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( Chang Taek Oh ),( Do Hyun Lee ),( Kyo Tan Koo ),( Jay Lee ),( Ho Sang Yoon ),( Yoo Mi Choi ),( Tae Rin Kwon ),( Beom Joon Kim ) 대한피부과학회 2014 Annals of Dermatology Vol.26 No.6
Background: Over the last decade, the incidence of ultraviolet B (UVB)-related skin problems has increased. Oxidative stress caused by UVB induces the secretion of melanocyte growth and activating factors from keratinocytes, which results in the formation of cutaneous hyperpigmentation. Therefore, increasing the antioxidant abilities of skin cells is thought to be a beneficial strategy for the development of sunscreen agents. Superoxide dismutase 1 (SOD1) is an antioxidant enzyme that is known to exhibit antioxidant properties. Objective: The purpose of this study was to investigate the effect of SOD1 on alpha-melanocyte stimulating hormone (α-MSH) and UVB-induced melanogenesis in B16F10 melanoma cells and HRM-2 melanin-possessing hairless mice. Methods: The inhibitory effect of SOD1 on tyrosinase activity was evaluated in a cell-free system. Additional experiments were performed using B16F10 melanoma cells to demonstrate the effects of SOD1 in vitro, and HRM-2 melanin-possessing hairless mice were used to evaluate the antimelanogenic effects of SOD1 in vivo. Results: We found that SOD1 inhibited melanin production in a dose-dependent manner without causing cytotoxicity in B16F10 melanoma cells. SOD1 did not inhibit tyrosinase activity under cell-free conditions. The results indicate that SOD1 may reduce pigmentation by an indirect, nonenzymatic mechanism. We also found that SOD1 decreased UVB-induced melanogenesis in HRM-2 melanin-possessing hairless mice, as visualized through hematoxylin and eosin staining and Fontana-Masson staining. Conclusion: Our results indicate that SOD1 has an inhibitory effect on α-MSH and UVB-induced melanogenesis, indicating that SOD1 may be a promising sunscreen agent. (Ann Dermatol 26(6) 681∼687, 2014)
( Yeon Wook Kim ),( Hye-rin Kang ),( Byoung Soo Kwon ),( Sung Yoon Lim ),( Yeon Joo Lee ),( Jong Sun Park ),( Young- Jae Cho ),( Ho Il Yoon ),( Jae Ho Lee ),( Choon-taek Lee ) 대한결핵 및 호흡기학회 2019 대한결핵 및 호흡기학회 추계학술대회 초록집 Vol.127 No.0
Purpose: Although lung cancer screening using lowdose computerized tomography (LDCT) has become a standard of care for heavy smokers, the potential benefits and harms of LDCT screening in never-smokers remains unclear. The aim of this study was to determine the prevalence of nodules considered for invasive biopsy, and evaluate the final diagnosis and complications related to procedures in never-smokers who undergo LDCT screening. Method: This retrospective cohort study evaluated 37,436 adults who received LDCT screening for lung cancer between January 2009 and December 2018 at a tertiary center in South Korea. Data were collected on cases of nodule detection, follow-ups, diagnostic procedures, and clinical outcomes, and analyzed according to smoking history. Result: Of the 17,968 never-smokers, 2,908 (16.2%) were detected with positive nodules during the study period, of which 51.2% had ground-glass nodules. 139 (0.77%) subjects received invasive biopsy for pathologic diagnosis, and 84 (0.47%) were diagnosed with lung cancer. Among the subjects who underwent invasive diagnosis, 50 (36.0%) were diagnosed benign, with a significant proportion of mycobacterial disease. 20 (14.4%) experienced procedure-related complication, with no case of death. Among 84 lung cancer patients, 82 (97.6%) had adenocarcinomas, and 75 (89.3%) presented with stage I disease, resulting in favorable treatment outcomes. Conclusion: LDCT screening in never-smokers resulted in a significant detection rate of lung nodules which led to invasive biopsy. The complication rates, false-positive rates, and lung cancer detection rates were fairly comparable to ever-smokers. Accordingly, benefits and harms of LDCT screening in never-smokers, especially in Asian population, should be actively discussed.
( Sung Woo Park ),( Ae Rin Baek ),( Do Jin Kim ),( An Soo Jang ),( Soo Taek Uh ),( Yong Hoon Kim ),( Choon Sik Park ),( Yoon Pyo Kang ),( Sung Won Kwon ) 대한결핵 및 호흡기학회 2014 대한결핵 및 호흡기학회 추계학술대회 초록집 Vol.118 No.-
Background: Idiopathic pulmonary fibrosis (IPF) is characterized chronic progressive lung fibrosis with poor prognosis. Many part of pathogenesis of IPF is still not known. Metabolomics is the study of molecules created by cellular metabolic pathways. we hypothesize that exploring the metabolic pathways of lung tissues from IPF could revealing a clear pathogenesis of IPF Methods: Lung tissues obtained from 12 patients with IPF and from 12 normal subjects and performed global metabolomic profiling using gas chromatography coupled to mass spectrometry. Results: Through unsupervised principal component analysis (PCA), the variation and outlier of samples were monitored and the clustering patterns between IPF and control groups were confirmed. Based on this, we performed a supervised method, partial least squares discriminant analysis (PLS-DA), to establish the predictive and discriminative models. To interpret the data more reliably, the metabolites selected by PLS-DA and univariate statistical analyses due to the value of area under the receiver operator characteristic curve (AUROC) more than 0.9, were proved to have high prediction performance between the groups. The expression patterns of the identified metabolites indicated an anaerobic glycolysis, depletion of ATP, impairment of glutathione biosynthesis, and increase of ornithine-proline metabolism as distinctive metabolic phenotypes of IPF. Conclusions: Our enhanced metabolomics approach verified the existing hypotheses of pathogenesis in IPF at the metabolite level and suggested noteworthy signals of pathogenic metabolites related to IPF.
