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Akio Tsuneda,Yoshito Nagashima,Takahiro Inoue 대한전자공학회 2007 ITC-CSCC :International Technical Conference on Ci Vol.2007 No.7
Simple block cipher systems based on nonlinear feedback shift registers are proposed. By numerical simulations, we investigate their basic performance, such as sensitivity to keys/plaintexts and immunity against the well-known differential/linear cryptanalysis.
Characteristics and usefulness of transabdominal ultrasonography in immune-mediated colitis
Kensuke Sakurai,Takehiko Katsurada,Mutsumi Nishida,Satomi Omotehara,Shinya Fukushima,Shinsuke Otagiri,Kazunori Nagashima,Reizo Onishi,Ryo Takagi,Yoshito Komatsu,Sakamoto Naoya 대한장연구학회 2023 Intestinal Research Vol.21 No.1
Background/Aims: The usefulness of ultrasonography (US) in diseases of the gastrointestinal tract has been reported recently. This prospective study aimed to determine the features of US findings in immune-mediated colitis (IMC), an adverse event induced by immune checkpoint inhibitor, and examine the correlation between US findings, colonoscopy (CS) findings, and severity of colitis. Methods: We studied patients examined using CS and US upon suspicion of IMC in Hokkaido University Hospital between April 2018 and February 2021. Endoscopic findings of IMC were assessed using the Ulcerative Colitis Endoscopic Index of Severity (UCEIS). The severity of US findings in IMC was evaluated using US grade, which is the ultrasonographic grading scale in ulcerative colitis. Bowel wall thickness and the intensity of the color Doppler signal were also analyzed. Severity of colitis was evaluated using Common Terminology Criteria for Adverse Events (CTCAE) grade version 5. Results: Fourteen patients with IMC were enrolled. The US findings were bowel wall thickening, loss of stratification, ulceration and increased blood flow signal. The US grade was moderately correlated with the UCEIS (r=0.687, P=0.009) and CTCAE grade (r=0.628, P=0.035). Bowel wall thickness and UCEIS (r=0.628, P=0.020), as well as color Doppler signal grade and CTCAE grade (r=0.724, P=0.008), were significantly correlated. Conclusions: US findings in IMC were mainly similar to those of ulcerative colitis, but there were some findings that were characteristic only of IMC. Significant correlation was found between US findings, CS findings, and severity of colitis. Hence, US could be useful for the evaluation of IMC.