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Hong Gil-Sun,Jang Miso,Kyung Sunggu,Cho Kyungjin,Jeong Jiheon,Lee Grace Yoojin,Shin Keewon,Kim Ki Duk,Ryu Seung Min,Seo Joon Beom,Lee Sang Min,Kim Namkug 대한영상의학회 2023 Korean Journal of Radiology Vol.24 No.11
Artificial intelligence (AI) in radiology is a rapidly developing field with several prospective clinical studies demonstrating its benefits in clinical practice. In 2022, the Korean Society of Radiology held a forum to discuss the challenges and drawbacks in AI development and implementation. Various barriers hinder the successful application and widespread adoption of AI in radiology, such as limited annotated data, data privacy and security, data heterogeneity, imbalanced data, model interpretability, overfitting, and integration with clinical workflows. In this review, some of the various possible solutions to these challenges are presented and discussed; these include training with longitudinal and multimodal datasets, dense training with multitask learning and multimodal learning, self-supervised contrastive learning, various image modifications and syntheses using generative models, explainable AI, causal learning, federated learning with large data models, and digital twins.
한국 농장동물 수의사의 항생제 신중사용에 대한 인식과 실천
Yoojin Choi,Seola Joo,Sang-Won Lee,Hong-Jae Lee,Myung-Sun Chun 대한수의학회 2023 大韓獸醫學會誌 Vol.63 No.2
Antimicrobial (AM) resistance is a growing threat in human and veterinary medicine, spreading across species and perceived as One-Health issue. Prudent use of AM products is essential in mitigating this risk in both human and veterinary medicine. Farm veterinarians, responsible for prescribing appropriate AM and offering advice to farmers on their proper usage, are regarded as key players in the livestock industry. An online survey of farm veterinarians (n = 1,531) was conducted to assess their educational experience, beliefs, current status of prescription, practical behavior, and self-efficacy regarding the prudent use of antimicrobials (PUA). The data from 170 respondents were analyzed using descriptive statistics, regression and mediation analysis. Participants chose AM based on their experiences, academic resources, and peer veterinarians. Approximately 77% did not routinely conduct antibiotic-susceptibility-test. Most participants believed in the importance of PUA and the role of veterinarians to reduce AM resistance, but they reported a lack of awareness among farmers and insufficient national support interfere with their practical behavior with regard to PUA. Half of the participants had PUA-education, and 78.6% reported that education had a positive impact on their behavior with PUA. Self-efficacy partly mediates the relationship between belief and behavior for PUA, which accounted for 23.77% of the total effect that beliefs have on behavior for PUA. The findings of the study show that enhancing veterinarians’ abilities to practice and their self-efficacy through education tailored to the current status of farms can contribute to the reduction of AMs in the livestock sector.
A case of uterine prolapse during pregnancy
( Jiyun Hong ),( Yoojin Na ),( Kicheol Kil ) 대한산부인과학회 2020 대한산부인과학회 학술대회 Vol.106 No.-
Prolapse uteri during pregnancy is a rare event. We demonstrate a case of a patient with uterine prolapse during pregnancy. The patient was treated with vaginal pessary to avoid maternal and fetal risks, which would be fatal. We removed the pessary at 36+5wks of gestation and the patient delivered vaginally after pessary was removed. At postpartum follow-up uterine prolapse recurred and vaginal pessary was reinserted.
