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조진석,윤관섭,박순식,나정열,석등우 한양대학교 이학기술연구소 2003 이학기술연구지 Vol.6 No.-
음파를 이용한 해저면 분류를 위하여 2003년 5월 19-25일까지 남해해역에서 음향 실험을 실시하였다. 실험 해역은 해저 구성물질이 각기 다른 6개의정점을 선정하였으며 5개의 주파수(30,50,80,100,12 kHz)를 이용하여 해저면 반사 신호를 측정하였다. 또한 피스톤 코어를 이용하여 해저 퇴적물의 입도분석을 실시하였다. 해저면의 분류를 위해서는 펴지 이론(fuzzy logic)을 사용하였으먀, 이때의 입력 소속함수(input membership function)는 주파수 종속성을 갖는 해저면 반사손실 모텔(HYBRL, Hanyang University Bottom Reflection Loss)이 이용되었으며 출력 소속함수(out membership function)는 해저면의 평균입도 값으로 출력되도록 구성하였다. 퍼지이론을 통해 역산된 평균입도(mean grain size)와 코어 분석 자료를 비교하여 퍼지이론을 이용한 해저면 분류 방법의 가능성을 확인하였다. Acoustic experiments are performed for seafloor classificaton from 19 May to 25 May 2003. The six differnet sites of bottom composition are settled and the bottom reflecton losses with frequencies(30, 50, 80,100,120 kHZ) are measured. The fuzzy logic is used to classify the seabed. In the fuzzy olgic, HYBRL(HanYang Univ. Bottom Refleciton Loss) of frequency dependence is used as a input Membership functions and the output membership functions are composed of the values of the mean grain size of the bottom. The possibility of the seafloor classsification is verified comparing the inversed mean grain size using fuzzy logic with the results of the coring.
박순식,최지웅,윤관섭,나정열 한양대학교 이학기술연구소 2002 이학기술연구지 Vol.5 No.-
During the last several decades, although there have been lots of efforts to develope the high-frequency bottom reflection loss model, the frequency dependence of bottom loss was not considered in most cases because the sea bottom was assumed to be generally much smoother and lower gradient than the sea surface. However, if the sea bottom is rougher than acoustic wavelength, the scattered field will be increased and the reflected field will be decreased. In this paper, the high-frequency bottom reflection losses were obtained through the measurement of reflected waves from the artificially-made-flat sandy bottom. The experimental data were compared with the values calculated by the forward loss model of Mourad & Jackson. Conseouently, we suggest the frequency dependence of bottom reflection loss. 기존 해저면 반사손실 모델들은 해저면을 해수면에 비해 거칠기와 경사도가 매우 평탄하거나 완만한 경계면으로 가정하므로 주파수에 따른변화를 고려하지 않거나 미약하다고 가정하였다. 그러나 고주파를 사용하는 소오나 시스템의 경우, 음파의 파장에 비해 해저면이 거칠다면 음파는 산란 영향이 증가하게 되므로 상대적으로 반사손실 또한 증가하게 된다. 따라서 본 논문에서는 임의로 모의된 사질 성분의 해저면에서 수십 ㎑ 이상의 고주파들을 사용하여 주파수별 반사손실을 계산하고, 이를 기존의 해저면 반사손실 모델과 비교하였으며, 해저면 반사손실의 주파수 종속성을 제시하고자 한다.
신극선,탁관철,윤정섭 大韓成形外科學會 1993 Archives of Plastic Surgery Vol.20 No.1
Eighty-three consesutive free-flap transfers were reviewed to analyze distribution of type of reconsturctions, kinds of donor flaps as well incidence of complications. The role of emergent exploration and the effect of preoperative wound conditions in flap survival were evaluate. Free flap transfer for head and neck reconstruciton was most common as 46 cases, followed by for upper extremity of 22cases, for lower extremity 12 cases and for trunk & breast 3 cases. Two patients exhibited within 7 days after the operation because of respiratory complications. Eight flaps exhibited signs of circulatory insufficiency between 5 hours and 7 days. three were managed conservatively with ultimate partial necrosis of the flaps. Five flaps required return to the operating room. On exploration, early arterial occlusion was revealed in 1 flap, late arterial occlusion in 2 flaps, late venous occlusion in 1 flap and hematoma in 1 flap. The average time from the first abnormal examination to exploration was 2.4 hours. There were no false-positive explorations. Two free flaps in which abonormal findings were first noticed 4 days and 7 days after microsurgical transfer respectively failed in spite of the correction of the cause of circulatory compromise. The remaining 3 flaps were salvaged following the correction of the cause. Recipient vessel problems such as irradiation and infection were the most common cause of circulatory crisis. Among the five flaps requiring return to the operating room. single vein was anastomosed in four flaps and two veins in the remaining one. In the totally failed two flaps only songle vein was anastomosed. The results of this study demonstrate the efficacy of clinical monitoring and the role of early exploration. Precautious selection of recipient vessels and two vein anastomosis are recommended for safe and better prognosis.
