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광중합형 복합레진 제조시의 압축강도에 관한 실험적 연구
배태성,추용호,채민수 大韓齒科器材學會 1995 대한치과재료학회지 Vol.22 No.2
This study was performed to elaluate the effect of matrix resins and fillers on the compressive strength of light-activated composite resins. Four different types of composites were made by mixing the inorganic fillers of armorphous spherical silica and crushed quartz with resins of BisGMA/TEGDMA and UTeMA/TEGDMA. The specimens of 3mm in diameter and 6mm in length were prepared. Compressive test was subjected to a crosshead speed of 0.5mm/min and fracture surfaces were examined by SEM. The results obtained were summarized as follows; 1. Compressive strength of the UTeMA-based composite resin with spherical filler was superior to the other composite resins(p<0.01). 2. Compressive strength of the BisGMA-based composite resins with significantly decreased after immersion in water for 7 days(p<0.05). 3. UTeMA-based composite resins showed the aspect of decrease in compressive strength after cold storage at 5℃.
우측 경부에 발생한 제 1 새열낭종 ( Type 1 ) 의 치험례
주영채(Young Chae Chu),이성준(Seong Jun Lee),하수용(Soo Yong Ha),김일규(Il Kyu Kim) 대한악안면성형재건외과학회 1990 Maxillofacial Plastic Reconstructive Surgery Vol.12 No.1
This is a case report of first branchial cleft cyst in 56 year old male patient, which was tentatively diagnosed as acute right submandibular abscess resulted from the periapical lesion of the lower right second molar. The results are as follows, 1. The accompanying ipsilateral inflammatory swelling resulted from the periapical lesion of lower right second molar tooth makes the diagnosis difficult 2. The onset of this case was very late in comparison to the mean discovering age of branchial cleft cysts. 3 The plain radiography using contrast media is helpful for the diagnosis of cystic lesions within soft tissues. 4 This case is a first branchial cleft cyst (Type I) which occurs less than 1% of all branchial deft anomalies.
최소영(So Young Choi),김세중(Sei Joong Kim),조영업(Young Up Cho),박재영(Jae Young Park),박정미(Jeong Mi Park),주영채(Young Chae Chu),최윤미(Yun Mee Choe),최선근(Sun Keun Choi),허윤석(Yoon Seok Heo),이건영(Keon Young Lee),안승익(Seung 대한외과학회 2009 Annals of Surgical Treatment and Research(ASRT) Vol.76 No.5
Purpose: Apocrine carcinoma of the breast is rare and there is confusion about the criteria of its histopathologic diagnosis. The purpose of this study is to investigate the clinical and pathologic characteristics of the disease. Methods: 9 patients diagnosed with apocrine carcinoma or apocrine carcinoma in situ and 1,009 patients diagnosed with non-apocrine carcinoma of the breast from April 1999 to March 2008 were retrospectively analyzed. Results: The mean age of the patients with apocrine carcinoma was 52.3 year. 5 patients (55.6%) among 9 patients with apocrine carcinoma were postmenopausal. There were 2,1 and 6 patients with stage 0, Ⅰ and Ⅱ disease, respectively according the TNM stage. These demographic and clinical differences between the patients with apocrine carcinoma and non-apocrine carcinoma were not significant. Only four patients (44.4%) were preoperatively diagnosed with apocrine carcinoma or apocrine carcinoma in situ. By surgical biopsy, additional 5 patients were diagnosed as apocrine carcinoma. In the immunohistochemical study, Bcl-2 was positive in one (12.5%) of 8 patients. p53 was positive in 4 (44.4%) of 9 patients. Expressions of estrogen and progesterone receptor were positive only in two patients (22.2%) with weakly positive staining. Androgen receptor was positively expressed in all cases (100%) of apocrine carcinoma. Overexpression of c-erb-B2 was detected in four patients. Conclusion: Treatment modality and prognosis of apocrine carcinoma are similar as non-apocrine carcinoma. But its preoperative diagnosis is more difficult than that of non-apocrine carcinoma and it shows different expression of hormone receptor. Further study is needed for the development of new hormonal therapy using androgen.
A Bacterial Metabolite, Compound K, Induces Programmed Necrosis in MCF-7 Cells via GSK3β
( Chae Won Kwak ),( Young Min Son ),( Min Jeong Gu ),( Girak Kim ),( In Kyu Lee ),( Yoon Chul Kye ),( Han Wool Kim ),( Ki Duk Song ),( Hyuk Chu ),( Byung Chul Park ),( Hak Kyo Lee ),( Deok Chun Yang ) 한국미생물 · 생명공학회 2015 Journal of microbiology and biotechnology Vol.25 No.7
Ginsenosides, the major active component of ginseng, are traditionally used to treat various diseases, including cancer, inflammation, and obesity. Among these, compound K (CK), an intestinal bacterial metabolite of the ginsenosides Rb1, Rb2, and Rc from Bacteroides JY-6, is reported to inhibit cancer cell growth by inducing cell-cycle arrest or cell death, including apoptosis and necrosis. However, the precise effect of CK on breast cancer cells remains unclear. MCF-7 cells were treated with CK (0-70 μM) for 24 or 48 h. Cell proliferation and death were evaluated by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) and flow cytometry assays, respectively. Changes in downstream signaling molecules involved in cell death, including glycogen synthase kinase 3β (GSK3β), GSK3β, β-catenin, and cyclin D1, were analyzed by western blot assay. To block GSK3β signaling, MCF-7 cells were pretreated with GSK3β inhibitors 1 h prior to CK treatment. Cell death and the expression of β-catenin and cyclin D1 were then examined. CK dose- and time-dependently inhibited MCF-7 cell proliferation. Interestingly, CK induced programmed necrosis, but not apoptosis, via the GSK3β signaling pathway in MCF-7 cells. CK inhibited GSK3β phosphorylation, thereby suppressing the expression of β-catenin and cyclin D1. Our results suggest that CK induces programmed necrosis in MCF-7 breast cancer cells via the GSK3β signaling pathway.
Chae, Mi-Kyung,Kim, Ji-Young,Chu, Jia-Qi,Kim, Duck-Hwan,Yoo, Han-Sang,Park, Chang-Sik,Kim, Myung-Cheol,Jun, Moo-Hyung The Korean Society for Microbiology 2006 Journal of Bacteriology and Virology Vol.36 No.1
Swine hepatitis E virus (HEV) has been reported as a new zoonotic agent due to its close genomic resemblance to the human HEV. Recently this virus is indicated as one of the important pathogens in xenotransplantation that uses pig as a donor animal. We carried out to investigate the prevalence of HEV infections among the pigs and human population in Chungnam region using a nested RT-PCR for detection of a part of HEV ORF2 gene. The sequences of the amplified DNA were analyzed and the genetical divergency were characterized. A total of 18 HEV strains, comprising 16 strains from pig and 2 strains from human, were genetically isolated from the fecal and serum samples. Among the isolates, 5 strains (2.5%) were detected from 200 swine sera and 2 strains (2.0%) from 100 human sera. All of the 16 swine strains were isolated from the pigs at 3 month of age, but none of age groups revealed the positive for swine HEV RNA. In comparison of the nucleotide sequence between 16 swine HEV and 2 human HEV isolates, the range of identities was 91.5% to 100%. Two human HEV isolates shared 99.7% homology. In phylogenetic analysis, all of the isolates were classified into genotype III, and the 18 isolates were also closely related to the prototype of swine HEV and human HEV strains isolated in the United States and others recently identified from swine in Japan and Netherland.