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- 저자 : Yuan-Huan Ma (검색결과 5 건)
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Multimodal Repair of Spinal Cord Injury With Mesenchymal Stem Cells
Yuan-huan Ma,Qing-yue Liang,Ying Ding,한인보,Xiang Zeng 대한척추신경외과학회 2022 Neurospine Vol.19 No.3
Spinal cord injury (SCI) is a result of a devastating injury to the central nervous system. Currently, there is no effective treatment available for these patients. The possible use of mesenchymal stem cell (MSC)-based treatment for SCI has been the focus of extensive investigations and is increasingly moving from the bench to bedside. Both experimental observations and clinical studies have shown the safety and efficacy of MSCs in managing SCI. However, the exact mechanism by which MSCs contribute to the repair of the injured spinal cord remains to be elucidated. In this review, we aim to summarize current research findings about the role of MSCs in improving complex pathology after SCI. MSCs exert a multimodal repair mechanism targeting multiple events in the secondary injury cascade. Our recent results showing the perineurium-like differentiation of surviving MSCs in the injured spinal cord may further the understanding of the fate of transplanted MSCs. These findings provide fundamental support for the clinical use of MSCs in SCI patients. Under experimental conditions, combining novel physical, chemical, and biological approaches led to significant improvements in the therapeutic efficacy of MSCs. These findings hold promise for the future of cell-based clinical treatment of SCI.
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Zhanwei Yuan,Huan Liu,Zhe Ma,Xinkai Ma,Kai Wang,Xuemin Zhang 대한금속·재료학회 2023 METALS AND MATERIALS International Vol.29 No.5
In this paper, CoCrFeNiMo0.2particles reinforced titanium matrix composites were prepared by hot pressing sintering in thevacuum, and the volume fraction of CoCrFeNiMo0.2particles was 7%. The microstructure of the composites was analyzed byX-ray diffraction, scanning electron microscope and electron probe, and the micro-mechanical properties of the compositeswere studied by nano indentation technology. Based on the combination of experimental research and numerical simulation,the deformation process and damage behavior of the composites were studied. The tensile strength of the compositeswas 689 MPa, and the strain at break was 12.2%. The damage behavior and stress–strain curve of the composites in thein-situ tensile process were compared with the simulation process to verify the accuracy of the modeling results. Throughthe analysis of the simulation results, it is found that the particles bear a larger load than the matrix during the deformationprocess. When the composites reach the peak stress, the average stress on the particles is about 580 MPa, the average stresson the interface is about 620 MPa, and the average stress on the matrix is about 446 MPa.
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Lisha Wang,Jinghua Jiang,Ting Yuan,Qiuyuan Xie,Huan Liu,Aibin Ma 대한금속·재료학회 2020 METALS AND MATERIALS International Vol.26 No.5
Mg alloys containing long period stacking ordered (LPSO) structures possess excellent mechanical properties and corrosionresistance, exhibiting great application potential in biodegradable implants. The corrosion process of different LPSOphases in the Mg alloys need to be furtherly clarified in different solution environments. In this paper, we mainly reviewedthe influencing factors on the corrosion behavior of LPSO-containing Mg alloys, including the alloying elements, processingtechnologies, and the types, volume fractions and distributions of LPSO phases. Recent researches are well summarized withan emphasis on their corrosion mechanism. Special attention is given to the key issues for LPSO-containing Mg alloys asbiomedical implants, with their biodegradation behavior comprehensively discussed. The motivation is to provide theoreticalsupport for the possible application of LPSO-containing Mg alloys in the biomedical field.
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Xingru Xiao,Qingwen Deng,Xiang Zeng,Bi-Qin Lai,Yuan-Huan Ma,Ge Li,Yuan-Shan Zeng,Ying Ding 대한척추신경외과학회 2022 Neurospine Vol.19 No.3
Objective: This study aimed to identify differentially expressed genes (DEGs) by transcriptome analysis to elucidate a potential mechanism by which governor vessel electroacupuncture (GV-EA) promotes neuronal survival, axonal regeneration, and functional recovery after complete transection spinal cord injury (SCI). Methods: Sham, control, or GV-EA group adult female Sprague Dawley rats underwent a complete transection SCI protocol. SCI area RNA-seq investigated the DEGs of coding and noncoding RNAs 7 days post-SCI. Gene ontology (GO) and kyoto encyclopedia of genes and genomes (KEGG) enrichment analyses were used to classify DEGs functions, to explain a possible molecular mechanism. Immunofluorescence and BBB (Basso, Beattie, and Bresnahan) score were used to verify a GV-EA treatment effect following SCI. Results: GV-EA treatment could regulate the expression of 173 mRNA, 260 lncRNA, and 153 circRNA genes among these DEGs resulted by SCI. GO enrichment analysis showed that the DEGs were most enriched in membrane, actin binding, and regulation of Toll-like receptor signaling pathway. KEGG pathway analysis showed enriched pathways (e.g. , Tolllike receptors, MAPK, Hippo signaling). According to the ceRNA network, miR-144-3p played a regulatory role by interacting with lncRNA and circRNA. GV-EA also promoted the injured spinal cord neuron survival, axonal regeneration, and functional improvement of hind limb locomotion. Conclusion: Results of our RNA-seq suggest that post-SCI GV-EA may regulate characteristic changes in transcriptome gene expression, potential critical genes, and signaling pathways, providing clear directions for further investigation into the mechanism of GV-EA in subacute SCI treatment. Moreover, we found that GV-EA promotes neuronal survival, nerve fiber extension, and motor function recovery in subacute SCI.
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