외상성 뇌손상 환자의 삶의 질에 대한 임상적 고찰

노승호,천영훈 圓光大學校 醫科大學 神經精神科學敎室 1998 圓光精神醫學 Vol.14 No.1

목적 : TBI 후유증의 증상이 안정된 이후 환자들의 삶의 질은 어느 정도의 수준인지, 그리고 삶의 질 수준이 높은 집단과 낮은 집단은 인구 통계적 변인, 정신사회적 기능 및 신경행동 증상들의 측면에서 어떤 차이가 있는지를 알아보고자 하였다. 방법 : TBI 환자 46명 중 삶의 목적 수준이 높은 집단과 낮은 집단을 각각 15명씩 선정하여 대상군으로 하였고, TBI 환자의 친지들 중 연령과 성 및 교육수준이 비슷한 사람들을 선정하여 대조군으로 하였다. QOLI, SIP, PIL, HISC, NRS를 사용하여 삶의 질, 정신사회적 기능, 삶의 목적, 자각적 및 타각적 신경행동 증상을 평가하여 서로 비교하였다. 결과 : 1)TBI군의 삶의 질은 정상 대조군의 1/3 수준(66.1±23.4 : 6.5±2.5)이었으며, 정신 사회적 기능 및 삶의 목적 수준은 대조군보다 유의하게 낮았고, 자각적 및 타각적 신경행동 증상은 유의하게 심했다(P<.01). 2)TBI군 중 삶의 질 수준이 높은 집단은 낮은 집단에 비해 외상 전과 외상 후 지능이 유의하게 높았다(각각 p<.05, p<.01). 그러나 연령, 성비, 교육수준, 결혼 및 직업상태, 외상의 원인 및 심각도, 외상후 기간에서는 두 군 간에 차이가 없었다. 3)TBI군 중 삶의 질 수준이 높은 집단은 낮은 집단에 비해 정신사회적 기능과 삶의 목적 수준이 유의하게 높았으며, 자각적 및 타각적 증상은 더 적었다(각각p<.01, p<.05, p<.01, P<.05). 4)STBI는 MTBI보다 정신사회적 장해와 자각적 증상이 유의하게 심했다(p<.05, p<.05).그러나 삶의 질 및 목적 수준과 타각적 증상은 두 군간에 차이가 없었다. 결론 : TBI 환자의 삶의 질은 증상이 고정된 이후에도 비장애인보다 현저히 낮은 수준에 머물고 있었으며, 삶의 질 수준이 상대적으로 높은 집단은 낮은 집단에 비해 수상 전, 후의 지능이 높았고, 외상의 심각도가 낮았으며, 정신사회적 기능과 삶의 목적 수준은 더 높았고, 자각적 및 타각적 증상은 더 적었다. This study was designed to investigate the quality of life(QOL) level of the patients with TBI after the symptoms of sequelae was stabilized, and the differences between the patients with higher QOL and those with lower QOL and those with lower QOL in demographic variables, psychosocial functioning, and neurobehavioral symptoms. The subjects were composed of patients with higher QOL(N=15, Group 1) and those with lower QOL(N=15, Group 2), who were assigned according to the level of QOL among 46 patients with TBI, and 30 normal control group. The levels of QOL, psychosocial functioning, purpose in life, and subjective and objective neurobehavioral symptoms were rated by QOLI, SIP, PIL, HISC, and NRS. The results was as follows. 1)In comparing to the normal control group, QOL level of TBI group remained about 1/3 of that of control(66.1±23.4 : 6.5±2.5, respectively). The brain injured patients had significantly lower levels of psychosocial functioning and purpose in life(p<.01), and more severe subjective and objective neurobehavioral symptoms(p<.01). 2)In comparing demographic and clinical variables between Group 1 and 2, pre- and post- injury IQ of Group 1 were significantly higher than those of Group 2(p<.05, p<.01, respectively). But significant differences were not found in other variables(e.g., age, sex, education, marital status, cause and severity of injury, and duration after injury). 3)Group 1 had significantly higher psychosocial function and purpose in life levels, and less subjective and objective symptoms than Group 2(p<.01, p<.05, p<.01, p<.05, respectively). 4)STBI experienced more severe psychosocial impairment and subjective symptoms than MTBI(p<.05, p<.05). However, in QOL and purpose in life level and objective symptoms there were no difference between STBI and MTBI.

