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Heo, Ran;Kim, Byung-Ok;Kim, Jeong-Hoon;Kang, Mi-Seon;Jang, Won;Seo, Hee-Young;Park, Ji-Young;Park, Sang-Hoon;Cho, Sung-Woo 인제대학교 2011 仁濟醫學 Vol.32 No.-
알코올의 과다 섭취는 심근 경색의 드문 원인으로, 저자들은 알코올의 과다 섭취 후 발생한 ST 분절 상승 심근 경색 환자에서 정상 관상동맥 소견을 보이는 증례를 보고하는 바이다. 70세 남환이 과음 후 반혼수 상태로 내원하였다. 당시 심전도 및 심근 효소치는 정상이었으나, 2일 후 심전도에서 II, III, aVF, V4-6에 ST 분절 상승과 함께 심근 효소치의 상승을 보였다. 관상동맥 조영술에서 이상 병번은 없었으며, 경흉부 심초음파에서 구혈률은 61.7%였고, 국소 벽운동 장애는 관찰되지 않았다. 알코을은 관상동맥의 연축, 혈견 유발 및 혈관 내피 세포 손상과 연관이 있으나, 알코올에 의한 심근 경색의 기전은 명확하지 앉은 상태이다. 본 증례는 기존의 보고와는 달리 고령에서 발생한 첫 증례로서 ST 분절 상승 상태에서도 정상 관상 동맥 및 정상 심기능을 보였다는 점에 특이성이 있다고 할 수 있다.
Heo, Jaesung,Oh, Young-Taek,Noh, O Kyu,Chun, Mison,Park, Jun-Eun,Cho, Sung-Ran The Korean Society for Radiation Oncology 2016 Radiation Oncology Journal Vol.34 No.4
Purpose: The objective of this prospective study was to evaluate the relationship between the circulating lymphocyte subpopulation counts during preoperative chemoradiotherapy (CRT) and tumor response in locally advanced rectal cancer. Materials and Methods: From August 2015 to June 2016, 10 patients treated with preoperative CRT followed by surgery were enrolled. Patients received conventional fractionated radiotherapy (50.4 Gy) with fluorouracil-based chemotherapy. Surgical resection was performed at 4 to 8 weeks after the completion of preoperative CRT. The absolute blood lymphocyte subpopulation was obtained prior to and after 4 weeks of CRT. We analyzed the association between a tumor response and change in the lymphocyte subpopulation during CRT. Results: Among 10 patients, 2 (20%) had evidence of pathologic complete response. In 8 patients with clinically node positive, 4 (50%) had nodal tumor response. All lymphocyte subpopulation counts at 4 weeks after CRT were significantly lower than those observed during pretreatment (p < 0.01). A high decrease in natural killer (NK) cell, count during CRT (baseline cell count - cell count at 4 weeks) was associated with node down staging (p = 0.034). Conclusion: Our results suggest that the change of lymphocyte subset to preoperative CRT may be a predictive factor for tumor response in rectal cancer.
Heo Young-Ran,Moustaid-Moussa Naima The Korean Society of Community Nutrition 2006 Journal of community nutrition Vol.8 No.2
Adipose tissue has now been recognized as a rich source of metabolically active molecules that include leptin and angiotensinogen (AGT), the precursor of angiotensin II (Ang II). Both of which have been implicated in the pathogenesis of metabolic alteration and hypertension associated with obesity. In this study, we examined the relationship between body mass index (BMI), adipocyte size, leptin, Ang II secretion and mRNA expression in human adipose tissue obtained from female subjects. Leptin and Ang II were analyzed using specific radioimmunoassay kits following a 48hour tissue culture. Leptin and Ang II secretion varied from 1.4 - 72.1ng/g and 0.8 - 57.3pg/g of tissue respectively. These large individual variations limit significant correlation between BMI, leptin and Ang II secretion. Ang II secretion was significantly higher in the obese than the non-obese (p < 0.05) and positively correlated with BMI. However, no difference in leptin secretion between the obese and the non-obese was observed and leptin secretion showed negative correlation with BMI. No difference in leptin and AGT mRNA expression in adipose tissue between the obese and the non-obese was observed. Although several limitations of this study, we found increased Ang II secretion in obese patients compared with non-obese patients, and positive correlation between AGT and BMI. Observed difference in AGT expression between the obese and the non-obese in this study might be of importance in relation with obesity related hypertension. (J Community Nutrition 8(2): 69-75, 2006)