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신두리 해안사구에 자생하는 사구식물 내생진균의 다양성 분석
유영현 ( Youn Hyun You ),서영교 ( Yeong Gyo Seo ),윤혁준 ( Hyeok Jun Yoon ),김현 ( Hyun Kim ),김예은 ( Ye Eun Kim ),이리나할무라토바1 ( Irina Khalmuratova ),임순옥 ( Soon Ok Rim ),김창무 ( Chang Mu Kim ),김종국 ( Jong Guk Kim ) 한국미생물생명공학회(구 한국산업미생물학회) 2013 한국미생물·생명공학회지 Vol.41 No.3
The coastal sand-dune plants of eight species; Argusia sibirica, Calystegia soldanella, Elymus mollis, Lithospermum zollingeri, Raphanus sativus, Salsola collina, Zoysia macrostachya, and Zoysia sinica were collected from the Shindu-ri coastal sand dune. Ninety-eight endophytic fungal strains were isolated from the roots of these plants, analyzed, and identified by sequences in their internal transcribed spacers (ITS) at the ITS1, 5.8S, and ITS2 regions. The diversity of endophytic fungi isolated from coastal sand-dune plants was confirmed with various diversity indices. The fungal strains belonged to thirteen orders: Capnodiales (3.09%), Eurotiales (70.10%), Glomerellales (1.03%), Helotiales (3.09%), Hypocreales (9.28%), Mortierellales (2.06%), Onygenales (1.03%), Ophiostomatales (1.03%), Pleosporales (1.03%), Polyporales (1.03%), Russulales (1.03%), Saccharomycetales (2.06%), and Xylariales (1.03%). Of the endophytic fungal strains collected, Penicillium (59.18% in Eurotiales) and Fusarium (5.10% in Hypocreales) were the most abundant in coastal sand-dune plants. The endophytic fungal strains isolated from C. soldanella were more diverse compared to strains from the other coastal sand-dune plants
치료 불응성 갑상선암에 대한 실험적 치료 약제: Histone Deacetylase Inhibitor, PPAR-gamma Agonist, Retinoic Acid
정웅윤,OrloHClark<SUP>1<,SUP>,Woung Youn Chung and Orlo H Clark,<SUP>1<,SUP> 대한갑상선-내분비외과학회 2005 The Koreran journal of Endocrine Surgery Vol.5 No.2
Most patients with thyroid cancer have well differentiated tumors that usually respond to conventional therapy including total or near total thyroidectomy, radioiodine ablation and TSH suppression. About 10% of patients, however, have aggressive cancers as a consequence of de-differentiation. During de-differentiation, thyroid cancers not only show more mitosis, fibrosis, and altered cell structure, they also lose thyroid-specific functions (iodine uptake, TSH receptor expression, and thyroglobulin production). These poorly differentiated or undifferentiated tumors mostly fail to take up radioiodine and are responsible for most deaths from thyroid cancer. New therapies need to be developed for patients with these types of tumors. Among the most promising antineoplastic therapies for these poorly differentiated and undifferentiated thyroid cancers are the histone deacetylase inhibitors, the PPAR-gamma agonist and retinoic acids. These drugs have therapeutic effects for thyroid cancers in inhibiting growth and inducing apoptosis and redifferentiation, in vivo and in vitro studies. And, clinical trials in patients with refractory thyroid cancers have been initiated. Further laboratory investigation of these drugs is necessary to understand molecular mechanisms and demonstrate therapeutic efficacy for thyroid cancers. (Korean J Endocrine Surg 2005;5:69-74)
종격동 전이를 보이는 갑상선암 환자에서 Robot-assisted Lymph Node Dissection을 병행한 1예
정종주,이용상,강상욱,성태연,이승철,남기현,장항석,정웅윤,백효채<SUP>1<,SUP>,박정수,Jong Ju Jeong,Yong Sang Lee,Sang- Wook Kang,Tae-Yon Sung,Seung Chul Lee,Kee-Hyun Nam,Hang-Seok Chang,Woong Youn Chung,Hyo Chae Paik,<SUP>1<,SUP> and 대한갑상선-내분비외과학회 2008 The Koreran journal of Endocrine Surgery Vol.8 No.2
Lipolysis Effect of Daucosterol Isolated from Mulberry (Morus alba) Leaves
