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RISS 인기검색어
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- 저자 : Yoonsun Chung (검색결과 24 건)
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Chung, Kwangzoo,Han, Youngyih,Kim, Jinsung,Ahn, Sung Hwan,Ju, Sang Gyu,Jung, Sang Hoon,Chung, Yoonsun,Cho, Sungkoo,Jo, Kwanghyun,Shin, Eun Hyuk,Hong, Chae-Seon,Shin, Jung Suk,Park, Seyjoon,Kim, Dae-Hy The Korean Society for Radiation Oncology 2015 Radiation Oncology Journal Vol.33 No.4
Purpose: The purpose of this report is to describe the proton therapy system at Samsung Medical Center (SMC-PTS) including the proton beam generator, irradiation system, patient positioning system, patient position verification system, respiratory gating system, and operating and safety control system, and review the current status of the SMC-PTS. Materials and Methods: The SMC-PTS has a cyclotron (230 MeV) and two treatment rooms: one treatment room is equipped with a multi-purpose nozzle and the other treatment room is equipped with a dedicated pencil beam scanning nozzle. The proton beam generator including the cyclotron and the energy selection system can lower the energy of protons down to 70 MeV from the maximum 230 MeV. Results: The multi-purpose nozzle can deliver both wobbling proton beam and active scanning proton beam, and a multi-leaf collimator has been installed in the downstream of the nozzle. The dedicated scanning nozzle can deliver active scanning proton beam with a helium gas filled pipe minimizing unnecessary interactions with the air in the beam path. The equipment was provided by Sumitomo Heavy Industries Ltd., RayStation from RaySearch Laboratories AB is the selected treatment planning system, and data management will be handled by the MOSAIQ system from Elekta AB. Conclusion: The SMC-PTS located in Seoul, Korea, is scheduled to begin treating cancer patients in 2015.
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Clinical implementation of Dosimetry Check™ for TomoTherapy <sup>®</sup> delivery quality assurance
Chung, Eunah,Kwon, Dongyeol,Park, Taeyang,Kang, Hyeri,Chung, Yoonsun unknown 2018 Journal of applied clinical medical physics Vol.19 No.6
<P><B>Abstract</B></P><P><B>Purpose</B></P><P>The delivery quality assurance (DQA) of intensity‐modulated radiotherapy (IMRT) plans is a prerequisite for ensuring patient treatments. This work investigated the clinical usefulness of a new DQA system, Dosimetry Check™(DC), on TomoTherapy<SUP>®</SUP>‐based helical IMRT plans.</P><P><B>Methods</B></P><P>The DQA was performed for 15 different TomoTherapy<SUP>®</SUP>‐based clinical treatment plans. In Tomotherapy<SUP>®</SUP> machines, the couch position was set to a height of 400 mm and the treatment plans were delivered using QA‐Treatment mode. For each treatment plan, the plan data and measured beam fluence were transferred to a DC‐installed computer. Then, DC reconstructed the three‐dimensional (3D) dose distribution to the CT images of the patient. The reconstructed dose distribution was compared with that of the original plan in terms of absolute dose, two‐dimensional (2D) planes and 3D volume. The DQA results were compared with those performed by a conventional method using the cheese phantom with ion chamber and radiochromic film.</P><P><B>Results</B></P><P>For 14 out of the 15 treatment plans, the absolute dose difference between the measurement and calculation was less than 3% and the gamma pass rate with the 3%/3 mm gamma evaluation criteria was greater than 95% for both DQA methods. The <I>P</I>‐value calculated using Wilcoxon signed‐rank test was 0.256, which implies no statistically significance in determining the absolute dose difference between the two methods. For one treatment plan generated using the 5.0 cm field width, the absolute dose difference was greater than 3% and the gamma pass rate was less than 95% with DC, while the DQA result with the cheese phantom method passed our TomoTherapy<SUP>®</SUP> DQA tolerance.</P><P><B>Conclusion</B></P><P>We have clinically implemented DC for the DQA of TomoTherapy<SUP>®</SUP>‐based helical IMRT treatment plans. DC carried out the accurate DQA results as performed with the conventional cheese phantom method. This new DQA system provided more information in verifying the dose delivery to patients, while simplifying the DQA process.</P>
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Development of Program for Relative Biological Effectiveness (RBE) Analysis of Particle Beam Therapy
Chung, Yoonsun,Ahn, Sang Hee,Choi, Changhoon,Park, Sohee Korean Society of Medical Physics 2017 의학물리 Vol.28 No.1
Relative biological effectiveness (RBE) of particle beam needs to be evaluated at particle beam therapy centers before the clinical application of the particle beam. However, since RBE analysis is implemented manually, it is useful to have a tool that can easily and effectively handle the data of experiments to generate cell survival curve and to analyze RBE simultaneously. In this work, the development of a program for RBE analysis of particle beam therapy was presented. This RBE analysis program was developed to include two parts; fitting the cell survival curves to linear-quadratic model and calculating the RBE values at a certain endpoint using fitting results. This program was also developed to simultaneously compare and analyze the template results that stored experiment data with photon and particle beam irradiations. The results of the cell survival curve obtained by each irradiation can be analyzed by the user on a desired data after reading the template stored in the easy-to-use excel file. The analysis results include the cell survival curves with error range, which are appeared in the screen and the ${\alpha}$ and ${\beta}$ parameters of linear-quadratic model with 95% confidence intervals, RBE values, and $R^2$ values to evaluate goodness-of-fit of survival curves to model, which are stored in a text cvs file. This software can generate cell survival curve, fit to model, and calculate RBE all at once with raw experiment data, so it helps users to save time for data handling and to reduce the possibility of making error on analysis. As a coming plan, we will create a user-friendly graphical user interface to present the results more intuitively.