( Sung Woo Park ),( Ae Rin Baek ),( Do Jin Kim ),( An Soo Jang ),( Soo Taek Uh ),( Y Ong Hoon Kim ),( Choon Sik Park ),( Yoon Pyo Kang ),( Sung Won Kwon ) 대한내과학회 2014 대한내과학회 추계학술대회 Vol.2014 No.1
Background: Idiopathic pulmonary fi brosis (IPF) is characterized chronic progressive lung fi brosis with poor prognosis. Many part of pathogenesis of IPF is still not known. Metabolomics is the study of molecules created by cellular metabolic pathways. we hypothesize that exploring the metabolic pathways of lung tissues from IPF could revealing a clear pathogenesis of IPF Methods: Lung tissues obtained from 12 patients with IPF and from 12 normal subjectsand performed global metabolomic profi ling using gas chromatography coupled to mass spectrometry. Results: Through unsupervised principal component analysis (PCA), the variation and outlier of samples were monitored and the clustering patterns between IPF and control groups were confi rmed. Based on this, we performed a supervised method, partial least squares discriminant analysis (PLS-DA), to establish the predictive and discriminative models. To interpret the data more reliably, the metabolites selected by PLS-DA and univariate statistical analyses due to the value of area under the receiver operator characteristic curve (AUROC) more than 0.9, were proved to have high prediction performance between the groups. The expression patterns of the identifi ed metabolites indicated an anaerobic glycolysis, depletion of ATP, impairment of glutathione biosynthesis, and increase of ornithine-proline metabolism as distinctive metabolic phenotypes of IPF. Conclusions: Our enhanced metabolomics approach verifi ed the existing hypotheses of pathogenesis in IPF at the metabolite level and suggested noteworthy signals of pathogenic metabolites related to IPF.
최득철,방몽숙,윤택림,Cui De-Zhe,Vang Mong-Sook,Yoon Taek-Rin 대한치과보철학회 2006 대한치과보철학회지 Vol.44 No.2
Statement of problem: Ti-alloy has been used widely since it was produced in the United States in 1947 because it has high biocompatibility and anticorrosive characteristics. Purpose: The pure titanium, however, was used limitedly due to insufficient mechanical charateristics and difficult manufacturing process. Our previous study was focused on the development of a new titanium alloy. In the previous study we found that the Ti-Ta-Nb alloy had better mechanical characteristics and similar anticorrosive characteristics to Ti-6Al-4V Material and methods: In this study, the cytotoxicity of the Ti-Ta-Nb alloy was evaluated by MTT assay using MSCs(Mesenchaimal stem cells) and L929 cells(fibroblast cell line). The biocompatibility of the Ti-Ta-Nb alloy was performed by inserting the alloy into the femur of the rabbits and observing the radiological and histological changes surrounding the alloy implant. Results: 1. In the cytotoxicity test using MSCs, the 60% survival rate was observed in pure titanium, 84% in Ti-6Al-4V alloy and 95% in Ti-10Ta-10Nb alloy. 2. In the animal study, the serial follow-up of the radiographs showed no separation or migration revealing gradual bone ingrowth surrounding the implants. Similar radiographic results were obtained among three implant groups pure titanium, Ti-6Al-4V alloy and Ti-10Ta-10Nb alloy. 3. In the histologic examination of the bone block containing the implants. the bone ingrowth was prominent around the implants with the lapse of time. There was no signs of any tissue rejection, degeneration, or inflammation. Active bone ingrowth was observed around the implants. In the comparison of the three groups, the rate of bone ingrowth was better in the Ti-10Ta-10Nb alloy group than those in pure titanium group or Ti-6Al-4V alloy group. In conclusion, Ti-10Ta-10Nb alloy revealed better biocompatibility in survival rate of the cells and bone ingrowth around the implants. Therefore we believe a newly developed Ti-10Ta-10Nb alloy can replace currently used Ti-6Al-4V alloy to increase biocompatibility and to decrease side effects. Conclusion: In conclusion, Ti-10Ta-10Nb alloy revealed better biocompatibility in survival rate of the cells and bone ingrowth around the implants. Therefore we believe a newly developed Ti-10Ta-10Nb alloy can replace currently used Ti-6Al-4V alloy to increase biocompatibility and to decrease side effects.