Ke Li1(이커),Mi Lim Lee(이미림),Lu Que(루쿼),Mae Li(이매),Jum Soon Kang(강점순),Yung Hyun Choi(최영현),Kyung Mi Kim(김경미),Jae-Chul Jung(정재철),Dae Youn Hwang(황대연),Young Whan Choi(최영환) 한국생명과학회 2017 생명과학회지 Vol.27 No.12
뽕나무는 약 40여 속과 1,000여 종이 있는 것으로 알려져 있으며, 항염증, 항진정, 지사작용, 노화억제 및 신경보호작용이 있는 것으로 알려져 있다. 본 연구에서는 아시아 지역에서 전통 한약재로 사용되는 뽕 나무 잎의 지방분해 활성에 관여하고 있는 물질을 스크린하기 위하여 뽕잎 분말을 헥산, 에틸 아세테이트 및 메탄올로 순차 추출하였다. 뽕 잎의 EtOAc 추출물로부터 daucosterol이 순수분리 되었으며, 그 구조는 1H, 13C, DEPT, COSY, HSQC 및 HMBC 등의 NMR스펙트럼 분석에 의해 밝혀졌다. Daucosterol은 농도 의존적으로 지질분해 효과를 나타내었는데, 본 연구의 결과로부터 뽕나무 잎으로부터 순수분리한 daucosterol의 지분분해 활성은 다양한 질병을 치료하기 위한 천연물 소재 또는 지표성분으로서 활용이 가능할 것으로 생각된다. 그러나 보다 효율적으로 이용하기 위해서는 daucosterol의 비만에 관한 생리활성 기작에 대한 추가적인 연구가 필요할 것이다. Plants are reservoirs of naturally occurring chemical compounds and of structurally diverse bioactive molecules. The aim of this investigation was to screen for the presence of phytochemicals responsible for the lipolysis activity in mulberry (Morus alba) leaves, which are important in traditional Asian medicinal plants. Powdered mulberry leaves were extracted with hexane, ethyl acetate, and methanol. Daucosterol was isolated from the EtOAc extract of mulberry leaves, and its structure was elucidated by NMR spectral analyses. The NMR assignments for the compound were determined using 1H, 13C, DEPT, COSY, HSQC, and HMBC NMR spectral data. Daucosterol showed a concentration-dependent lipolysis activity that may impart medicinal properties that can be exploited by medical practitioners for the treatment of various diseases. However, further studies should be conducted to elucidate additional mechanisms of daucosterol.
K-IFRS 도입에 따른 자산재평가의 공시효과와 정보적 가치에 대한 결정요인
김경순(제1저자) ( Kyung Soon Kim ),이진훤(교신저자) ( Jin Hwon Lee ),조장연(공동저자) ( Jang Youn Cho ) 한국회계학회 2015 會計學硏究 Vol.40 No.3
본 연구는 K-IFRS 도입에 따른 자산재평가의 정보적 가치를 분석하기 위해 자산재평가 공시일 전, 후의 초과수익률반응을 조사하고, 재평가 공시효과에 영향을 미치는 결정요인을 분석하였다. 특히 본 연구는 다음과 같은 측면에 초점을 두었다. 첫째, 재평가 공시종류(실시공시, 결과공시)와 재평가대상자산(토지와 감가상각자산)에 따라 투자자들이 자산재평가의 정보적 가치를 차별적으로 인식하는지를 분석한다. 둘째, 재평가차익(재평가금액-장부금액)과 비기대재평가차익(재평가금액-공시지가)의 크기에 따라 투자자들이 자산재평가의 정보적 가치를 상이하게 인식하는지를 분석한다. 셋째, 경영자의 이익조정행태에 따라 자산재평가의 공시효과가 차별적인지를 분석한다. 실증분석을 위해 본 연구에서는 2009년 4월 1일부터 2011년 12월 31일까지 재평가 공시가 존재하는 기업을 대상으로 재평가 공시일 전, 후 규모조정 초과수익률을 측정한 후 누적초과수익률에 대한 결정요인을 회귀분석으로 분석하였다. 분석 결과를 요약하면 다음과 같다. 첫째, 재평가에 대한 공시효과는 주로 재평가 실시공시에서 발생하였다. 특히 토지만 재평가한 기업은 재평가 실시공시 시점에 양의 누적초과수익률을 보였지만 감가상각 자산을 포함하여 재평가한 기업은 유의한 주가반응을 보이지 않았다. 둘째, 재평가차익에 대한 주가반응은 유의하지 않았고, 비기대재평가차익(재평가금액-공시지가)은 결과공시 시점의 누적초과수익률과 음의 관계를 나타냈다. 셋째, 이익조정행태가 큰 기업이 자산재평가를 실시할 경우 재평가 공시시점의 누적초과수익률이 감소하였다.전체적으로 K-IFRS에 따른 재평가에 대한 공시효과는 토지에 대한 재평가에서 유효하게 발생하였다. 또한 투자자들이 경영자의 재평가동기와 공정가치평가의 정보적 가치를 재평가차익의 속성과 이익의 질에 따라 차별적으로 해석하고 있음을 발견하였다. 본 연구는 최근 K-IFRS의 시행에 따른 공정가치평가의 유용성을 자산재평가의 공시효과를 이용해 평가하였다는 점과 재평가의 정보적 가치에 영향을 미치는 결정요인을 시장반응을 이용하여 검증하였다는 점에서 의의가 있다. This study analyzes the informativeness of the asset revaluation announcement in accordance with K-IFRS. Korean regulations regarding asset revaluations are categorized into those dealing with ``plan`` announcements and ``result`` announcements. Therefore, the informativeness of asset revaluations are analyzed by using the changes in stock prices, with such uniquely Korean characteristics as plan and asset announcements in mind. In addition, various determinants which could impact the announcement effect of asset revaluations are analyzed. The specific research focus of this study is as follows; first, to determine whether investors discriminately recognize the informativeness of asset revaluations by their type. Second, to determine whether investors differently