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- 저자 : Young Ah Oh (검색결과 768 건)
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실험적 진폐증에서 투여약제에 따른 면역학적 병리학적 조직변화
윤임중,임현우,노영만,오상용,정장영,임영,김경아 가톨릭 대학 산업의학 쎈타 산업의학연구소 1993 韓國의 産業醫學 Vol.32 No.2
To access the effects of some drugs such as piperazine phosphare, azathioprine and allopurinol in the experimental pneumoconiosis, 263 rats weighted 240-320 gm was divided into the control and eight experimental groups. To each group, the turbid solution mixed free silica, talc and natural coal dust of 50 mg in 0.8 ml saline were instilled intratracheally. At the begining and 5th week of experiment, piperazine phosphate(8mg/week orally), aspirin(1.5mg/day intramuscularly), azathioprine(25mg/day orally) and allopurinol(1.5mg/day orally) were administered simultaneously, while the dust turbid solution was only given to the control group. For each group the change of body weight. dry right lung weight, cellularity including total cell, macrophage, lymphocyte and neurtrophil in bronchoalveolar lavage fluid, superoxide ion, hydroxyproline, leukotriene B₄, tumor necrotsis factor, prostaglandin E₂were examined, and observed the pathological chages in lung tissue. The results were as follow : 1. The larger amount of their instilled dust and the longer observation period, the severer pathological findings were found in the lung tissue of each experimental group. 2. The body and dry right lung wight was not significantly changed in the experimental groups compared with the control group. 3. The number of total cell in bronchoalveolar lavage fluid was markedly less in the experimental group than the control one, while no significant difference was found in the percent alveolar macrophages and lymphocytes in both groups. However, the percent of neutrophiles was usually lower than in the control group. 4. The amount of superoxide ion was frequently less in the experimental group compared with the control one. 5. The amount of hydroxyproline was significantly lower in the experimental group than in the control one. 6. The amount of leukotriene B₄was usually less in the drug administered group than in the control one. 7. The amount of tumor necrotic factor was also frequently lower in each experimental group than in the control one. 8. The amount of prostaglandin E₂was usually higher in each experimental group than in the control one.
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정종철,최홍란,오희균,박준아,류선열,이종호,김영운,정숭룡 大韓顎顔面成形再建外科學會 1995 Maxillofacial Plastic Reconstructive Surgery Vol.17 No.3
Malignant fibrous histiocytoma rarely occurs in the jaws. Although the histogenesis of this tumor remains controversal, it is best regarded as a primitive and pleomorphic nature reflected by collagen production and occasional phagocytosis. It is common for metastatic foci to appear in lung and regional lymph node. There are variable treatments such as radiotherapy, surgical excision or combination, therapy of surgical excision, chemotherapy and radiotherapy. With the review of literatures, the authors report the clinical study of two cases of malignant fibrous histiocytoma of the jaw.
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광물성 섬유의 수산이온기 생성이 흰쥐 폐포대식세포의 세포독성과 적혈구 세포막의 지질과산화에 미치는 영향
김경아,윤임중,김지홍,장황신,오민화,임영,박정일 大韓産業醫學會 1997 대한직업환경의학회지 Vol.9 No.3
There is some evidence suggesting that the mechanism of pulmonary toxicity of natural fibrous silicate, asbestos, is related to the generation of oxygen-based free radical. Especially the hydroxyl radical(·OH) is believed to be the most reactive one. ·OH is a potent toxic oxidant, ·OH is which means highly cytotoxic, genotoxic and carcinogenic. Nevertheless there has been no previous report about ·OH generation from man-made mineral fibers except asbestos. In this paper we tested the hypothesis that both cytotoxicity of alveolar macrophage and lipid peroxidation of erythrocytes are associated with ·OH production by mineral fibers in vitro. The results were as follows: 1. ·OH production in vitro was progressively increased by the concentration dependent pattern with the same mineral fiber. The production of ·OH in vitro by man-made mineral fiber was markedly decreased compared with that of natural mineral fiber except rock wool. 2. Lipid peroxidation of mineral fiber-exposed erythrocyte suspension was significantly increased compared with that of phosphate-buffered saline(PBS) control group. Lipid peroxidation in amosite and chrysotile group was larger than that of other mineral fibers. 3. There was a significantly positive correlation between ·OH production in vitro and lipid peroxidation of mineral fiber-exposed erythrocyte. 4. All of mineral fibers were related to the cytotoxicity of alveolar macrophage in concentration-dependent fashion. Chrysotile and amosite were more cytotoxic than crocidolite. Among man-made mineral fibers, ceramic fiber was the most cytotoxic to alveolar macrophage. The viability of alveolar macrophage exposed to asbestos was markedly decreased compared with that of man-made mineral fiver at the same concentration. 5. There was the significant negative correlation between the production of .OH and the viability of alveolar macrophages. From these results, we can conclude that the production of ·OH in vitro was strongly correlated with the cytotoxicity of alveolar macrophage and the lipid peroxidation in mineral fiber-exposed erythrocyte. And we documented that man-made mineral fiber could generate .OH in vitro less than asbestos.
