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金弘均,咸泰元,鮮于鍈,孫鐘夏 최신의학사 1972 最新醫學 Vol.15 No.4
A Series of 8 cases of bile peritonitis treated in the 3 year period, Mar. 1969 to Jan. 1972, is presented. In this group, half of the cases were of perforation of acute cholecystitis; other casees were of idio pathic and rupture of subcapsular cholangitic abscess. The chief pathology of the bile peritonitis is induced by a salt of Na. glycocholate and Na. tauro?cholate which irritate, weaken and destroy the peritoneum and serosa so that a serious stage of endotoxic shock may be induced, the diagnosis is difficult. The treatment of bile peritonitis is surgical. 2 deaths occured in this series.
레지오넬라 폐렴의 진단용 바이오마커의 발굴 : A/J 마우스 감염 모델에서 Legionella pneumophila의 독력 유전자들의 발현양상 분석
김승민,심희선,김희남,심호기,윤영경,김정연,박윤선,박대원,손장욱,김민자 대한감염학회 2010 감염과 화학요법 Vol.42 No.1
Background: Legionella pneumophila is the causative agent of Legionnaires’ disease, a severe form of pneumonia. After L. pneumophila is inhaled through contaminated aerosols, it is phagocytized by alveolar macrophages, multiplies in a specialized phagosome approximately 10 h postinfection, and eventually leads to the death of host cells. Currently available diagnostic tests for Legionella pneumonia have some limitations. This study was conducted to find diagnostic biomarkers for Legionella pneumonia using virulence gene expression profiling in a murine experimental model. Materials and Methods: A/J mice were intranasally inoculated with L. pneumophila serogroup 1, and lungs were harvested 4, 8, 24, and 48 h postinfection. The strain grown in buffered yeast extract broth was used as reference samples. Cy-dye labeled cDNA samples were prepared with total RNA from lungs or broth culture, and hybridized on the oligo-microarray slide containing 2,895 genes of L. pneumophila serogroup 1. Virulence gene expression patterns were analyzed using a MIDAS software from TIGR (www.tigr.org). Results: Among a total of 332 virulence genes examined, 17 genes including sidA, lepB, the genes related to flagella assembly (fliR and fliP), LPS lipid A biosynthesis, and the enhanced entry protein EnhA were up-regulated at all four time points. We further confirmed by quantitative real-time reverse transcription PCR that the expression of fliP gene was highly expressed in lung tissue as well as in bronchoalveolar lavage fluids from the mouse infected with L. pneumophila serogroup 1. Conclusions: Through gene expression analysis of L. pneumophila in a mouse model, several candidate biomarkers for diagnosing Legionnaires’ disease could be identified.
마이크로 웨이브에 의한 Albite-Anorthite 이성분계의 결정화 특성
박성수,이종현,이윤복,손영국,김창욱 부산대학교 1995 生産技術硏究所論文集 Vol.48 No.-
The three different compositions of albite (Ab) and anorthite (An) were melted and then held at 1200℃ for 64 h and 128 h in microwave and thermal radiation environments. The amount of crystalline phase for samples processed in a 2.45 GHz microwave field was near zero or much less than that for samples processed in a conventional furnace. These results showed that a microwave field affected the nucleation of plagioclase crystal in its two phase region. Therefore, a 2.45 GHz electromagnetic field could prohibit to form crystalline phase. Albite (Ab)와 anorthite (An)의 세가지 다른 조성들을 마이크로 웨이브와 재래식 열파의 분위기에서 녹인 후 1200℃에서 64시간과 128시간 동안유지시켰다. 2.45GHz 마이크로 웨이브 에너지에 의해서 만들어진 시료 결정상의 양은 재래식 열파에 의해서 만들어진 시료 결정상의 양보다 훨씬 적거나 거의 존재하지 않았다. 그 결과 마이크로 웨이브가 二相영역에서 plagioclase 결정의 핵생성에 영향을 미치므로 2.45 GHz 전자기파가 용융상태에서 결정상의 형성을 저해한다고 추정된다.
An Unusual Type of Cancer-associated Retinopathy in a Patient with Ovarian Cancer
Young H,Yoon,Eun H,Cho,Joon hong Sohn,Charles E,Thirkill 대한안과학회 1999 Korean Journal of Ophthalmology Vol.13 No.1
We studied a case of unusual retinopathy in a 35-year-old woman who presented with bilateral visual deterioration due to retinal pigmentary mottling and serous elevation in the posterior pole. Two years before, she had undergone hysterectomy and bilateral salphingo-oophorectomy for ovarian cancer. Her electroretinogram became subnormal, and her fluorescein angiogram exhibited multiple deep retinal pigment epithelial leakages and subretinal dye pooling in both eyes. Corticosteroid therapy failed to prevent visual loss. She was found to possess antibodies against retinal 45 kd protein. This led to a diagnosis of cancer-associated retinopathy with atypical protein profile. We report a rare variety of cancer-associated retinopathy in a patient with-ovarian cancer.