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The first private-hospital based proton therapy center in Korea
Kwangzoo Chung,Youngyih Han,Jinsung Kim,Sung Hwan Ahn,Sang Gyu Ju,Sang Hoon Jung,Yoonsun Chung,Sungkoo Cho,Kwanghyun Jo,Eun Hyuk Shin,Chae-Seon Hong,Jung Suk Shin,Seyjoon Park,Dae-Hyun Kim,Hye Young K 대한방사선종양학회 2015 Radiation Oncology Journal Vol.33 No.4
Purpose: The purpose of this report is to describe the proton therapy system at Samsung Medical Center (SMC-PTS) including the proton beam generator, irradiation system, patient positioning system, patient position verification system, respiratory gating system, and operating and safety control system, and review the current status of the SMC-PTS. Materials and Methods: The SMC-PTS has a cyclotron (230 MeV) and two treatment rooms: one treatment room is equipped with a multi-purpose nozzle and the other treatment room is equipped with a dedicated pencil beam scanning nozzle. The proton beam generator including the cyclotron and the energy selection system can lower the energy of protons down to 70 MeV from the maximum 230 MeV. Results: The multi-purpose nozzle can deliver both wobbling proton beam and active scanning proton beam, and a multi-leaf collimator has been installed in the downstream of the nozzle. The dedicated scanning nozzle can deliver active scanning proton beam with a helium gas filled pipe minimizing unnecessary interactions with the air in the beam path. The equipment was provided by Sumitomo Heavy Industries Ltd., RayStation from RaySearch Laboratories AB is the selected treatment planning system, and data management will be handled by the MOSAIQ system from Elekta AB. Conclusion: The SMC-PTS located in Seoul, Korea, is scheduled to begin treating cancer patients in 2015.
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가동헌,Lim Chung-Man,Jang Yoonsun,Son Tae Il,Han Dong Keun,정윤기 한국조직공학과 재생의학회 2022 조직공학과 재생의학 Vol.19 No.1
Background To prevent unsolved problems of medical devices, we hypothesized that combinatorial effects of zwitterionic functional group and anti-bacterial metal ions can reduce effectively the thrombosis and bacterial infection of polymeric biomaterials. In this research, we designed a novel series of zwitterionic polyurethane (zPU) additives to impart anti-thrombotic properties to a polyvinyl chloride (PVC) matrix. Methods We have synthesized zPUs by combination of various components and zPUs complexed with metal ions. Zwitterion group was prepared by reaction with 1,3-propane sultone and Nmethyldiethanolamine and metal ions were incorporated into sulfobetaine chains via molecular complexation. These zPU additives were characterized using FT-IR, 1H-NMR, elemental analysis, and thermal analysis. The PVC film blended with zPU additives were prepared by utilizing a solvent casting and hot melting process. Results Water contact angle demonstrated that the introduction of zwitterion group has improved hydrophilicity of polyurethanes dramatically. Protein adsorption test resulted in improved anti-fouling effects dependent on additive concentration and decreases in their effects by metal complexation. Platelet adhesion test revealed anti-fouling effects by additive blending but not significant as compared to protein resistance results. Conclusion With further studies, the synthesized zPUs and zPUs complexed with metal ions are expected to be used as good biomaterials in biomedical fields. Based on our results, we can carefully estimate that the enhanced anti-fouling effect contributed to reduced platelet adhesion.
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구체축열복사냉난방시스템과 외기전담공조시스템의 통합 적용에 따른 냉방성능 평가
이윤선(Lee, YoonSun),이겨레(Lee, Keo-Re),정웅준(Chung, Woong June),임재한(Lim, Jae-Han) 대한건축학회 2018 대한건축학회 학술발표대회 논문집 Vol.38 No.1
In order to decrease energy consumption of heating and cooling in building, Thermally Activated Building System(TABS) is provided due to energy efficient performance and reduction of peak load. The purpose of this study was to evaluate the cooling performance of TABS with Dedicated Outdoor Air system(DOAS) in Korea climate. DOAS coupled with a parallel sensible cooling could be promising because TABS handles sensible heat load only. Compared to Air Handling Unit system(AHU), DOAS allows for 22.3% more use of cooling performance of TABS. The integration of DOAS and TABS increases the potential for building energy saving.
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국내 여름철 기후조건에서 DOAS와 TABS 통합시스템 냉방운전시 실내온열환경 및 운전특성 평가
이윤선(Lee, YoonSun),이겨레(Lee, Keo-Re),정웅준(Chung, Woong June),임재한(Lim, Jae-Han) 대한건축학회 2018 대한건축학회논문집 Vol.34 No.11
To reduce the energy consumption of HVAC system in buildings, thermally activated building system(TABS) has been applied to low energy building because of energy efficient performance and reduction of peak load. DOAS coupled with a parallel sensible cooling could be promising because TABS handles sensible heat load only. The purpose of this study was to evaluate the indoor thermal environment and cooling operation characteristic of TABS with dedicated outdoor air system(DOAS) in Korea climate. Indoor thermal environment and operation characteristic of TABS integrated with DOAS are investigated at different TABS operation schedules and climate conditions by simulation tests. The result shows that the DOAS is more suitable for hot and humid climates. And also it show that the potential of intermittent operation of TABS.
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