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        • KCI등재후보SCOPUS

          Diagnostic Importance of 3D CT Images in Klippel-Feil Syndrome with Multiple Skeletal Anomalies: A Case Report

          Murvet,Yuksel,Hamza,Karabiber,K.,Zafer,Yuksel,Gonul,Parmaksiz 대한영상의학회 2005 Korean Journal of Radiology Vol.6 No.4

          We present here the case of a 12-year-old boy who had Klippel-Feil syndrome with renal, cardiac and multiple skeletal anomalies, and we show the relevent three-dimensional computed tomography images. Our patient had a triple renal pelvis, mitral valve prolapsus, multiple cervical vertebrae fusions, cervical ribs, hypoplasia of the right thumb, spina bifida of L5, lumbalization at the right side of S1 and a sacral curved defect. In this study, we discuss the atypical clinical features and the diagnostic value of three-dimensional CT for evaluating the skeletal anomalies of the Klippel-Feil syndrome cases.

        • Association of ABO Blood Group and Risk of Lung Cancer in a Multicenter Study in Turkey

          Urun,,Yuksel,Utkan,,Gungor,Cangir,,Ayten,Kayi,Oksuzoglu,,Omur,Berna,Ozdemir,,Nuriye,Oztuna,,Derya,Gokmen,Kocaman,,Gokhan,Coskun,,Hasan,Senol,Kaplan,,Muhammet,Ali,Yuksel,,Cabir,Demirkazik,,Ahmet,Icli, Asian Pacific Organization for Cancer Prevention 2013 Asian Pacific journal of cancer prevention Vol.14 No.5

          Background: The ABO blood groups and Rh factor may affect the risk of lung cancer. Materials and Methods: We analyzed 2,044 lung cancer patients with serologically confirmed ABO/Rh blood group. A group of 3,022,883 healthy blood donors of Turkish Red Crescent was identified as a control group. We compared the distributions of ABO/Rh blood group between them. Results: The median age was 62 years (range: 17-90). There was a clear male predominance (84% vs. 16%). Overall distributions of ABO blood groups were significantly different between patients and controls (p=0.01). There were also significant differences between patients and controls with respect to Rh positive vs. Rh negative (p=0.04) and O vs. non-O (p=0.002). There were no statistically significant differences of blood groups with respect to sex, age, or histology. Conclusions: In the study population, ABO blood types were associated with the lung cancer. Having non-O blood type and Rh-negative feature increased the risk of lung cancer. However, further prospective studies are necessary to define the mechanisms by which ABO blood type may influence the lung cancer risk.

        • KCI등재SCOPUS

          Investigation of the Effect on the Physical and Mechanical Properties of the Dosage of Additive in Self-consolidating Concrete

          Yuksel,Esen,Eyyup,Orhan 대한토목학회 2016 KSCE JOURNAL OF CIVIL ENGINEERING Vol.20 No.7

          The objective of this study was to investigate the effect of superplasticizer and mineral admixture contents on the properties of Self-Consolidating Concrete (SCC). Silica fume was used as a mineral admixture and polycarboxylate based third generation superplasticizer was used as a chemical admixture. In order to determine the optimum admixture dosages; trial mixes were prepared with varying admixture dosages. Nine concrete mixtures with different admixture dosages were prepared from trial mixes. Hardened concrete properties and self-compactability criteria of these series were determined and test results were compared between these SCC mixtures. It was observed that 10S1.3A (10% Silica Fume, 1.3% Superplasticizer) and 10S1.5A (10% Silica Fume, 1.5% Superplasticizer) mixtures show the best performance with regard to fresh and hardened concrete properties.

        • KCI등재SCOPUS

          Assessment of non-prismatic beams having symmetrical parabolic haunches with constant haunch length ratio of 0.5

          Yuksel,,S.,Bahadir Techno-Press 2012 Structural Engineering and Mechanics, An Int'l Jou Vol.42 No.6