Park, Jung Won,Min, Hyun Jung,Sohn, Jung Ho,Kim, Joo Young,Hong, Jeong Ho,Sigrist, Kirsten S.,Glimcher, Laurie H.,Hwang, Eun Sook Elsevier 2009 The journal of allergy and clinical immunology Vol.123 No.2
<P><B>Background</B></P><P>A T<SUB>H</SUB>1-specific transcription factor, T-box–containing protein expressed in T cells (T-bet), controls the production of both T<SUB>H</SUB>1 and T<SUB>H</SUB>2 cytokines in T<SUB>H</SUB> cell differentiation by means of distinct mechanisms. T-bet–deficient mice overproduce T<SUB>H</SUB>2 cytokines and have spontaneous airway inflammation.</P><P><B>Objectives</B></P><P>We tested whether T-bet overexpression could protect against the development or progression of asthma.</P><P><B>Methods</B></P><P>We generated a T cell–specific and inducible line of T-bet–transgenic mice on a T-bet–deficient genetic background and used it to study the function of T-bet in an ovalbumin (OVA)–induced asthma model.</P><P><B>Results</B></P><P>Induction of T-bet in a T cell–specific manner in an OVA model of asthma concomitant with OVA injection prevented airway hyperresponsiveness, eosinophilic and lymphocytic inflammation, and IL-5 and IL-13 production in bronchoalveolar lavage fluid and also reduced serum IgE and T<SUB>H</SUB>2 cytokine production by peripheral T cells. Even when T-bet expression was induced during later stages of asthma progression, T-bet overexpression still attenuated airway hyperresponsiveness and goblet cell hyperplasia, as well as T<SUB>H</SUB>2 cytokine production.</P><P><B>Conclusions</B></P><P>Our results suggest that T-bet expression in T cells can prevent the initiation of airway inflammation and progression of chronic inflammation and might be extrapolated to human asthma.</P>
Restoration ofT-box-containing protein expressed in T cells protects against allergen-induced asthma
Eun Sook, Hwang,Jung Won, Park,Hyun Jung, Min,Jung Ho, Sohn,Joo Young, Kim,Jeong Ho, Hong,Kirsten S. Sigrist,Laurie H. Glimcher 이화여자대학교 약학연구소 2010 藥學硏究論文集 Vol.- No.20
BACKGROUND: A T(H)1-specific transcription factor, T-box-containing protein expressed in T cells (T-bet), controls the production of both T(H)1 and T(H)2 cytokines in T(H) cell differentiation by means of distinct mechanisms. T-bet-deficient mice overproduce T(H)2 cytokines and have spontaneous airway inflammation. OBJECTIVES: We tested whether T-bet overexpression could protect against the development or progression of asthma. METHODS: We generated a T cell-specific and inducible line of T-bet-transgenic mice on a T-bet-deficient genetic background and used it to study the function of T-bet in an ovalbumin (OVA)-induced asthma model. RESULTS: Induction of T-bet in a T cell-specific manner in an OVA model of asthma concomitant with OVA injection prevented airway hyperresponsiveness, eosinophilic and lymphocytic inflammation, and IL-5 and IL-13 production in bronchoalveolar lavage fluid and also reduced serum IgE and T(H)2 cytokine production by peripheral T cells. Even when T-bet expression was induced during later stages of asthma progression, T-bet overexpression still attenuated airway hyperresponsiveness and goblet cell hyperplasia, as well as T(H)2 cytokine production. CONCLUSIONS: Our results suggest that T-bet expression in T cells can prevent the initiation of airway inflammation and progression of chronic inflammation and might be extrapolated to human asthma.
Lee, Yoonju,Park, Yeong-Hun,Lee, Jae Jung,Sohn, Young H.,Lee, Jong-Min,Lee, Phil Hyu Elsevier 2018 Parkinsonism & related disorders Vol.52 No.-
<P><B>Abstract</B></P> <P><B>Introduction</B></P> <P>The pattern of resting-state networks is influenced by several factors besides the underlying pathological changes of Parkinson's disease (PD). Uric acid (UA), as an antioxidant, has a neuroprotective property against PD-related microenvironment; however, this effect would be gender-specific. We aimed to evaluate a gender-sensitive resting-state networks (RSN) according to the UA level in drug naïve de novo patients with PD to elucidate the role of antioxidant in cortical functional networks of PD.</P> <P><B>Methods</B></P> <P>This study enrolled 135 de novo patients with PD underwent functional magnetic resonance imaging (MRI). Based on the distribution, the serum UA level was stratified into tertiles in the PD patients by gender. With a seed-based approach, we investigated the pattern of RSN within the dorsal attention network (DAN), executive control network (ECN), and default mode network (DMN).</P> <P><B>Results</B></P> <P>Interaction analysis showed a significant interaction between the lowest (PD-L-UA) and the highest UA level (PD-H-UA) groups according to gender within the DAN, ECN, and DMN. Compared to the control subjects, male patients with PD-H-UA had higher cortical functional connectivity (FC), while female patients had lower cortical FC regardless of UA level within all seeds. In a direct comparison, male patients with PD-H-UA had increased FC than did those with PD-L-UA. However, there was no significant difference in FC between PD-L-UA and PD-H-UA in female PD patients.</P> <P><B>Conclusions</B></P> <P>These data suggest that RSN might be closely and gender-specifically associated with the status of serum UA in de novo PD patients.</P> <P><B>Highlights</B></P> <P> <UL> <LI> We present fMRI data from 135 drug naïve de novo patients with PD. </LI> <LI> Male patients with higher UA levels had higher corticalfunctional connectivity. </LI> <LI> In contrast, female patients had lower functional networks regardless of UA level. </LI> <LI> Serum UA might influence RSN closely and gender-specifically in PD patients. </LI> </UL> </P>