제주해협의 해류와 월별 유량변화

노홍길,방익찬,김상현,현경훈,김준택,양영진,홍창수 제주대학교 해양연구소 1997 해양자원연구소연구보고 Vol.21 No.-

Currents are measured in the Straits of Cheju by detecting surface buoy tracks and mooring current meters in 1996-1997. As a result, north-eastward currents are decteted in the Straits of Cheju all the year round, which is weak in spring and strong in summer and fall. Average speeds of 20 cm/s to the east. 7 cm/s to the north and 22 cm/s to the north-east appeared in the surface. Currents are fast in the middle of the strait and slow near Cheju Island. East-west components of the currents are about 3 times faster than the north-south ones. Also. it is shown that surface buoys released within the distance of 6 miles away from Cheju do not drift out of the Straits of Cheju because of tongue-like warm waters appeared in the eastern entrance of the strait. Volume transports calculated by geostrophic calculation are shown to be 0.05-0.2 Sv in winter and 0.4-0.5 Sv in summer.

게임敎材의 構造分析

盧永九 대구교육대학교 1996 論文集 Vol.31 No.-

제조업 근로자의 수면실태에 관한 조사

노정균,류기하,이영수,조영채 大韓産業醫學會 1994 대한직업환경의학회지 Vol.6 No.2

산업체 근로자의 수면실태를 조사하고자 1993년 3월에 한 고무제품 제조업 근로자 479명을 대상으로 수면양상에 대한 설문조사를 실시한 결과는 다음과 같다. 1. 전체 조사대상자의 수면장애 유병율은 32.8%였으며, 수면장애의 유형별로는 취면곤란 11.9%, 수면유지곤란6.1%, 조조각성이 6.9%였다. 2. 연령군별 수면유지곤란은 20대가 가장 낮았고 30대가 가장 높았으며, 취침전 진정제 또는 알코올을 이용한 군의 수면장애가 비사용군에 비해 현저히 높게 나타났다. 3. 직업이나 가정에 대해 만족하는 군일수록 수면장애가 불만족군에 비해 낮았으며, 낮잠을 자는 군, 신체적 통증이 없는 군일수록 적게 나타났다. 4. 수면장애에 대한 회귀분석결과 통계적 유의성을 보인 변수는 낮잠여부, 신체적 통증여부 및 근무기간이었다. This study was conducted to investigate sleep qualitys of manufacturing workers. The data were collected from the 479 manufacturing factory workers who were most 3 shift workers. The results obtained were as follows. The prevalence rate of sleep disorder was 32.8%, rate of difficulty in intiating sleep was 11.9%, that of difficulty in maintaining sleep was 6.1%, and that of early morning awakening was 6.9%. Disorders of difficulty in maintaining sleep was low in the age group of twenties and high in thirties. The group of sedative or alcohol use before sleep induction showed high prevalence rate of sleep disorder. The group of satisfying for job or family had the lower rate of sleep disorder than the unsatisfying group. The rate of sleep disorder were low in the group of day sleeping, no physical pain. The variables such as day sleep, physical pain and job tenure showed statistical significance in the logistic regression of sleep disorder.