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Association of vitamin D concentrations with adiposity indices among preadolescent children in Korea
Lee, Hye Ah,Kim, Young Ju,Lee, Hwayoung,Gwak, Hye Sun,Park, Eun Ae,Cho, Su Jin,Oh, Se Young,Ha, Eun Hee,Kim, Hae Soon,Park, Hyesook Walter de Gruyter GmbH 2013 Journal of pediatric endocrinology & metabolism Vol.26 No.9
<P>Background and Objective: We aimed to investigate the association between serum 25-hydroxyvitamin D (25(OH)D) and anthropometric indicators of adiposity among Korean preadolescent children aged 7?9 years. Subjects and Methods: Children aged 7 to 9 from the Ewha Birth & Growth Cohort were followed up from July to August 2011. Serum 25(OH)D concentration was measured using radio immunoassay. We assessed the magnitude of cross-sectional association with vitamin D concentrations and indicators of adiposity [body mass index (BMI), waist circumference (WC), mid-arm circumference (MAC), body fat mass (BFM), percent body fat (PBF), and triceps skinfold thickness (TSF)] using multiple linear and logistic regression analyses adjusted for sex, age, birth order, maternal education, and fruit/fruit juice intake. Results: Thirty-two (16%) out of a total of 205 children showed an optimal level of serum 25(OH)D, but most children did not reach a sufficient level (<30 ng/mL) even in summer. The level of 25(OH)D was inversely associated with BMI (β=?0.10, p<0.01), WC (β=?0.28, p<0.01), and BFM (β=?0.12, p=0.02) after adjusting for confounding factors and showed marginal boundary with PBF (β=?0.20, p=0.06) and TSF (β=?0.11, p=0.08). Regarding the risk of overweight, a 13% protective effect per 1 ng/mL increase of 25(OH)D was shown even after adjusting for relevant confounding factors (adjusted odds ratio=0.87, 95% confidence interval 0.78?0.98). Conclusions: We found that the 25(OH)D concentrations were inversely associated with adiposity indices in preadolescent children. This study suggests that adequate vitamin D intake in growing children is crucial to maintain an optimal vitamin D level to prevent obesity and obesity-related health problems later in life.</P>
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Oh, Young Hoon,Eom, Gyeong Tae,Kang, Kyoung Hee,Joo, Jeong Chan,Jang, Young-Ah,Choi, Jae Woo,Song, Bong Keun,Lee, Seung Hwan,Park, Si Jae Springer-Verlag 2016 BIOPROCESS AND BIOSYSTEMS ENGINEERING Vol.39 No.4
<P>Gene-expression cassettes for the construction of recombinant Clostridium beijerinckii were developed as potential tools for metabolic engineering of C. beijerinckii. Gene expression cassettes containing ColE1 origin and pAMB origin along with the erythromycin resistance gene were constructed, in which promoters from Escherichia coli, Lactococcus lactis, Ralstonia eutropha, C. acetobutylicum, and C. beijerinckii are examined as potential promoters in C. beijerinckii. Zymogram analysis of the cell extracts and comparison of lipase activities of the recombinant C. beijerinckii strains expressing Pseudomonas fluorescens tliA gene suggested that the tliA gene was functionally expressed by all the examined promoters with different expression level. Also, recombinant C. beijerinckii expressing C. beijerinckii secondary alcohol dehydrogenase by the constructed expression cassettes successfully produced 2-propanol from glucose. The best promoter for TliA expression was the R. eutropha phaP promoter while that for 2-propanol production was the putative C. beijerinckii pta promoter. Gene expression cassettes developed in this study may be useful tools for the construction of recombinant C. beijerinckii strains as host strains for the valuable chemicals and fuels from renewable resources.</P>
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Ah Young Oh,Chong Sung Kim,Kwang Suk Seo,Hee Soo Kim 대한마취과학회 2007 Korean Journal of Anesthesiology Vol.53 No.6
Background: It is well documented that BIS reflects the level of sedation but conflicting results exist about whether BIS can reflect the depth of anesthesia. We intended to identify this issue by investigating the correlation between the pre-incision bispectral index (BIS) values and the hemodynamic responses to skin incision during sevoflurane-N2O anesthesia in children. Methods: In total, 117 ASA physical status I or II pediatric patients, aged 6 mo-12 yr, were enrolled. After induction and intubation with thiopental, rocuronium, sevoflurane and N2O, patients were randomly allocated to one of the four end-tidal sevoflurane concentrations (ETsevo); 2.0, 2.5, 3.0, and 3.5 %; with 60% N2O. The ETsevo