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Zhang, Hua,Tong, Jinjin,Zhang, Yonghong,Xiong, Benhai,Jiang, Linshu Asian Australasian Association of Animal Productio 2020 Animal Bioscience Vol.33 No.1
Objective: In the present study, an liquid chromatography/mass spectrometry (LC/MS) metabolomics approach was performed to investigate potential biomarkers of milk production in high- and low-milk-yield dairy cows and to establish correlations among rumen fluid metabolites. Methods: Sixteen lactating dairy cows with similar parity and days in milk were divided into high-yield (HY) and low-yield (LY) groups based on milk yield. On day 21, rumen fluid metabolites were quantified applying LC/MS. Results: The principal component analysis and orthogonal correction partial least squares discriminant analysis showed significantly separated clusters of the ruminal metabolite profiles of HY and LY groups. Compared with HY group, a total of 24 ruminal metabolites were significantly greater in LY group, such as 3-hydroxyanthranilic acid, carboxylic acids, carboxylic acid derivatives (L-isoleucine, L-valine, L-tyrosine, etc.), diazines (uracil, thymine, cytosine), and palmitic acid, while the concentrations of 30 metabolites were dramatically decreased in LY group compared to HY group, included gentisic acid, caprylic acid, and myristic acid. The metabolite enrichment analysis indicated that protein digestion and absorption, ABC transporters and unsaturated fatty acid biosynthesis were significantly different between the two groups. Correlation analysis between the ruminal microbiome and metabolites revealed that certain typical metabolites were exceedingly associated with definite ruminal bacteria; Firmicutes, Actinobacteria, and Synergistetes phyla were highly correlated with most metabolites. Conclusion: These findings revealed that the ruminal metabolite profiles were significantly different between HY and LY groups, and these results may provide novel insights to evaluate biomarkers for a better feed digestion and may reveal the potential mechanism underlying the difference in milk yield in dairy cows.
Zhang Yifan,Shen Jinhuang,Ma Xinhua,Yao Mingshuang,Zhang Yonghong,Cao Dairong 한국응용생명화학회 2022 Applied Biological Chemistry (Appl Biol Chem) Vol.65 No.3
Acanthus ilicifolius var. xiamenensis (Acanthaceae), a mangrove found in southeastern China, is an herb with strong antiinflammatory property. Phytochemical study of the mangrove showed that the plant has a high content of phenylethanol glycoside acteoside (AC). In this research, the anti-inflammatory activity of acteoside on dextran sodium sulphate (DSS)-mediated mouse ulcerative colitis model were studied. For DSS- mediated colitis in mice, AC can reduce weight loss and DAI score in UC mice, suppress colon shortening and alleviate colon pathological injury. Moreover, AC treatment notably up-regulates IL-10, down-regulates the levels of IL-1β and TNF-α, and inhibits the protein expression of JAK2/STAT3, NF-κB p65, IKKα/β and IKB of colon. In addition, after AC treatment, the level of MDA and NO in colonic tissue were remarkably decreased, while the levels of GSH, SOD, and Nrf2 and HO-1 protein expression levels were significantly increased. These results indicate that AC can activate the Nrf2 signaling pathway by inhibiting the JAK/STAT, iNOS/eNOS and NF-κB signaling cascades, enhance the intestinal barrier function, and effectively reduce DSS-induced UC in mice.
Tiantian Zhang,Xuejiao Cui,Jincheng Zhang,Hui Wang,Meng Wu,Hua Zeng,Yuanyuan Cao,Jingze Liu,Yonghong Hu 대한기생충학열대의학회 2015 The Korean Journal of Parasitology Vol.53 No.6
In order to explore tick proteins as potential targets for further developing vaccine against ticks, the total proteins of unfed female Dermacentor silvarum were screened with anti-D. silvarum serum produced from rabbits. The results of western blot showed that 3 antigenic proteins of about 100, 68, and 52 kDa were detected by polyclonal antibodies, which means that they probably have immunogenicity. Then, unfed female tick proteins were separated by 12% SDS-PAGE, and target proteins (100, 68, and 52 kDa) were cut and analyzed by LC-MS/MS, respectively. The comparative results of peptide sequences showed that they might be vitellogenin (Vg), heat shock protein 60 (Hsp60), and fructose-1, 6-bisphosphate aldolase (FBA), respectively. These data will lay the foundation for the further validation of antigenic proteins to prevent infestation and diseases transmitted by D. silvarum.
