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RISS 인기검색어
- 검색키워드
- 저자 : Mutsumi Nishida (검색결과 2 건)
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Characteristics and usefulness of transabdominal ultrasonography in immune-mediated colitis
Kensuke Sakurai,Takehiko Katsurada,Mutsumi Nishida,Satomi Omotehara,Shinya Fukushima,Shinsuke Otagiri,Kazunori Nagashima,Reizo Onishi,Ryo Takagi,Yoshito Komatsu,Sakamoto Naoya 대한장연구학회 2023 Intestinal Research Vol.21 No.1
Background/Aims: The usefulness of ultrasonography (US) in diseases of the gastrointestinal tract has been reported recently. This prospective study aimed to determine the features of US findings in immune-mediated colitis (IMC), an adverse event induced by immune checkpoint inhibitor, and examine the correlation between US findings, colonoscopy (CS) findings, and severity of colitis. Methods: We studied patients examined using CS and US upon suspicion of IMC in Hokkaido University Hospital between April 2018 and February 2021. Endoscopic findings of IMC were assessed using the Ulcerative Colitis Endoscopic Index of Severity (UCEIS). The severity of US findings in IMC was evaluated using US grade, which is the ultrasonographic grading scale in ulcerative colitis. Bowel wall thickness and the intensity of the color Doppler signal were also analyzed. Severity of colitis was evaluated using Common Terminology Criteria for Adverse Events (CTCAE) grade version 5. Results: Fourteen patients with IMC were enrolled. The US findings were bowel wall thickening, loss of stratification, ulceration and increased blood flow signal. The US grade was moderately correlated with the UCEIS (r=0.687, P=0.009) and CTCAE grade (r=0.628, P=0.035). Bowel wall thickness and UCEIS (r=0.628, P=0.020), as well as color Doppler signal grade and CTCAE grade (r=0.724, P=0.008), were significantly correlated. Conclusions: US findings in IMC were mainly similar to those of ulcerative colitis, but there were some findings that were characteristic only of IMC. Significant correlation was found between US findings, CS findings, and severity of colitis. Hence, US could be useful for the evaluation of IMC.
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Effectiveness of transabdominal ultrasonography in predicting clinical relapse of Crohn’s disease
Shinya Fukushima,Takehiko Katsurada,Mutsumi Nishida,Satomi Omotehara,Kensuke Sakurai,Kana Yamanashi,Reizo Onishi,Naoya Sakamoto 대한장연구학회 2024 Intestinal Research Vol.22 No.1
Background/Aims: Transabdominal ultrasonography (US) helps evaluate Crohn’s disease (CD) activity. We investigated whether the US could predict subsequent adverse outcomes for patients with CD in clinical remission.Methods: This single-center retrospective study included patients with CD in clinical remission who underwent US between April 2011 and April 2021, focusing on the predictability of subsequent adverse outcomes within 5 years. We used the US-CD, which was calculated using multiple US findings. Predictive variables were assessed using Cox proportional hazards regression analysis, and the predictive value was evaluated using receiver operating characteristic curves.Results: Seventy-three patients were included. During a median follow-up of 1,441 days (range, 41–1,825 days), 16.4% (12/73) experienced clinical relapse, 9.6% (7/73) required endoscopic balloon dilation (EBD), 58.9% (43/73) required enhanced treatment, and 20.5% (15/73) underwent surgery. In the multivariate analysis, US-CD was significantly associated with clinical relapse (<i>P</i>= 0.038) and the need for enhanced treatment (<i>P</i>= 0.005). The area under the receiver operating characteristic curve for predicting clinical relapse and the need for EBD was 0.77 and 0.81, respectively, with US-CD (cutoff value = 11), and that for requiring enhanced treatment was 0.74 with US-CD (cutoff value = 6). Patients with US-CD ≥ 11 demonstrated a significantly higher occurrence of clinical relapse (<i>P</i>= 0.001) and EBD (<i>P</i>= 0.002) within 5 years. Patients with US-CD ≥ 6 experienced a significantly higher likelihood of requiring enhanced treatment (<i>P</i>< 0.001) within 5 years.Conclusions: High US-CD is associated with subsequent adverse outcomes in patients with CD.
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