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- 저자 : Yong-Quan Li (검색결과 40 건)
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( Lijun Wei ),( Nirmal Marasini ),( Gao Li ),( Chul Soon Yong ),( Jong Oh Kim ),( Qizhe Quan ) 영남대학교 약품개발연구소 2013 영남대학교 약품개발연구소 연구업적집 Vol.23 No.0
Ligustrazine is a traditional Chinese medicine used to treat various cardiovascular and neurovascular complications. However, this compound exhibits rapid first-pass metabolism, a short biological half-life, low stability and potential vascular irritation that restrict its use for long-term therapy. The use of a lipid emulsion as a carrier for intravenous administration of ligustrazine might provide sustained and prolonged release, thereby reducing the frequency of administration and improving patient compliance. The main purpose of our study was to develop a highly stable and sterile optimal formulation of a ligustrazine lipid emulsion (LLE) and to evaluate its pharmacokinetic behavior and tissue distribution in rats. The final optimal formulation consisted of soybean oil (12.0%), oleic acid (0.6%), lecithin (1.0%), poloxamer 188 (0.6%) and glycerol (2.25%). The average particle size, polydispersity index (PDI), zeta-potential and pH of the final product were 215.0±2.5 nm, 0.076±0.033, -40.4±5.3 mV and 7.25±0.05, respectively. The LLE was stable for at least three months at room temperature. In vitro drug release studies of the LLE suggested a sustained release profile, which was further confirmed by in vivo pharmacokinetic studies in rats. The area under the drug concentration-time curve from 0 h to 10 h (AUC(0-10h)) for LLE was increased by 1.6-fold compared with that of the commercially available ligustrazine injection (LI), suggesting enhanced bioavailability from the lipid-based emulsion. Furthermore, a tissue distribution study showed significant improvement in the distribution pattern of ligustrazine with a higher AUC(0-180 min) observed in all tissues for LLE than for LI. In conclusion, LLE, with excellent stability, improved pharmacokinetics and tissue distribution, demonstrates great potential for the delivery of ligustrazine for clinical applications.ⓒ2012 Elsevier B.V.All rights reserved.
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Member capacity-based progressive collapse analysis of transmission towers under wind load
Yong-Quan Li,Yong Chen,Guohui Shen,Wenjuan Lou,Weijian Zhao,Hao Wang 한국풍공학회 2021 Wind and Structures, An International Journal (WAS Vol.33 No.4
The wind-induced collapse of transmission towers has raised many concerns. Progressive collapse analysis is recognized as a promising method for the assessment of the collapse-resistant capacity of the transmission tower. The finite element model of an actual transmission tower is firstly built for the analysis, in which the dynamic behavior of the member in failure is taken into account to be in accord with the actual tower collapse. The analysis considering the main design load cases is conducted in advance to determine the case under which the tower has the potential to collapse. The incremental dynamic analysis in association with the explicit time integration algorithm is employed to perform a progressive collapse analysis, where the wind loads are simulated by using the linear filtering method, and the developed failure criterion with axial force and bending moment involved is based on the stability bearing capacity of the members. It is found the tower collapse begins with the horizontal bracing member near the waist. Then, the adjacent members, including the leg members, fail sequentially, and the tower collapses eventually with a shear-type failure. The demand to capacity ratio (DCR) in terms of bearing capacity of the member is defined to quantify the structural behavior, the location of the member that has the potential to fail, and when the initial failure occurs are thereby identified. It is concluded that compared to the member capacity-based analysis, the ultimate strain-based analysis, which is most likely to be an inelastic dynamic analysis permitting a large deformation, may overestimate the bearing capacity of the structure in wind-induced collapse.
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Li Yong,Wu Qiong,Liu Hong-Li,Pei Nan-Cai,He Yan-Xia,Quan Jine 한국유전학회 2022 Genes & Genomics Vol.44 No.2
Background: The genetic basis of crop yield is an agricultural research hotspot. Identifying the genes related to yield traits is the key to increase the yield. Weeping forsythia is an emerging medicinal crop that currently lacks excellent varieties. The genes related to fruit yield in weeping forsythia have not been identified. Objective: Thus, we aimed to screen the candidate genes related to fruit yield of weeping forsythia by using genome-wide association analysis. Methods: Here, 60 samples from the same field and source of weeping forsythia were collected to identify its yield-related candidate genes. Association analysis was performed on the variant loci and the traits related to yield, i.e., fruit length, width, thickness, and weight. Results: Results from admixture, neighbor-joining, and kinship matrix analyses supported the non-significant genetic differentiation of these samples. Significant association was found between 2 variant loci and fruit length, 8 loci and fruit width, 24 loci and fruit thickness, and 13 loci and fruit weight. Further search on the 20 kb up/downstream of these variant loci revealed 1 gene related to fruit length, 16 genes related to fruit width, 12 genes related to fruit thickness, and 13 genes related to fruit weight. Among which, 4 genes, namely, WRKY transcription factor 35, salicylic acid-binding protein, auxin response factor 6, and alpha-mannosidase were highly related to the fruit development of weeping forsythia. Conclusion: This study identify four candidate genes related to fruit development, which will provide useful information for the subsequent molecular-assisted and genetic breeding of weeping forsythia.