recognize the informativeness of asset revaluations by the characteristics innate to revaluation margins. Third, to determine whether the announcement effect of asset revaluations differs by earnings management. For an empirical analysis, this study use 233 samples from 2009~2011 whose revaluation announcements still exist and analyzed their size-adjusted abnormal returns from 11 days before & after the announcement date. Also, for 210 of those samples, a regression analysis is performed on the determinants of the changes in the stock prices around the revaluation announcement dates. The analytic results of this study can be summarized as follows; first, the changes in the stock prices 11 days before & after the revaluation plan announcement date show a statistically significant positive value, whereas the changes in the stock prices 11 days before & after the revaluation result announcement show none. Also, the announcement effect of the revaluation plan take place only for those companies which revaluated their lands, whereas the revaluation announcementscontaining depreciable assets do not show any significant changes in stock prices. These results suggest that investors discriminately recognize the informativeness of managers`` signals and fair valuations by revaluation assets`` types. Second, those firms with significant abnormal asset revaluation gain or loss (revaluation value - market value) showed less changes in the stock prices than those without. They suggest that investors recognize the asset revaluations as opportunistic behaviors if the revaluations take place when they are significantly larger than their market values. Third, the changes in stock prices according to asset revaluations are smaller when the level of earnings management is larger. This suggests that investors negatively recognize the asset revaluations of those companies with large earnings managements. Overall, the announcement effect of the asset revaluations in accordance with K-IFRS is statistically significant in land revaluations. Also, it was discovered that investors discriminately interpret the managers`` motives for revaluation plan and the informativeness of fair valuations according to the characteristics innate to revaluation margins and earnings quality. This study is significant in that it verifies the informativeness of asset revaluations in accordance with the latest K-IFRS.
장항석<SUP>1<,SUP>,박준성<SUP>2<,SUP>,정웅윤<SUP>2<,SUP>,박정수<SUP>2<,SUP>,Hang-Seok Chang,M,D,<SUP>1<,SUP>,Jun Sung Park,M,D,<SUP>2<,SUP>,Woung Youn Chung,M,D,<SUP>2<,SUP> and Cheong Soo Park,<SUP> <,SUP>M,D,<S 대한갑상선-내분비외과학회 2001 The Koreran journal of Endocrine Surgery Vol.1 No.1
Bronchogenic cyst can be found about everywhere in the mediastinum and rarely in the abdomen. Embriologically, the bronchogenic cyst, one of the primitive foregut-derived developmental anomalies, is composed of any or all of the tissue elements seen in a bronchus including respiratory epithelium, smooth muscle, mixed serous and mucose glands and cartilage. Most bronchogenic cysts are asymptomatic. The diagnosis is therefore made either as an incidental finding or, more usually is secondary to other organic complications such as infection, hemorrhage, compression of adjacent organs. Only a few of subdiaphragmatic bronchogenic cyst have been reported and their occurrence in the retroperitonum is extremely rare. We present a case of retroperitoneal bronchogenic cyst presenting as adrenal tumor which was successfully treated by laparoscopic resection. (Korean J Endocrine Surg 2001;1:122-124)