          Single span historic bridges often contain non-prismatic members identified with a varying depth along their span lengths. Commonly, the symmetric parabolic height variations having the constant haunch length ratio of 0.5 have been selected to lower the stresses at the high bending moment points and to maintain the deflections within the acceptable limits. Due to their non-prismatic geometrical configuration, their assessment, particularly the computation of fixed-end horizontal forces (FEFs) and fixed-end moments (FEMs) becomes a complex problem. Therefore, this study aimed to investigate the behavior of non-prismatic beams with symmetrical parabolic haunches (NBSPH) having the constant haunch length ratio of 0.5 using finite element analyses (FEA). FEFs and FEMs due to vertical loadings as well as the stiffness coefficients and the carry-over factors were computed through a comprehensive parametric study using FEA. It was demonstrated that the conventional methods using frame elements can lead to significant errors, and the deviations can reach to unacceptable levels for these types of structures. Despite the robustness of FEA, the generation of FEFs and FEMs using the nodal outputs of the detailed finite element mesh still remains an intricate task. Therefore, this study advances to propose effective formulas and dimensionless estimation coefficients to predict the FEFs, FEMs, stiffness coefficients and carry-over factors with reasonable accuracy for the analysis and re-evaluation of the NBSPH. Using the proposed approach, the fixed-end reactions due to vertical loads, and also the stiffness coefficients and the carry-over factors of the NBSPH can be determined without necessitating the detailed FEA.

        • KCI등재SCIE

          The Effect of Dexpanthenol on Ototoxicity Induced by Cisplatin

          Yuksel,Toplu,Emrah,Sapmaz,Hakan,Parlakpinar,Mehmet,Kelles,M.,Tayyar,Kalcioglu,Kevser,Tanbek,Ahmet,Kizilay 대한이비인후과학회 2016 Clinical and Experimental Otorhinolaryngology Vol.9 No.1

          Objectives. This study was aimed to investigate the protective effects of dexpanthenol (Dxp) on against cisplatin-induced ototoxicity. Methods. To examine this effect, distortion product otoacoustic emissions (DPOAEs) measurements and serum levels of oxidative and antioxidant status (including malondialdehyde, superoxide dismutase, catalase, glutathione, glutathione peroxidase, total oxidant status, total antioxidant status, and oxidative stress index) were evaluated. Thirty-two adult female Wistar albino rats were randomly divided into 4 equal groups; control (K), cisplatin (C), cisplatin plus Dxp (CD), and Dxp (D). In all groups DPOAEs measurements, between 996 and 10,078 Hz as DPOAEs and input/output functions, were performed on days 0, 1th, 5th, and 12th. Prior to death, the last DPOAEs measurements and blood samples were taken. Results. In the C group, statistically significant differences were detected at all frequencies between 0 and 5 days and 0 and 12 days measurements (P<0.05). Serum level of oxidant and antioxidant status were detected statistically significantly changed in this group versus K group (P<0.05). Contrary to the C group, in the CD group hearing ability was seen largely preserved at many frequencies and serum levels of all biochemical parameters were shifted toward normal values, similar to the K group. No significant differences were detected in the either D or K group's measurements. Conclusion. According to these results, Dxp may prevent cisplatin-induced ototoxicity.

        • Predictive Value of the Platelet-To-Lymphocyte Ratio in Diagnosis of Prostate Cancer

          Yuksel,,Ozgur,Haki,Urkmez,,Ahmet,Akan,,Serkan,Yldirim,,Caglar,Verit,,Ayhan Asian Pacific Organization for Cancer Prevention 2015 Asian Pacific journal of cancer prevention Vol.16 No.15

          Purpose: To predict prostatic carcinoma using a logistic regression model on prebiopsy peripheral blood samples. Materials and Methods: Data of a total of 873 patients who consulted Urology Outpatient Clinics of Fatih Sultan Mehmet Training and Research Hospital between February 2008 and April 2014 scheduled for prostate biopsy were screened retrospectively. PSA levels, prostate volumes, prebiopsy whole blood cell counts, neutrophil and platelet counts, neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), biopsy results and Gleason scores in patients who had established diagnosis of prostate cancer (PCa) were evaluated. Results: This study was performed on a total of 873 cases, with an age range 48-76 years, divided into three groups as for biopsy results. with diagnoses of benign prostatic hyperplasia (BPH) (n=304, 34.8 %), PCa (n=265, 30.4 %) and histological prostatitis (n=304; 34.8 %). Intra- and intergroup comparative evaluations were performed. White blood cell and neutrophil counts in the histological prostatitis group were significantly higher than those of the BPH and PCa groups (p=0.001; p=0.004; p<0.01). A statistically significant intergroup difference was found for PLR (p=0.041; p<0.05) but not lymphocyte count (p>0.05). According to pairwise comparisons, PLR were significantly higher in the PCa group relative to BPH group (p=0.018, p<0.05, respectively). Though not statistically significant, higher PLR in cases with PCa in comparison with the prostatitis group was remarkable (p=0.067, and p>0.05, respectively). Conclusions: Meta-analyses showed that in patients with PSA levels over 4 ng/ml, positive predictive value of PSA is only 25 percent. Therefore, novel markers which can both detect clinically significant prostate cancer, and also prevent unnecessary biopsies are needed. Relevant to this issue in addition to PSA density, velocity, and PCA3, various markers have been analyzed. In the present study, PLR were found to be the additional predictor of prostatic carcinoma.

