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      • KCI등재

        Detection of Genotype associated with Disease Activity and Development of Probe

        Jang,S. I.,Yoo,S. K.,Im,M. K.,Kim,J. H.,Kim,W. S.,You,Y. O.,Lee,D. K.,Kim,K. J.,Kim,W. S. 大韓顎顔面成形再建外科學會 1994 Maxillofacial Plastic Reconstructive Surgery Vol.16 No.4

        질환성과 관련된 세균의 분포 및 유전자형을 탐색하고자 구강농양 및 골수염의 급성감염 혼자와 진료실 및 실험실의 정상인을 대상으로 시료를 채취하여 포도상구균을 분리 및 동정을 시행하고, 특성을 규명하였으며, plasmid 및 염색유전자를 분리하여 제한효소를 처리후 전기영동을 실시하고 분리된 plasmid로 탐색자를 제작하여 dot blot을 시행하였다. 대부분의 급성환자에서 분리된 포도상구균을 S. lugdunensis와 S. aureus이었으나, 진료실 및 실험실에서는 coagulase 음성 staphylococci가 분리되었다. 급성환자에서 분리된 포도상구균은 ampicillin과 penicillin에 내성을 보였다. 분리된 S. lugdunensis균주중 네 균주는 δ형의 용혈소를 생산하였다. Plasmid를 분리한 결과 S. lugdunensis균주중 세 균주는 약 6.5 kilobases이었으나 S. aureus는 약 4.3 kilobases 정도 크기의 band를 보였다. S. lugdunensis에서 분리된 plasmid로 제작한 탐색자로 dot blot를 시행한 결과 치과 영역에서 분리한 plasmid를 갖는 균주는 양성반응을 보였다. 염색체유전자의 유전자형을 분석한 결과 δ형의 용혈소를 생산한 네 균주의 S. lugdunensis는 유사한 유전자형을 보였다. 이러한 연구결과 질환의 진행에 S. lugdunensis가 중요한 역할을 하는 것으로 생각되고, 치과영역에 존재하는 plasmid는 공통적인 유전자 서열을 갖는 것으로 추정된다.

      • Dependence of the exchange bias and coercivity of [Pd/Ferromagnet]<sub>N</sub>/FeMn multilayers on the stack number N

        Joo, H.W.,Lee, M.S.,Kim, S.W.,Kim, S.S.,Lee, J.Y.,Baek, J.Y.,You, C.-Y.,Lee, K.A.,Rhee, J.R.,Lee, S.S.,Hwang, D.G. IEEE 2006 IEEE transactions on magnetics Vol.42 No.10

        The dependencies of the stack number N on perpendicular exchange-biasing (H<SUB>ex</SUB>) and coercivity H<SUB>c</SUB>) in [Pd/Co]<SUB>N</SUB> and [Pd/Co (or CoFe)]<SUB>N</SUB>/FeMn multilayers were investigated. With the help of the careful designs of layer structures, a series of samples whose surface anisotropies have the linear function N was prepared with constant bulk anisotropies. From the experimental data obtained, it was found that H<SUB>ex</SUB> does not depend on the surface anisotropy, while H<SUB>c</SUB> shows a strong dependence. Therefore, it is possible to tailor wide ranges of H<SUB>c</SUB> (300-600 Oe) without varying H<SUB>ex</SUB>(∼200 Oe) through the single control parameter stack number N.

      • KCI등재

        DROWSY BEHAVIOR DETECTION BASED ON DRIVING INFORMATION

        M. S. WANG,N. T. JEONG,K. S. KIM,S. B. CHOI,S. M. YANG,S. H. YOU,J. H. LEE,서명원 한국자동차공학회 2016 International journal of automotive technology Vol.17 No.1

