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- 저자 : YunRu Liu (검색결과 2 건)
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YunRu Liu,TsungMing Hu,TsuoHung Lan,HsienJane Chiu,YungHan Chang,ShuoFei Chen,YenHsin Yu,ChengChung Chen,ElWui Loh 대한신경정신의학회 2004 PSYCHIATRY INVESTIGATION Vol.1 No.2
Objective-Metabolic abnormalities, e.g., diabetes, are common among schizophrenia patients. Peroxisome proliferator activated receptor-γ (PPAR-γ) regulates glucose/lipid metabolisms, and schizophrenia like syndrome may be induced by actions involving retinoid X receptor-α/PPAR-γ heterodimers. We examined a possible role of the PPAR-γ gene in metabolic traits and psychosis profile in schizophrenia patients exposed to antipsychotics. Methods-Single nucleotide polymorphisms (SNPs) of the PPAR-γ gene and a serial of metabolic traits were determined in 394 schizophrenia patients, among which 372 were rated with Positive and Negative Syndrome Scale (PANSS). Results-SNP-10, -12, -18, -19, -20 and -26 were associated with glycated hemoglobin (HbA1c) whereas SNP-18, -19, -20 and -26 were associated with fasting plasma glucose (FPG). While SNP-23 was associated with triglycerides, no associations were identified between the other SNPs and lipids. Further haplotype analysis demonstrated an association between the PPAR-γ gene and psychosis profile. Conclusion-Our study suggests a role of the PPAR-γ gene in altered glucose levels and psychosis profile in schizophrenia patients exposed to antipsychotics. Although the Pro12Ala at exon B has been concerned an essential variant in the development of obesity, the lack of association of the variant with metabolic traits in this study should not be treated as impossibility or a proof of error because other factors, e.g., genes regulated by PPAR-γ, may have complicated the development of metabolic abnormalities. Whether the PPAR-γ gene modifies the risk of metabolic abnormalities or psychosis, or causes metabolic abnormalities that lead to psychosis, remains to be examined.
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Shuxia Li,Yunru An,Shaya Hailati,Jing Zhang,Yuman Cao,Yushi Liu,Jincai Geng,Tianming Hu,Peizhi Yang 한국식물학회 2019 Journal of Plant Biology Vol.62 No.5
Cytokinin oxidase/dehydrogenase (CKXs) areinvolved in various physiological processes, includingcytokinins (CKs) catabolism, root system architecture andresponse to abiotic stresses in plants. Alfalfa (Medicagosativa) is a widely cultivated forage which is frequentlythreatened by high salinity, and the potential role of CKXs inalleviating the salt stress in alfalfa lacked attention. In thisstudy, we isolated a CKX gene from alfalfa, MsCKX(MK177192), and identified its biological functions byoverexpressing it in Arabidopsis. MsCKX shares high sequenceidentity with CKX from other legume plants, especiallyMedicago truncatula (98%). MsCKX was clearly tissuespecific,and it was mainly expressed in roots. In addition,the expression of MsCKX increased under salt stress andabscisic acid (ABA) treatment. Overexpression of MsCKXgene increased the activity of CKX, which led to an enlargedroot system in transgenic Arabidopsis plants. Overexpressionof MsCKX gene enhanced salt tolerance of transgenic plantsby maintaining a higher K+/Na+ ratio, enhancing the activities ofantioxidant enzymes to scavenge ROS and increasing theexpression levels of stress-related genes (P5CS1, DREB2,ion transporters and H+ pumps). Taken together, these resultsshed light on the roles of MsCKX involved in salt toleranceand may have applications in salt-resistant breeding ofalfalfa.
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