        • KCI등재SCOPUS

          Effect of High Temperature in Concrete for Different Mineral Additives and Rates

          Yuksel,Esen,Alper,Kurt 대한토목학회 2018 KSCE JOURNAL OF CIVIL ENGINEERING Vol.22 No.4

          In this study, the change of the effect of high temperature in concrete by the types of mineral additives was examinedexperimentally. For this purpose, CEM I 42,5 R cement was used together with different minerals such as Barite, Diatomite, Silicafume, F class Fly ash that are added in a substituted manner at the rates of 10%, 20%, 30% and 40% by volume. Dry unit weights,underwater weights and water saturated weights of these concrete samples with mineral additives with 28-day strength werefound. Ultrasonic Pulse Velocity (UPV) measurements of the concrete samples, the water absorption percentages by weight ofwhich were determined, were performed. The samples which were then exposed to high temperatures such as 200, 400, 600 and800°C were left for cooling at room temperature, and then, their compressive strength was measured. While the highest waterabsorption rates were in Diatomite reinforced concrete, the highest compressive strengths were obtained in Silica fume reinforcedconcrete.

        • Analysis of Radiofrequency Ablation of Small Renal Tumors in Patients at High Anesthetic and Surgical Risk: Urologist Experience with Follow-up Results in the Initial Six Months

          Yuksel,,Mehmet,Bilgehan,Karakose,,Ayhan,Gumus,,Bilal,Tarhan,,Serdar,Atesci,,Yusuf,Ziya,Akan,,Zafer Asian Pacific Organization for Cancer Prevention 2013 Asian Pacific journal of cancer prevention Vol.14 No.11

          Background: To evaluate the results of various types of radiofrequency ablation (RFA) treatment of renal tumors in patients with excessive anesthetic and surgical risk. Materials and Methods: Data for RFA performed in in high risk patients were retrospectively evaluated. Other RFA applications in patients with no anesthetic and/or surgical risk were excluded. RFA was by ultrasound or CT guided percutaneous (USG/CT-PRFA) and retroperitoneally or transperitoneally laparoscopic (R/T-LRFA) techniques under general or local anethesia. Follow-up data of enhanced CT or MRI after 1, 3 and 6 months were analysed for twelve RFA applications. Results: The RFA applications included 4 (40%) left-sided, 5 (50%) right-sided and 1 (10%) bilaterally RFA (simultaneously 1 right and 2 left). The localizations of tumors were 2 (16.6%) upper, 5 (41.6%) mid and 5 (41.6%) lower pole. The RFA applications included 9 (75%) USG-PRFA, 1 (8.3%) CT-PRFA, 1 (8.3%) T-LRFA and 1 (8.3%) R-LRFA. The mean age was $65.3{\pm}8.5$ (52-76) years. The mean tumor size was $29.6{\pm}6.08$ (15-40) mm. No complications related to the RFA were encountered in any of the cases. Failure (residual tumour) was determined in 8.3% (1/12) of USG-RFA application. The success rate was thus 91.7% (11/12). Other 1st, 3rd and 6th months follow-up data revealed no residua and recurrence. Conclusions: RFA application appears to be safe as a less invasive and effective treatment modality in selected cases of small renal tumors in individuals with excessive anesthetic and also surgical risk.

        • SCIESCOPUSKCI등재후보

          Quasi-static cyclic displacement pattern for seismic evaluation of reinforced concrete columns

          Yuksel,,E.,Surmeli,,M. Techno-Press 2011 Structural Engineering and Mechanics, An Int'l Jou Vol.37 No.3

          Although earthquakes generate random cyclic lateral loading on structures, a quasi-static cyclic loading pattern with gradually increasing amplitude has been commonly used in the laboratory tests because of its relatively low cost and simplicity compared with pseudo-dynamic and shake table tests. The number, amplitudes and sequence of cycles must be chosen appropriately as important parameters of a quasi-static cyclic loading pattern in order to account for cumulative damage matter. This paper aims to reach a new cyclic displacement pattern to be used in quasi-static tests of well-confined, flexure-dominated reinforced concrete (RC) columns. The main parameters of the study are sectional dimensions, percentage of longitudinal reinforcement, axial force intensity and earthquake types, namely, far-fault and near-fault.

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