        Drowsy behavior is more likely to occur in sleep-deprived drivers. Individuals’ drowsy behavior detection technology should be developed to prevent drowsiness related crashes. Driving information such as acceleration, steering angle and velocity, and physiological signals of drivers such as electroencephalogram (EEG), and eye tracking are adopted in present drowsy behavior detection technologies. However, it is difficult to measure physiological signal, and eye tracking requires complex experiment equipment. As a result, driving information is adopted for drowsy driving detection. In order to achieve this purpose, driving experiment is performed for obtaining driving information through driving simulator. Moreover, this paper investigates effects of using different input parameter combinations, which is consisted of lateral acceleration, longitudinal acceleration, and steering angles with different time window sizes (i.e. 4 s, 10 s, 20 s, 30 s, 60 s), on drowsy driving detection using random forest algorithm. 20 s-size datasets using parameter combination of accelerations in lateral and longitudinal directions, compared to the other combination cases of driving information such as steering angles combined with lateral and longitudinal acceleration, steering angles only, longitudinal acceleration only, and lateral acceleration only, is considered the most effective information for drivers’ drowsy behavior detection. Moreover, comparing to ANN algorithm, RF algorithm performs better on processing complex input data for drowsy behavior detection. The results, which reveal high accuracy 84.8 % on drowsy driving behavior detection, can be applied on condition of operating real vehicles.

      • KCI등재

        급성신우신염 환자의 항생제 사용 및 경제성에 관한 연구

        유영인,안혜원,김주휘,윤덕심,황광서 한국병원약사회 1997 병원약사회지 Vol.14 No.2

        In order to evaluate the cost of hospitalization for anti-infective therapy against acute pyelonephrites(APN), we performed a retrospective study on the therapeutic regimens for the patients(pt) diagnosed and admitted to a 600-bed teaching hospital in Korea. The regimen of each pt was compared to the published guidelines of ten areas on initiation, selection, and follow-up. All comparisons were performed with t-test and the level of significance was set at p<0.05. Among 170 APN pts treated between 1992 and 1994, 112pts(65.9%) were analyzed excluding pts with either complications, immunosuppression or age less than 18months old. 99pts(88.4%) were female with 53pts (female 47) between 21-40years old in agreement with the reports that pts with APN were predominantly female younger than 50y.o. Therapeutic regimen in 45pts(40.2%) was completely in agreement with all ten areas of the guidelines, 66pts (58.9%) in more than 9 areas and 96pts(85.7%) in more than 8 areas. Frequently ignored areas were usage of aminoglycosides(65.1%), antibiotic therapy duration(27.6%), and transition to an appropriate oral antibiotic agent(22.9%). Most interestingly, pt's hospital stay was extened significantly by 1.2days (20%, p<0.05), when any area of guidelines was not observed. Therefore, violation of guidelines raised the cost of all the drugs by 32.9%(11.9%/day), and that of antibiotic, by 38.6%(16.6%/day). Inclusion of the admixture service fee of \748 IM or \904 for IV blunted the differeneces. Our analysis clearly shows that the appropriate antibiotic use suitable to criteria reduced cost of treating APN including hospitalization period. Furthermore, since the total cost of the therapy is dependent on that of the labor others, rising rapidly in the developing countries, a further evaluation is required for the successful pharmaceutical care.

      • KCI등재

        Solid-state synthesis and thermoelectric properties of Bi-doped Mg<sub>2</sub>Si compounds

        You, S.W.,Kim, I.H. Elsevier 2011 Current Applied Physics Vol.11 No.3

        Bi-doped Mg<SUB>2</SUB>Si (Mg<SUB>2</SUB>Si:Bi<SUB>m</SUB>, m = 0, 0.005, 0.01, 0.02, 0.03) was prepared by solid-state synthesis. The electronic transport properties (Hall coefficient, mobility and carrier concentration) and thermoelectric properties (Seebeck coefficient, electrical conductivity, thermal conductivity and figure-of-merit) were examined. Mg<SUB>2</SUB>Si was synthesized successfully by a solid-state reaction at 673 K for 6 h and Bi-doped Mg<SUB>2</SUB>Si powders were obtained by mechanical alloying for 24 h. They were fully consolidated by hot pressing at 1073 K for 1 h. All the Mg<SUB>2</SUB>Si:Bi<SUB>m</SUB> samples exhibited an n-type conduction, indicating that the electrical conduction is mainly due to electrons. The electrical conductivity increased significantly and the absolute value of the Seebeck coefficient decreased with increasing Bi content because the electron concentration was increased considerably from 10<SUP>16</SUP> to 10<SUP>20</SUP> cm<SUP>-3</SUP> by Bi doping. The thermal conductivity was not changed significantly by Bi doping due to the much larger contribution of lattice thermal conductivity over electronic thermal conductivity. The thermal conduction in Bi-doped Mg<SUB>2</SUB>Si was attributed dominantly to the lattice vibrations (phonons). A maximum thermoelectric figure-of-merit of 0.7 was obtained for Mg<SUB>2</SUB>Si:Bi<SUB>0.02</SUB> at 823 K.