Stem Cell-Derived Extracellular Vesicles as Immunomodulatory Therapeutics
Seo, Yoojin,Kim, Hyung-Sik,Hong, In-Sun Hindawi 2019 Stem cells international Vol.2019 No.-
<P>Mesenchymal stem cells (MSCs) have been reported to possess regulatory functions on immune cells which make them alternative therapeutics for the treatment of inflammatory and autoimmune diseases. The interaction between MSCs and immune cells through paracrine factors might be crucial for these immunomodulatory effects of MSCs. Extracellular vesicles (EVs) are defined as bilayer membrane structures including exosomes and microvesicles which contain bioactive paracrine molecules affecting the characteristics of target cells. Recently, several studies have revealed that EVs derived from MSCs (MSC-EVs) can reproduce similar therapeutic impacts of parent MSCs; MSC-EVs could regulate proliferation, maturation, polarization, and migration of various immune effector cells and modulate the immune microenvironment depending on the context by delivering inflammatory cytokines, transcription factors, and microRNAs. Therefore, MSC-EVs can be applied as novel and promising tools for the treatment of immune-related disorders to overcome the limitations of conventional cell therapy regarding efficacy and toxicity issues. In this review, we will discuss current insights regarding the major outcomes in the evaluation of MSC-EV function against inflammatory disease models, as well as immune cells.</P>
불안정 애착과 관계중독의 관계: 자기통제력에 의해 조절된 내면화된 수치심의 매개효과
홍세림 ( Hong Serim ),장유진 ( Jang Yoojin ) 한국청소년학회 2023 청소년학연구 Vol.30 No.5
본 연구에서는 성인들의 불안정 애착과 관계중독의 관계에서 내면화된 수치심의 매개효과를 확인하고, 이러한 매개효과가 자기통제력 수준에 따라 변화하는지 확인하고자 하였다. 전국 20대~50대 성인 307명을 대상으로 자기 보고식 설문을 통해 자료를 수집하였고 수집된 자료는 SPSS 26.0과 PROCESS Macro를 활용하여 분석하였다. 주요한 연구결과를 요약하면 다음과 같다. 첫째, 애착불안이 높을수록 관계중독 수준이 높은 것으로 나타났으며, 애착회피는 관계중독과 유의한 관련성을 보이지 않았다. 둘째, 애착불안과 관계중독의 관계에서 내면화된 수치심이 부분 매개하는 것으로 나타났다. 셋째, 내면화된 수치심과 관계중독의 관계에서 자기통제력의 조절효과가 유의하였다. 넷째, 애착불안이 내면화된 수치심을 거쳐 관계중독에 미치는 간접효과가 자기통제력의 수준에 따라 달라지는 것으로 나타나 조절된 매개효과가 유의하였다. 연구 결과를 바탕으로 청소년 상담에서의 시사점을 제시하였으며, 연구의 제한점을 토대로 후속연구의 방향을 제언하였다. This study examined the mediating effects of internalized shame between insecure attachment and relation addiction among adults and whether these mediating effects would vary depending on levels of self-control. Data were collected using the self-report survey from 307 adults aged between their 20s to 50s. The collected data were analyzed using SPSS 26.0 and PROCESS Macro. The main results are as follows. First, an anxious attachment was positively related to relationship addiction, but the avoidant attachment was not significantly correlated with relationship addiction. Second, internalized shame partially mediated the relationship between anxious attachment and relationship addiction. Third, self-control moderated the relationship between internalized shame and relationship addiction. Fourth, the indirect effect of anxious attachment on relationship addiction via internalized shame varied depending on levels of self-control, indicating that the moderated mediation effect was significant. Based on the findings, implications for counseling adolescents were presented, as well as directions for future studies along with the limitations of this study.
Chronic Epstein-Barr virus infection causing both benign and malignant lymphoproliferative disorders
Kwun, Yoojin,Hong, Soo-Jong,Lee, Jin Seong,Son, Da Hye,Seo, Jong Jin The Korean Pediatric Society 2014 Clinical and Experimental Pediatrics (CEP) Vol.57 No.9
The Epstein-Barr virus (EBV) is oncogenic and can transform B cells from a benign to a malignant phenotype. EBV infection is also associated with lymphoid interstitial pneumonia (LIP). Here, we report the case of a 14-year-old boy who was diagnosed with a latent EBV infection and underlying LIP, without any associated immunodeficiency. He had been EBV-seropositive for 8 years. The first clinical presentations were chronic respiratory symptoms and recurrent pneumonia. The symptoms worsened in the following 2 years. The results of in situ hybridization were positive for EBV, which led to a diagnosis of LIP. The diagnosis was confirmed by the results of a thoracoscopic lung biopsy. The EBV titer of the bronchoalveolar lavage specimens obtained after acyclovir treatment was found to be fluctuating. The patient had latent EBV infection for 8 years, until presented at the hospital with intermittent abdominal pain and distension. Physical examination and pelvic computed tomography revealed a large mesenteric mass. A biopsy of the excised mass led to a diagnosis of Burkitt's lymphoma (BL). The patient received combination chemotherapy for 4 months, consisting of vincristine, methotrexate, cyclophosphamide, doxorubicin, and prednisolone. He is now tumor-free, with the LIP under control, and is being followed-up at the outpatient clinic. This is the first report of a Korean case of chronic latent EBV infection that developed into LIP and BL in a nonimmunocompromised child.