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Xian-Yong Lan,Chu-Zhao Lei,Yong-Tao Huai,Chuan-Ying Pan,Jing Wang,Yong-Zhen Huang,Hong Chen 한국유전학회 2011 Genes & Genomics Vol.33 No.6
Sine oculis homeobox homolog 3 (Six3) gene is responsible for normal mammalian pituitary development, and its genetic variations or deficiency will cause hypopituitarism, suggesting that this gene is a potential candidate gene for studying association with growth traits in animals. Herein, genetic variants within bovine Six3 gene was screened in 1031 individuals from four Chinese indigenous cattle breeds. Two novel polymorphisms (NC_007309:g.2515G>A and NC_007309:g.2607T>C) locating at positions nt1707 and nt1799 of intron 1 in bovine Six3gene, were found, and could be genotyped by TaqI ACRS PCR-RFLP and Alw26I PCR-RFLP, respectively. The frequencies of allele “A” of TaqI locus varied from 0.004 to 0.309,as well as the frequencies of allele “C” of Alw26I locus waved from 0.025 to 0.340. Association analysis revealed no significant association of TaqI locus with growth traits in Nanyang breed. However, significant relationships between Alw26I locus and body weight (BW) and average daily gain (ADG) in Nanyang breed was found (p<0.05). The individuals with genotype TC had greater body weight and average daily gain than those with genotype TT at 18 months old. Furthermore, based on combinated genotypes from these two loci, diplotypes was found to be associated with growth traits (p<0.05).The individuals with dihaplotype GG-TC had greater body weight and average daily gain at 18 month-old than those of other dihaplotypes. Therefore, the TaqI and Alw26I genetic variants of bovine Six3 gene were recommended as DNA markers related to growth traits through marker-assisted selection for genetics and breeding in cattle.
Huang, Hui,Zhang, Bin,Chen, Wen,Zhou, Shuang-Mei,Zhang, Yong-Xia,Gao, Li,Xu, Zhen-Gang,Qiao, You-Lin,Tang, Ping-Zhang Asian Pacific Journal of Cancer Prevention 2012 Asian Pacific journal of cancer prevention Vol.13 No.3
This study focused on infection rates and subtypes of human papillomavirus (HPV) in patients with oropharyngeal squamous cell carcinoma (OSCC), and the relationship between HPV status and prognosis of the disease. We evaluated sixty-six OSCC patients who met the enrollment criteria during the period from January 1999 to December 2009. The presence or absence of oncogenic HPV types in tumors was determined using the SPF10 LiPA25 assay. Overall survival (OS) and disease specific survival (DSS) for HPV positive and HPV negative patients were estimated using Kaplan-Meier analysis. The Cox regression model was applied for multivariate analysis. HPV-DNA was detected in 11(16.7%) of all specimens. Among them, 7 were type HPV-16, while other types were HPV-16/11, HPV-35, HPV-58/52, and HPV-33/52/54. Patients with HPV positive tumors were more likely to be female, non-smokers and non-drinkers (p=0.002, 0.001 and 0.001, respectively). After a median follow-up of 24.5 months, patients with HPV positive tumors had significantly better overall survival (HR=0.106[95%CI=0.014-0.787], p=0.016,) and disease specific survival (HR=0.121[95%CI=0.016-0.906], p=0.030). Patients with HPV positive OSCC have significantly better prognosis than patients with HPV negative tumors. HPV infection is an independent prognostic factor.