was maintained constant for more than 15 min before and 5 min after skin incision. BIS, heart rate (HR), and systolic arterial pressure (SAP) before and after skin incision were recorded. Results: Although there were no correlation between pre-incision BIS and change in BIS, SAP, and HR (Pearson`s coefficient -0.120, -0.102, and -0.080, respectively), there were correlations between changes of BIS and changes in SAP and HR (Pearson`s coefficient 0.318 and 0.309, respectively, P < 0.05). Conclusions: There was a correlation between the change of BIS, but not BISpre, and change in hemodynamic variables with skin incision during sevoflurane anesthesia in children. (Korean J Anesthesiol 2007; 53: S 26∼30)
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ChREBP deficiency leads to diarrhea-predominant irritable bowel syndrome
Oh, Ah-Reum,Sohn, Seonyong,Lee, Junghoon,Park, Jong-Min,Nam, Ki Taek,Hahm, Ki-Baik,Kim, Young-Bum,Lee, Ho-Jae,Cha, Ji-Young Elsevier 2018 clinical and experimental Vol.85 No.-
<P><B>Abstract</B></P> <P><B>Objective</B></P> <P>Fructose malabsorption is a common digestive disorder in which absorption of fructose in the small intestine is impaired. An abnormality of the main intestinal fructose transporter proteins has been proposed as a cause for fructose malabsorption. However the underlying molecular mechanism for this remains unclear. In this study, we investigated whether carbohydrate response element-binding protein (ChREBP) plays a role in intestinal fructose absorption through the regulation of genes involved in fructose transport and metabolism and ion transport.</P> <P><B>Methods</B></P> <P>Wild type (WT) and <I>Chrebp</I> knockout (KO) mice (6 or 8 weeks old) were fed a control diet (55% starch, 15% maltodextrin 10) or high-fructose diet (HFrD, 60% fructose, 10% starch) for 3–12 days. Body weight and food intake were measured, signs of fructose malabsorption were monitored, and the expression of genes involved in fructose transport/metabolism and ion transport was evaluated. Furthermore, transient transfection and chromatin immunoprecipitation were performed to show the direct interaction between ChREBP and carbohydrate response elements in the promoter of <I>Slc2A5</I>, which encodes the fructose transporter GLUT5.</P> <P><B>Results</B></P> <P> <I>Chrebp</I> KO mice fed the control diet maintained a constant body weight, whereas those fed a HFrD showed significant weight loss within 3–5 days. In addition, <I>Chrebp</I> KO mice fed the HFrD exhibited a markedly distended cecum and proximal colon containing both fluid and gas, suggesting incomplete fructose absorption. Fructose-induced increases of genes involved in fructose transport (GLUT5), fructose metabolism (<I>fructokinase</I>, <I>aldolase B</I>, <I>triokinase</I>, and <I>lactate dehydrogenase</I>), and gluconeogenesis (<I>glucose</I>-<I>6</I>-<I>phosphatase</I> and <I>fructose</I>-<I>1</I>,<I>6</I>-<I>bisphosphatase</I>) were observed in the intestine of WT but not of <I>Chrebp</I> KO mice. Moreover the Na<SUP>+</SUP>/H<SUP>+</SUP> exchanger NHE3, which is involved in Na<SUP>+</SUP> and water absorption in the intestine, was significantly decreased in HFrD-fed <I>Chrebp</I> KO mice. Consistent with this finding, the high-fructose diet-fed <I>Chrebp</I> KO mice developed severe diarrhea. Results of chromatin immunoprecipitation assays showed a direct interaction of ChREBP with the <I>Glut5</I> promoter, but not the <I>Nhe3</I> promoter, in the small intestine. Ectopic co-expression of ChREBP and its heterodimer partner Max-like protein X activated the <I>Glut5</I> promoter in Caco-2BBE cells.</P> <P><B>Conclusions</B></P> <P>ChREBP plays a key role in the dietary fructose transport as well as conversion into lactate and glucose through direct transcriptional control of genes involved in fructose transport, fructolysis, and gluconeogenesis. Moreover, ablation of <I>Chrebp</I> results in a severe diarrhea in mice fed a high-fructose diet, which is associated with the insufficient induction of GLUT5 in the intestine.</P> <P><B>Highlights</B></P> <P> <UL> <LI> <I>Chrebp</I> knockout mice show intestinal fructose malabsorption upon high-fructose feeding. </LI> <LI> ChREBP deficiency leads to a severe diarrhea and weight loss upon high-fructose feeding. </LI> <LI> GLUT5 and intestinal fructolytic genes are not induced by fructose in <I>Chrebp</I> knockout mice. </LI> <LI> ChREBP directly regulates <I>Glut5</I> gene expression through binding to functional ChoREs. </LI> </UL> </P>
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