      • KCI등재
      • Gibberellin-producing Serratia nematodiphila PEJ1011 ameliorates low temperature stress in Capsicum annuum L.

        Kang, S.M.,Khan, A.L.,Waqas, M.,You, Y.H.,Hamayun, M.,Joo, G.J.,Shahzad, R.,Choi, K.S.,Lee, I.J. Gauthier-Villars ; Elsevier Science Ltd 2015 European journal of soil biology Vol.68 No.-

        We studied the effects of plant growth-promoting rhizobacteria (PGPR) on the physio-hormonal attributes of pepper (Capsicum annuum L.) plants grown under low-temperature stress. After initial screening for growth promoting effect on gibberellin (GA) mutant Waito-C rice seeds, the PGPRs were analysed for gibberellins (GA) production through advanced chromatographic and spectroscopic techniques. Among 17 bacterial isolates, a novel isolate PEJ1011 produced bioactive GA<SUB>4</SUB> (8.65 ng ml<SUP>-1</SUP>) and physiologically inactive GA<SUB>20</SUB> (6.21 ng ml<SUP>-1</SUP>) and GA<SUB>9</SUB> (1.64 ng ml<SUP>-1</SUP>). The isolate PEJ1011 was identified as Serratia nematodiphila PEJ1011 using molecular techniques. To further assess it growth promoting effects, S. nematodiphila PEJ1011 was inoculated to pepper plant, where it significantly improved the growth attributes of pepper plants, while mitigated the deleterious effects of low temperature on pepper exposed to low temperature stress of 5 <SUP>o</SUP>C. It was observed that the inoculated plants grown under normal and low temperature stress contained higher endogenous GA<SUB>4</SUB> contents. To modulate cold stress, the beneficial association of PGPR up-regulated the endogenous ABA levels in pepper plants, while reduced the endogenous jasmonic acid and salicylic acid contents. This up and down regulation of stress hormones contribute to the immediate adaptation of plants exposed to low temperature stress. Current study showed the significance of S. nematodiphila PEJ1011 association to crops grown under adverse climatic conditions, and also reports the GA producing capacity of genus Serratia for the first time.

      • Phase equilibria, dissociation enthalpies, and Raman spectroscopic analyses of N<sub>2</sub> + tetra-n-butyl ammonium chloride (TBAC) semiclathrates

        Kim, S.,Baek, I.H.,You, J.K.,Seo, Y. Elsevier Scientific Pub. Co 2016 Fluid phase equilibria Vol.413 No.-

        <P>The thermodynamic phase behaviors, dissociation enthalpies, and Raman spectra of N-2 tetra-n-butyl ammonium chloride (TBAC) + water systems were measured in order to investigate the enclathration of N-2 in TBAC semiclathrates. The three-phase(H-L-W-V) equilibria of the N-2 + TBAC (1.0, 3.3, and 5.0 mol%) semiclathrates measured using a high pressure vessel as well as a high pressure micro-differential scanning calorimeter (HP mu-DSC) indicated that the N-2 TBAC semiclathrates have significant stability in the thermodynamic equilibrium compared with the N-2 gas hydrate and that they also exhibit maximum thermodynamic stability at 3.3 mol%, which corresponds to the stoichiometric concentration of TBAC center dot 29.7H(2)O. The dissociation enthalpies of the N-2 TBAC semiclathrates were determined from the endothermic dissociation thermograms of a HP mu-DSC under pressure. The Raman spectroscopic results clearly demonstrated that N-2 molecules are enclathrated in the cages of the TBAC semiclathrate. From the overall experimental results, TBAC is expected to be an effective semiclathrate former that can reduce the equilibrium dissociation pressure or enhance the equilibrium dissociation temperature for enclosing N-2 molecules as a guest in the vacant cages of TBAC semiclathrates. (C) 2015 Elsevier B.V. All rights reserved.</P>

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