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Ginsenoside compound K inhibits nuclear factor-kappa B by targeting Annexin A2
Yushi Wang,Hongyan Zhu,He Liu,Yang Li,Bing Zhao,Ying-Hua Jin 고려인삼학회 2019 Journal of Ginseng Research Vol.43 No.3
Background: Ginsenoside compound K(C-K), a major metabolite of ginsenoside, exhibits anticancer activityin various cancer cells and animal models. A cell signaling study has shown that C-K inhibitednuclear factor-kappa B (NF-kB) pathway in human astroglial cells and liver cancer cells. However, themolecular targets of C-K and the initiating events were not elucidated. Methods: Interaction between C-K and Annexin A2 was determined by molecular docking and thermalshift assay. HepG2 cells were treated with C-K, followed by a luciferase reporter assay for NF-lB,immunofluorescence imaging for the subcellular localization of Annexin A2 and NF-lB p50 subunit,coimmunoprecipitation of Annexin A2 and NF-lB p50 subunit, and both cell viability assay and plateclone formation assay to determine the cell viability. Results: Both molecular docking and thermal shift assay positively confirmed the interaction betweenAnnexin A2 and C-K. This interaction prevented the interaction between Annexin A2 and NF-lB p50subunit and their nuclear colocalization, which attenuated the activation of NF-lB and the expression ofits downstream genes, followed by the activation of caspase 9 and 3. In addition, the overexpression ofAnnexin A2-K320A, a C-K binding-deficient mutant of Annexin A2, rendered cells to resist C-K treatment,indicating that C-K exerts its cytotoxic activity mainly by targeting Annexin A2. Conclusion: This study for the first time revealed a cellular target of C-K and the molecular mechanismfor its anticancer activity.
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Daisuke Terazono,Jia Liu,Yushi Miura,Toshifumi Ise 전력전자학회 2019 ICPE(ISPE)논문집 Vol.2019 No.5
The increasing penetration rate of inverterinterfaced distributed generators (DGs) will lead to the inertia decrease of the grid. To solve it, virtual synchronous generator (VSG) control, which enables inverter-interfaced DGs to have inertia like synchronous generators (SGs), has been proposed. However, VSG control requires extra energy storage to emulate kinetic energy fluctuation in rotating mass of SGs. In this study, kinetic energy of motors existing in the grid as loads is temporarily utilized to absorb disturbance in the grid so that the cost of energy storage is minimized. Furthermore, as a large portion of loads in the grid consists of motors, large inertia support can be expected. To achieve it, VSG control is applied to grid side converter of back-toback ac-dc-ac converter in a motor drive system, and coordinated control between VSG control and motor speed control is proposed. The effectiveness of suppression of grid frequency fluctuation by the proposed control system is shown through simulation results.
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Rapid Microwave Irradiation Synthesis and Photoelectrochemical Performance of Cu3BiS3 nanoparticles
Wei Wang,Guowei Zhi,Liu Liu,Yujie Fei,QinYang Sheng,Yushi Shi,Hanyu Yao,Hongqiang Qian 대한금속·재료학회 2022 ELECTRONIC MATERIALS LETTERS Vol.18 No.6
A photocatalytic material with high performance and low cost plays a decisive role in the industrialization of photocatalytichydrogen evolution. In this work, Cu3BiS3 nanoparticles were successfully synthesized by the microwave irradiationmethod, and the formation mechanism of Cu3BiS3 was studied. The Cu3BiS3 was a nanorod structure with 122 nm diameterand 41 nm length. The band gap was 1.31 eV and the EVB was located at 0.15 eV from the Mott-Schottky analysis. The Cu3BiS3 electrode exhibited an excellent HER performance with an onset potential of 870 mV, a Tafel slope of 251.07mV/dec. And the charge transfer resistance (Rct) of Cu3BiS3 electrode was 7.2 Ω. The electrode also revealed the goodphotoelectric response ability. The electrode also revealed the good photoelectric response ability and good stability bytime course of the photocurrents. This work provided a fast, low-cost method to prepare the Cu3BiS3 for photocatalysiswater splitting.
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Betulin induces reactive oxygen species-dependent apoptosis in human gastric cancer SGC7901 cells
Yang Li,Xiaokang Liu,Dan Jiang,Yingjia Lin,Yushi Wang,Qing Li,Linlin Liu,Ying-Hua Jin 대한약학회 2016 Archives of Pharmacal Research Vol.39 No.9
Betulin, an abundant natural compound, significantly inhibited the cell viability of advanced human gastric cancer SGC7901 cells. Mechanism study demonstrated that betulin induced apoptosis through mitochondrial Bax and Bak accumulation-mediated intrinsic apoptosis pathway. Downregulation of the anti-apoptosis proteins Bcl-2 and XIAP was involved during betulin-induced cell apoptosis. Reactive oxygen species (ROS) was generated in cells after betulin treatment in a time- and dose-dependent manner. Addition of antioxidant N-acetyl-L-cysteine (NAC) significantly attenuated betulin-induced ROS generation as well as Bcl-2 and XIAP downregulation. The mitochondrial accumulation of Bax and Bak, as well as caspase activity, was also remarkably inhibited by NAC treatment, indicating that ROS are important signaling intermediates that lead to betulin-induced apoptosis by modulating multiple apoptosis-regulating proteins in SGC7901 cells.
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Shuxia Li,Yunru An,Shaya Hailati,Jing Zhang,Yuman Cao,Yushi Liu,Jincai Geng,Tianming Hu,Peizhi Yang 한국식물학회 2019 Journal of Plant Biology Vol.62 No.5
Cytokinin oxidase/dehydrogenase (CKXs) areinvolved in various physiological processes, includingcytokinins (CKs) catabolism, root system architecture andresponse to abiotic stresses in plants. Alfalfa (Medicagosativa) is a widely cultivated forage which is frequentlythreatened by high salinity, and the potential role of CKXs inalleviating the salt stress in alfalfa lacked attention. In thisstudy, we isolated a CKX gene from alfalfa, MsCKX(MK177192), and identified its biological functions byoverexpressing it in Arabidopsis. MsCKX shares high sequenceidentity with CKX from other legume plants, especiallyMedicago truncatula (98%). MsCKX was clearly tissuespecific,and it was mainly expressed in roots. In addition,the expression of MsCKX increased under salt stress andabscisic acid (ABA) treatment. Overexpression of MsCKXgene increased the activity of CKX, which led to an enlargedroot system in transgenic Arabidopsis plants. Overexpressionof MsCKX gene enhanced salt tolerance of transgenic plantsby maintaining a higher K+/Na+ ratio, enhancing the activities ofantioxidant enzymes to scavenge ROS and increasing theexpression levels of stress-related genes (P5CS1, DREB2,ion transporters and H+ pumps). Taken together, these resultsshed light on the roles of MsCKX involved in salt toleranceand may have applications in salt-resistant breeding ofalfalfa.
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