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Kinoshita, Yoshihiro,Chen, Junwen,Rapee, Ronald M.,Bö,gels, Susan,Schneier, Franklin R.,Choy, Yujuan,Kwon, Jung-Hye,Liu, Xinghua,Schramm, Elisabeth,Chavira, Denise A.,Nakano, Yumi,Watanabe, Norio Lippincott Williams Wilkins, Inc. 2008 Journal of nervous and mental disease Vol.196 No.4
Conviction subtype Taijin-Kyofu (c-TK) is a subgroup of mental disorder characterized by conviction and strong fear of offending others in social situations. Although the concept of c-TK overlaps with that of social anxiety disorder (SAD), patients with c-TK often may not be diagnosed as such within the current Diagnostic and Statistical Manual of Mental Disorders (DSM)-IV criteria. We propose the Nagoya-Osaka criteria to amend this situation. This study examined the cross-cultural interrater reliability of the proposed criteria. Eighteen case vignettes of patients with a variety of complaints focused around social anxieties were collected from 6 different countries, and diagnosed by 13 independent raters from various nationalities according to the original DSM-IV and the expanded criteria. The average agreement ratio for the most frequent diagnostic category in each case was 61.5% with DSM-IV and 87.6% with the modified DSM-IV with Nagoya-Osaka criteria (p < 0.001). These findings indicate that the Nagoya-Osaka criteria for SAD can improve interrater reliability of SAD.
Persistent activation of Nrf2 through p62 in hepatocellular carcinoma cells
Inami, Yoshihiro,Waguri, Satoshi,Sakamoto, Ayako,Kouno, Tsuguka,Nakada, Kazuto,Hino, Okio,Watanabe, Sumio,Ando, Jin,Iwadate, Manabu,Yamamoto, Masayuki,Lee, Myung-Shik,Tanaka, Keiji,Komatsu, Masaaki The Rockefeller University Press 2011 The Journal of cell biology Vol.193 No.2
<P>Suppression of autophagy is always accompanied by marked accumulation of p62, a selective autophagy substrate. Because p62 interacts with the Nrf2-binding site on Keap1, which is a Cullin 3–based ubiquitin ligase adapter protein, autophagy deficiency causes competitive inhibition of the Nrf2–Keap1 interaction, resulting in stabilization of Nrf2 followed by transcriptional activation of Nrf2 target genes. Herein, we show that liver-specific autophagy-deficient mice harbor adenomas linked to both the formation of p62- and Keap1-positive cellular aggregates and induction of Nrf2 targets. Importantly, similar aggregates were identified in more than 25% of human hepatocellular carcinomas (HCC), and induction of Nrf2 target genes was recognized in most of these tumors. Gene targeting of <I>p62</I> in an HCC cell line markedly abrogates the anchorage-independent growth, whereas forced expression of p62, but not a Keap1 interaction-defective mutant, resulted in recovery of the growth defect. These results indicate the involvement of persistent activation of Nrf2 through the accumulation of p62 in hepatoma development.</P>
Effects of Ultrasonic Peening on Fatigue Strength of Out-of-plane Gusset Joints
Koji Kinoshita,Akito Imamura,Yoshihiro Watanabe,Mitsuru Handa 한국강구조학회 2014 International Journal of Steel Structures Vol.14 No.4
Effect of high frequency peening treatment with a small radius tip pin, which is less than 3mm radius tip pin, still remainsunclear, although the effect of ultrasonic impact treatment on fatigue strength has been investigated. The objective of this studyis to investigate the effect of ultrasonic peening with a 1.5mm radius tip pin on fatigue strength of out-of-plane gusset weldedjoints. Plate bending fatigue tests of those joints carried out. The results show that the peening can improve fatigue strength,when mean stress does not change or already changes before the peening is carried out. It also shows that the effect of theultrasonic impact peening become less with increasing mean stress after the ultrasonic peening was carried out, and when theultrasonic peening is not sufficient for the weld toe.
이은송,Mohammad Musharraf Uddin Bhuiyan,Hiroyuki Watanabe,Kohji Matsuoka,Yoshihiro Fujise,Hajime Ishikawa,Yutaka Fukui 대한수의학회 2009 JOURNAL OF VETERINARY SCIENCE Vol.10 No.4
In this study, we examined the feasibility of using subzonal cell injection with electrofusion for interspecies somatic cell nuclear transfer (iSCNT) to produce sei whale embryos and to improve their developmental capacity by investigating the effect of osmolarity and macromolecules in the culture medium on the in vitro developmental capacity. Hybrid embryos produced by the electrofusion of fetal whale fibroblasts with enucleated porcine oocytes were cultured in modified porcine zygote medium-3 to examine the effects of osmolarity and fetal serum on their in vitro developmental capacity. More than 66% of the whale somatic cells successfully fused with the porcine oocytes following electrofusion. A portion (60∼81%) of the iSCNT whale embryos developed to the two- to four-cell stages, but no embryos were able to reach the blastocyst stage. This developmental arrest was not overcome by increasing the osmolarity of the medium to 360 mOsm or by the addition of fetal bovine or fetal whale serum. Our results demonstrate that sei whale-porcine hybrid embryos may be produced by SCNT using subzonal injection and electrofusion. The pig oocytes partly supported the remodeling and reprogramming of the sei whale somatic cell nuclei, but they were unable to support the development of iSCNT whale embryos to the blastocyst stage.
Vapor-Phase Ethylation of Biphenyl over MTW Zeolites
Mulla, Shafeek Abdul Rashid,Waghmode, Suresh B.,Watanabe, Seiji,Maekawa, Hiroyoshi,Komura, Kenichi,Kubota, Yoshihiro,Sugi, Yoshihiro,Kim, Jong-Ho,Seo, Gon The Chemical Society of Japan 2006 Bulletin of the Chemical Society of Japan Vol.79 No.9
<P>Vapor-phase ethylation of biphenyl (BP) with ethanol over the MTW zeolites was examined by using a fixed-bed flow reactor, and compared to the catalyses over MOR and MFI zeolites. Two types of MTW zeolites: MTW-S (small crystal) and MTW-L (large crystal) were synthesized under hydrothermal conditions. The selectivity for 4,4′-diethylbiphenyl (4,4′-DEBP) over the MTW zeolites was the highest among the other zeolites, such as MOR and MFI. The catalytic activity of MTW-S was higher than MTW-L. The selectivities for 4,4′-DEBP at 300 °C were ca. 30% for MTW-S and ca. 22% for MTW-L among the DEBP isomers. The dealumination of the MTW zeolites enhanced the selectivity for 4,4′-DEBP although the catalytic activity was slightly decreased. In particular, the selectivity for 4,4′-DEBP over dealuminated MTW-L by steaming and subsequent refluxing in hydrochloric acid increased from 22 to 42% at 300 °C. The enhancement of the selectivity for 4,4′-DEBP is due to the decrease in non-selective reactions at external acid sites because these sites are removed by the dealumination. The selectivities are higher than those of equilibrium mixtures, and the slimmest isomer. 4,4′-DEBP is preferentially formed due to the steric interaction of reactants and products with acidic sites in the MTW channels. Molecular modeling on the diffusion of products in the MTW channel suggests that 4,4′-DEBP isomer can diffuse most easily among DEBP isomers. 4,4′-DEBP and other isomers easily diffuse inside MOR channel; however, they cannot in the MFI channels. These results show that the formation of 4,4′-DEBP is the most favorable due to the diffusion and the restriction of transition state in the MTW channels.</P>