Anti-Inflammatory Activity of Phenylethanoids from Acanthus ilicifolius var. xiamenensis
Yifan Zhang,Jinhuang Shen,Xinhua Ma,Yubin He,Yonghong Zhang,Dairong Cao 한국식품영양과학회 2023 Journal of medicinal food Vol.26 No.2
Acanthus ilicifolius var. xiamenensis is a traditional herbal medicine in China. In this study, the anti-inflammatory activities of active ingredients of A. ilicifolius var. xiamenensis were investigated in RAW 264.7 cells and Freund's complete adjuvant-induced arthritic rats. Results showed that n-butanol extract exerted antiarthritic potential by reducing paw edema, arthritis score, and altered hematological and biochemical parameters in experimental rats. Phytochemical studies on n-butanol extract resulted in the isolation of five alkaloids (1–5) and five phenylethanoids (6–10). The anti-inflammatory assay of compounds 1–10 on lipopolysaccharide (LPS)-treated RAW 264.7 cells indicated that phenylethanoids 9 and 10 exhibited notable inhibitory activities. The result indicated that compounds 9 and 10 attenuated inflammation by decreasing the production of nuclear factor kappa-B (NF-κB) p65, inhibitory subunit of NF kappa B alpha, Janus kinase 2 (JAK2), signal transducer and activator of transcription 3 (STAT3), and inducible nitric oxide synthase in LPS-mediated RAW 264.7 macrophages. Phenylethanoids 9 and 10 increased the expression of interleukin-10 and endothelial nitric oxide synthase. Therefore, compounds 9 and 10 showed anti-inflammatory activity by regulation of NF-κB and JAK/STAT signaling pathways.
Yonghong Peng,Shuai Zhang,Fanghua Zhu,Wa Li,Yong Yi,Kai Du,Qiang Yin 성균관대학교(자연과학캠퍼스) 성균나노과학기술원 2018 NANO Vol.13 No.7
There is a demand for composite films with excellent hydrophobic properties in inertial confinement fusion (ICF) physics experiments. In this paper, we prepared fluorinated polyimide hydrophobic films using spinning and plasma etching methods. The experimental results indicate that the water contact angle for the perfluorodecyltrichlorosilane (PFTS) treatment polyimide (PI) film is 112.0°, which is larger than the pure PI film (69°). The rap oil contact angle is 84.2°, which is also much larger than the contact angle of PI film (12°). Moreover, the surface roughness of the prepared films was measured by white light interferometry (WLI). The surface roughness (Ra) of pure PI is 9.79 nm, but with the application of FSiO2 particles, the Ra of the films increases to 65.05 nm. After plasma treatment, the Ra of the PI/FSiO2 composite film increases to 186.71 nm because plasma treatment can scratch the film surface and increase its roughness. However, treating the PI/FSiO2 composite film with the plasma and PFTS, the Ra is only 88.90 nm. This decrease in Ra is due to the PFTS, which is able to reduce the surface roughness. The development of composite films, compared to pure PI films, could prove to be an extremely valuable material in ICF experiments.
Biomimetic Total Synthesis of Paeoveitol
Zhang, Yuhan,Guo, Yonghong,Li, Zhongle,Xie, Zhixiang American Chemical Society 2016 ORGANIC LETTERS Vol.18 No.18
<P>A highly stereocontrolled synthesis of paeoveitol has been developed in 26% yield, in 7 steps from commercially available materials. The synthetic strategy was inspired primarily by the biogenetic hypothesis and was enabled by hetero-Diels–Alder cycloaddition to construct the target molecular framework.</P><P><B>Graphic Abstract</B> <IMG SRC='http://pubs.acs.org/appl/literatum/publisher/achs/journals/content/orlef7/2016/orlef7.2016.18.issue-18/acs.orglett.6b02228/production/images/medium/ol-2016-02228p_0009.gif'></P><P><A href='http://pubs.acs.org/doi/suppl/10.1021/ol6b02228'>ACS Electronic Supporting Info</A></P>
( Yonghong Chen ),( Jie Yang ),( Xuehong Cao ),( Shibing Zhang ) 한국인터넷정보학회 2020 KSII Transactions on Internet and Information Syst Vol.14 No.8
The Poisson point process (PPP) is widely used in wireless network modeling and performance analysis because it can provide tractable results for heterogeneous cellular networks (HetNets) analysis. However, it cannot accurately reflect the spatial distribution characteristics of the actual base stations (BSs). Considering the fact that the distribution of macro base stations (MBSs) is exclusive, the deployment of MBSs is modeled by the Matérn hard-core point process (MHCPP), and the deployment of pico base stations (PBSs) is modeled by PPP. This paper studies the performance of multiantenna HetNets and improves the energy efficiency (EE) of HetNets by optimizing the transmit power of PBSs. We use a simple approximate method to study the signal-to-interference ratio (SIR) distribution in two-tier MHCPP-PPP HetNets and derive the coverage probability, average data rate and EE of HetNets. Then, an optimization algorithm is proposed to improve the EE of HetNets. Finally, three transmission technologies are simulated and analyzed. The results show that multiantenna transmission has better system performance than single antenna transmission and that selecting the appropriate transmit power for a PBS can effectively improve the EE of the system. In addition, two-tier MHCPP-PPP HetNets have higher EE than two-tier PPP-PPP HetNets.