Cis-Diaminocyclohexane을 배위자로 하는 백금(Ⅱ)착체의 선택적 세포독성

노영수,정세영,정지창 한국환경독성학회 1998 환경독성보건학회지 Vol.13 No.2

The use of cisplatin is limited by severe side effects such as renal toxicity. Our platinum-base drug discovery is aimed at developing drugs capable of diminishing toxicity and improving antitumor activity. We synthesized new Pt (II) complex analogue [Pt (cis-DACH)(DPPP)]ㆍ2NO₂,(PC) containing cis- l,2-diaminocyclohexane as a carrier ligand and 1, 3-bis(diphenylphosphino) propane as a leaving group. Furthermore, nitrate was added to improved the solubility. In this study, its structure was determined and its antitumor activity against SKOV-3 and NIH-OVCAR-3 human ovarian adenocarcinoma, and in nitro cytotoxicity was determined against primary cultured rabbit kidney proximal tubular and renal cortical cells of human kidney using colorimetric MTT assay. PC demonstrated acceptable antitumor activity against SKOV-3 and NIH-0VCAR-3 human ovarian adenocarcinoma and significant activity as compared with that of cisplatin. The toxicity of PC was found quite less than that of cisplatin using MTT and ³H-thymidine uptake tests in rabbit proximal tubular cells and human kidney cortical cells. PC was used for human cortical tissue in 7 weeks hitoculture by the glucose-consumption tests. We determined that the new platinum drug has lower nephrotoxicity than cisplatin. Based on these results, this novel platinum (Ⅱ) complex compound (PC) represent a valuable lead in the development of a new anticancer chemotherapeutic agent capable of improving antitumor activity and low nephrotoxicity.

초등학생 입학 후 발생한 두통의 유병률과 임상적 특성

노영일,김은영,양은석,문경래,박상기,박영봉 朝鮮大學校 附設 醫學硏究所 2003 The Medical Journal of Chosun University Vol.28 No.2

Purpose : The purpose of the study was to determine prevalence and clinical features of the occurrence of childhood headache after the start of elementary school. Method : The survey was performed by a special questionnaire on 552 children in grade 1 (195 children) and grade 6 (357 children) at the three elementary schools from 1 to 31 August, 2002 in Gwangju city. We have analyzed the prevalence and the clinical features of headache of them. Result: The prevalence of headache in grade 6(49.0%) was statistically higher than grade 1(22.6%). The onset time of headache within 6 months in grade 1 (88.2%) was significantly higher than grade 6 (64.1 %). The frequency of headache is more often in grade 6. As for the timing of occurrence of headache, grade 1 student suffered from it after school (36.4%), grade 6 student suffered from it at school (30.9%). Children who suffered from severe headache can't live in the routine life were grade 1 20.5 % and grade 6 21.1 %, respectively. According to the duration of headache, there were within 1 hour grade 1 90.9%, grade 6 81.8%, respectively. Risk factors of headache were, in grade 1, fatigue (34.0%), stress (25.0%), weather change (18.2%), anxiety (11.4%), and others (11.4%). In grade 6, there were fatigue(44.3%), stress (34.0%), weather change(10.9%), others (5.7%) and anxiety (5.1%). Conclusion : Starting school represents a remarkable life event for children. Starting school results in significantly increasing prevalence of overall headache. 목적 : 입학 전에 비해 입학 후 두통의 증가률을 알아보고, 1학년의 두통의 임상적 특징을 알아보고자 하였다. 방법 : 2002년 8월 1일부터 31일까지 광주시내 3개 초등학교 1학년과 6학년 학생 612명에게 설문지 (두통 에 대한 주요 설문지 내용 :부록)를 배부하여 그 중 작성이 불량한 60명을 제외한 552명 (1학년 195명, 6학년 357명)을 대상으로 두통의 유병률을 알아보았으며, 임상적 특징은 두통이 있는 학생 219명 (1학년 44명, 6학년 175명)을 대상으로 분석하였다. 결과 : 두통의 빈도는 1학년 44명 (22.6%), 6학년 175명 (49.0%)로 6학년에서 의의 있게 높았다(0.001). 두통의 초발 시기가 6개월 이상인 경우 1학년 11.8%, 6학년 35.9%이였으며, 6개월 미만인 경우는 1학년 88.2%, 6학년 64.1%로 입학 전보다 입학 후에 더 높았으며 6개월 미만의 초발 두통이 1학년에서 의의 있게 높았다(p=o. 03). 두통의 발생빈도는 6학년에서 통계학적으로 의의 있게 높았다(P=0. 03). 두통이 가장 자주 발생하는 시기는 1학년에서 학교 수업 후 (36.4%)이었고, 6학년에서는 학교 수업 중(30.9%)이었다. 학교나 일상 생활을 하기 힘들 정도의 두통은 각각 1학년에서 20.5%, 6학년에서 21.1%이었다. 두통의 지속시간은 1시간 이내인 경우가 각각 1학년 90.9%,6학년 81.8%이었다. 두통의 유별인자는 1학년에서 피로, 수면 부족이 34.0%로 가장 많았으며, 스트레스, 기후 변화, 불안, 기타 순이었고, 6학년은 피로 수면 부족 44.3%로 가장 많았으며, 스트레스 34.0%, 기후 변화, 기타, 불안 순이었다.

