on the reliability analysis for structures with discontinuous response are carried out. Furthermore, existing adaptive reliability analysis methods based on importance sampling (IS) still have some intractable defects when dealing with small failure probability, and there is no related research on reliability analysis for structures involving discontinuous response and small failure probability. Therefore, this paper proposes a novel reliability analysis method called AGPC-IS for such structures, which combines adaptive Gaussian process classification (GPC) and adaptive-kernel-density-estimation-based IS. In AGPC-IS, an efficient adaptive strategy for design of experiments (DoE), taking into consideration the classification uncertainty, the sampling uniformity and the regional classification accuracy improvement, is developed with the purpose of improving the accuracy of Gaussian process classifier. The adaptive kernel density estimation is introduced for constructing the quasi-optimal density function of IS. In addition, a novel and more precise stopping criterion is also developed from the perspective of the stability of failure probability estimation. The efficiency, superiority and practicability of AGPC-IS are verified by three examples.
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