Yoon, Jhin-Yeong,Lee, Jeong Seob,Yoon, Seung Soo,Kim, Young Kwan Korean Chemical Society 2014 Bulletin of the Korean Chemical Society Vol.35 No.6
Two red emitters, 2-(7-(4-(diphenylamino)styryl)-2-methyl-4H-chromen-4-ylidene)malonitrile (Red 1) and 2-(7-(julolidylvinyl)-2-methyl-4H-chromen-4-ylidene)malonitrile (Red 2) have been designed and synthesized for application as red-light emitters in organic light emitting diodes (OLEDs). In these red emitters, the julolidine and triphenyl moieties were introduced to the emitting core as electron donors, and the chrome-derived electron accepting groups such as 2-methyl-(4H-chromen-4-ylidene)malononitrile were connected to electron donating moieties by vinyl groups. To explore the electroluminescence properties of these materials, multilayered OLEDs using red materials (Red 1 and Red 2) as dopants in $Alq_3$ host were fabricated. In particular, a device using Red 1 as the dopant material showed maximum luminous efficiencies and power efficiencies of 0.82 cd/A and 0.33 lm/W at $20mA/cm^2$. Also, a device using Red 2 as a dopant material presented the CIEx,y coordinates of (0.67, 0.32) at 7.0 V.
Yoon Dahye,Choi Bo-Ram,Shin Woo Cheol,Kim Kwan-Woo,Lee Young-Seob,Lee Dae Young 한국응용생명화학회 2023 Applied Biological Chemistry (Appl Biol Chem) Vol.66 No.-
Studies on the use of natural products to treat cancer are ongoing, and turmeric (Curcuma longa L.), a medicinal crop, is known for various effects including anticancer activity. In this study, the inhibitory effect of C. longa and demethoxycurcumin on cancer cell growth in a colorectal cancer cell line (HCT116) was investigated by using nuclear magnetic resonance (NMR) spectroscopy-based metabolomics. For this analysis, HCT116 cells were treated with doxorubicin (positive control), C. longa extract, or demethoxycurcumin (20, 40, and 60 μM). In the NMR spectra of the HCT116 cell extract, 45 metabolites were identified and quantified. The quantified metabolites were analyzed by biomarker analysis, and significantly changed metabolites were filtered by the area under the curve (AUC) of the receiver operator characteristic (ROC) curve. Multivariate statistical analysis of NMR spectra was conducted to confirm the distribution among groups. Through an S-line plot, it was possible to identify metabolites that contributed to the differences seen in the OPLS-DA score plot. Taken together, the results reveal that C. longa extract induces oxidative stress and changes the energy metabolism in HCT116 cells, and that demethoxycurcumin inhibits the energy metabolism strategy for the survival of cancer cells, escape from immune cells, and cancer cell proliferation, thereby enabling the survival of HCT116 cells.
( Yoon Seob Kim ),( Kwan Ho Jeong ),( Young Jun Woo ),( Hong Jin Joo ),( Jung Eun Kim ),( Beom Joon Kim ),( Hoon Kang ) 대한피부과학회 2015 대한피부과학회 학술발표대회집 Vol.67 No.2
Background: Microneedle treatment is a method that creates transdermal microchannels across the stratum corneum barrier layer of skin. Wound-induced hair follicle regeneration via the Wnt/モ-catenin signaling pathway following wounding in adult mice was demonstrated. No previous study showed a therapeutic effect of microneedle on hair growth by wounding. Objectives: We aimed to investigate the effect of repeated microwound formed by microneedle treatment on hair growth and hair-growth-related genes in a murine model. Methods: A disk-type microneedle roller was applied to each group of mice five times a week for three weeks. First, to identify the optimal length and cycle, microneedles of lengths of 0.15, 0.25, 0.5, and 1 mm and cycles of 3, 6, 10, and 13 cycles were applied. Second, the effect of hair growth and hair-growth-related genes such as Wnt3a, モ-catenin, VEGF, and Wnt10b was observed using optimized microneedle. Outcomes were observedusing visual inspection, real-time polymerase chain reaction, and immunohistochemistry. Results: We found that the optimal length and cycle of microneedle treatment on hair growth was 0.25 mm/10 cycle and 0.5mm/10 cycle. Repeated microneedle stimulation promoted hair growth, and it also induced the enhanced expression of Wnt3a, モ-catenin, VEGF, and Wnt10b. Conclusion: Our study provides evidence that microneedle stimulation can induce hair growth via activation of a wound healing process that includes the Wnt/モ-catenin pathway and VEGF.