Zhen Zhang,Hui Hua Huang,Xiang Ma,Guanghui Li,Yong Wang,Guo Sun,Yinglai Teng,Rian Yan,Ning Zhang,AiJun Li 한국공업화학회 2017 Journal of Industrial and Engineering Chemistry Vol.53 No.-
A new and efficient technique is described for the production of diacylglycerols (DAGs) by the esterification of oleic acid with glycerol catalyzed by diatomite-loaded SO4 2/TiO2. DAGs show some potential health benefits compared to triacylglycerols, and also can be used to produce the novel industrial plasticizer epoxy fatty acid methyl ester in material science. Diatomite-loaded SO4 2/TiO2 catalyst was prepared and characterized, and the selected conditions for the synthesis of DAGs were determined to be: reaction time = 6.0 h, temperature = 210 C, catalyst loading = 0.1% of the oleic acid weight, and mass ratio of oleic acid to glycerol = 2:1. Under these conditions, DAGs yield reached 59.6% with a purity of 69.6% after a one-stage molecular distillation. Diatomite-loaded SO4 2/TiO2 as a solid catalyst could be recycled and reused with high catalytic efficiency. Under the same conditions, diatomite-loaded SO4 2/TiO2 showed a better catalytic performance than the commercial solid acid SO4 2/ZrO2-Al2O3. Based on this, a two-step reaction method for the production of DAGs was performed and provided a yield similar to the one-step method (58.3% vs. 59.6%), but with a shorter reaction time (4 h vs. 6 h). It is concluded that a two-step reaction method could be a better alternative to the one-step production of DAGs in the presence of diatomite-loaded SO4 2/TiO2.
Wu, Zhen-Guo,Li, Jun-Tao,Zhong, Yan-Jun,Guo, Xiao-Dong,Huang, Ling,Zhong, Ben-He,Agyeman, Daniel-Adjei,Lim, Jin-Myoung,Kim, Du-ho,Cho, Maeng-hyo,Kang, Yong-Mook American Chemical Society 2017 ACS APPLIED MATERIALS & INTERFACES Vol.9 No.25
<P>A synergistic approach for advanced cathode materials is proposed. Sodium manganese oxide with a layered-tunnel hybrid structure was designed, synthesized, and subsequently investigated. The layered-tunnel hybrid structure provides fast Na ion diffusivity and high structural stability thanks to the tunnel phase, enabling high rate capability and greatly improved cycling stability compared to that of the pure P2 layered phase while retaining the high specific capacity of the P2 layered phase. The hybrid Structure provided a decent discharge capacity of 133.4 mAh g(-1) even at 8 C, which exceeds the reported hest rate capability for Mn-based cathodes. It also displayed an impressive cycling stability, maintaining 83.3 mAh g(-1) after 700 cycles at 10 C. Theoretical calculation and the potentiostatic intermittent titration technique (PITT) demonstrated that this hybrid structure helps enhance Na ion diffusivity during charge and discharge, attaining, as a result, an unprecendented electrochemical performance.</P>
Xu, Jia-Li,Wang, Zhen-Wu,Hu, Ling-Min,Yin, Zhi-Qiang,Huang, Ming-De,Hu, Zhi-Bin,Shen, Hong-Bing,Shu, Yong-Qian Asian Pacific Journal of Cancer Prevention 2012 Asian Pacific journal of cancer prevention Vol.13 No.5
Objective: The PI3K/PTEN/AKT/mTOR signaling pathway has been implicated in resistance to cisplatin. In the current study, we determined whether common genetic variations in this pathway are associated with platinum-based chemotherapy response and clinical outcome in advanced non-small cell lung cancer (NSCLC) patients. Methods: Seven common single nucleotide polymorphisms (SNPs) in core genes of this pathway were genotyped in 199 patients and analyzed for associations with chemotherapy response, progression-free survival (PFS) and overall survival (OS). Results: Logistic regression analysis revealed an association between AKT1 rs2494752 and response to treatment. Patients carrying heterozygous AG had an increased risk of disease progression after two cycles of platinum-based chemotherapy compared to those with AA genotype (Adjusted odds ratio (OR)=2.18, 95% confidence interval (CI): 1.00-4.77, which remained significant in the stratified analyses). However, log-rank test and cox regression detected no association between these polymorphisms in the PI3K pathway genes and survival in advanced NSCLC patients. Conclusions: Our findings suggest that genetic variants in the PI3K/PTEN/AKT/mTOR pathway may predict platinum-based chemotherapy response in advanced NSCLC patients in a Chinese population.