한국기업의 時間基準 競爭을 위한 工程 慣行의 分析

노부호,박영수 서강대학교 경영학연구원 2003 서강경영논총 Vol.14 No.1

본 연구의 목적은 산업별로 시간기준 생산시스템을 수립하는데 기여하는 공정 관행을 분석하는 것이다. 연구의 결과는 다음과 같다. 첫째, 기계산업은 신속한 납기를 위해 기업 내부적인 동시공학과 설비의 보수유지 활동에 많은 투자가 필요하다. 둘째, 섬유산업은 장치형 산업의 특성 때문에 시간기준 생산시스템을 수립할 때 공정관행은 크게 기여하지 못한다. 단지 pull 생산만이 시간경쟁이 기여하는 것으로 나타났다. 셋째, 전기·전자산업은 유연성 향상을 위한 공정관행 즉 셀생산, 외부적인 동시공학 활동, 준비시간 단축 등을 위해 노력해야 한다. 특히 다른 산업과는 달리 고객의 요구를 제품에 반영하기 위해서 실시되는 외부적인 동시공학 활동을 수행함으로써 시간 경쟁능력을 향상시킬 수 있다. The purpose of this study analyzes the ways to establish time-based manufacturing system is the aspect of practices of process practices by the individual industry. The results of this study are as follows. First, the machine industry needs activities for internal CE and maintenance demand a lot of support for delivery promptly. Second, the textile industry show that process practices no contribute to establishment of time-based manufacturing system. Bur pull production contribute to time competition. Third, the electric Industry and the electronic industry must exert themselves to attain the process practices - cellular manufacturing, external concurrent engineering and reduction of setup time - to improve flexibility. Contrary to the different industries, performing external concurrent engineering to reflect customers' demands in products ran raise the ability for time competition.

PECVD로 제작한 수소화된 비정질 탄소(a-C:H) 박막의 화학결합 구조에 관한 연구

노지연,이석호,오동선,박혁렬,김영산 木浦大學校基礎科學硏究所 1997 基礎科學硏究誌 Vol.15 No.-

Hydrogenated amorphous carbon(a-C:H) films were prepared by PECVD(Plasma enhanced-chemical vapor deposition) method. The films were characterized using various spectroscopic measurements such as Raman scattering, FTIR(Fourier transform infrared) absorption spectroscopy. FRIR absorption reflects only the optically active hydrogen in the a-C:H and, using it together with Raman spectroscopy. The spectral analysis indicated that changes in Raman spectroscopy intensity occurring with increasing substrate temperature 50℃~300℃ were determined to be caused by changes in optically resonant components in the films. Furthermore, a significant correlation was the two crystalline forms of carbon-graphite and -diamond consist of sp² and sp³ bonds, respectively. Significant changes in chemical bonding(sp²/sp³) and micro-structure of hydrogenated amorphous carbon thin films occur as the substrate temperature varies from 50 to 300℃ during.

천도교 농민운동의 성과 : 이성환 주도기 조선농민사의 활동을 중심으로

盧榮澤 대구효성가톨릭대학교 1993 연구논문집 Vol.47 No.1

Dibenzotetraazapentalene들의 염기도와 protonation의 위치

노영쇠 全北大學校 基礎科學硏究所 1981 基礎科學 Vol.4 No.1

Dibenzo-1, 3a, 6, 6a-tetraazapentalene(DBTA-1) and dibenzo-1, 3a, 4, 6a-tetraazape-ntalene(DBTA-2) were prepared by known method. The mechanism through which 1-NPB and 2-NPB are formed as the intermediates in the synthetic route is discussed, and their derivatives such as 3-chlorodibenzo-1, 3a, 6, 6a-tetraazapentalene was also synthesized. With the pK values of dibenzotetraazapentalene derivatives measured by UV-spectrophotometer, their degrees of delocalization are confirmed to be almost the same in all cases, then are presented their basicities and the sites of protonation.