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Yong-Quan Li,Chih-Hsing Liu,Wen-Qi Ruan 글로벌지식마케팅경영학회 2018 Global Marketing Conference Vol.2018 No.07
Cultural tourism has always been recognized as the heart of the new tourism trend, and Chinese culture has received increasing attention worldwide. Cultural tourism to China delivers the values of traditional Chinese culture and provides a satisfying authentic experience for tourists. Experience is an emotional reflection of tourists’ true feelings and evaluations during the tourism process and encompasses more than the delivery of a physical product or service. Experience involves creating unique memories of destinations and is inimitable of the individual sensitivity for special events. While these creative experiences have received increasing attention from marketing scholars and various industry practitioners in general product domains, the creative experience factors of tourism systems remain unexplored. Furthermore, although the matter of experience affects tourists’ behaviors and attitudes, little is known regarding how Chinese culture affects tourists’ creative experiences, destination attachments and memories. The effects of cultural contacts and creative experiences on destination attachment and roles of satisfaction and attitudes should be considered with respect to the development of cultural and creative tourism. This study proposes cultural contact as an important enabler of destination attachment. Moreover, we examine both how and when culture contacts enhance tourists’ destination attachments by considering two critical attributes as mediators, including creative experience (i.e., Escape and Recognition, Unique Involvement, Interactivity, Peace of Mind and Learning) and cultural memories. We also considered two elements of tourists’ behaviors (satisfaction and attitude) as important contingencies. We test and integrate our concepts of a moderated mediation framework using the cultural and creative tourism from a sample of 651 tourists. We discuss how our empirical results extend Chinese culture, creative experience, and destination attachment research and provide the study’s theoretical and managerial implications.
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Lim, Ju Won,Wang, Huan,Choi, Chi Hun,Quan, Li Na,Chung, Kyungwha,Park, Won-Tae,Noh, Yong-Young,Kim, Dong Ha Elsevier 2019 Journal of Power Sources Vol.438 No.-
<P><B>Abstract</B></P> <P>Developing perovskite solar cells (PSCs) with high-efficiency and a low-temperature process has great potential for the realization of the scalable, economic, and roll-to-roll based renewable energy conversion devices. ZnO has been recognized as the promising electron transport layer (ETL) that may overcome the limitations of the conventional TiO<SUB>2</SUB>. However, methylammonium lead iodide (MAPbI<SUB>3</SUB>) perovskite is prone to decomposition at the ZnO surface, which hinders the development of simple one-step deposition of perovskite, resulting in the limited photovoltaic performance. Herein, we report interlayer mediated efficient ETLs for viable flexible PSCs. The utilization of polyethyleneimine ethoxylated layer on ZnO prevents the direct contact between the perovskite and ETLs, avoiding the photoactive layer decomposition. Thus, interlayer-mediated PSCs show higher efficiency with enhanced stability by decreasing the electron transport barrier. As a result, the PSC employing tailor-designed ETL interfaces exhibited average power conversion efficiency (PCE) of 15.8%, which was superior by 25.4% to that of a control device (12.6%). With our strategy, we further demonstrated PSCs on flexible substrates which exhibit an average PCE of 11.9% under low-temperature fabrication. The new interface engineering strategy may pave the way to the realization of high performance, easy-to-process, and large-area perovskite optoelectronics.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Universal interface engineering technique for highly stable flexible PSCs. </LI> <LI> The in-depth investigation into the enhanced stability and high-efficiency PSCs. </LI> <LI> Interlayer mediated PSC exhibits 15.8% PCE, superior by 25.4% to control device. </LI> <LI> Low-temperature processed PSCs for the next-generation renewable energy sources. </LI> </UL> </P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>
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Lim, Ju Won,Wang, Huan,Choi, Chi Hun,Kwon, Hannah,Quan, Li Na,Park, Won-Tae,Noh, Yong-Young,Kim, Dong Ha Elsevier 2019 Nano energy Vol.57 No.-
<P><B>Abstract</B></P> <P>In this work, we developed the perovskite photodiodes based on the dimensionality-reduced quasi two-dimensional (Q-2D) photoactive layer structure by incorporating phenylethylammonium iodide (PEAI) into methylammonium lead iodide (MAPbI<SUB>3</SUB>), which effectively enhanced both the crystalline phase and the ambient stability of the perovskite. The Q-2D perovskite photodiode exhibited a dark current of 1.76 × 10<SUP>−7</SUP> A/cm<SUP>2</SUP>, resulting in the detectivity (D*) of 2.20 × 10<SUP>12</SUP> J and responsivity of 0.53 A/W, which is among the highest performance levels without the voltage bias (0 V) due to the systematically optimized perovskite phase resulting in the reduced leakage current. In addition, the current density of Q-2D perovskite photodiode maintained 76% of the initial level current density even after 80 days in the ambient condition, compared to 15% of 3D perovskite photodiode control sample. Such superior performance and stability were mainly attributed to the enhanced degree of crystallization of the Q-2D perovskites, which was confirmed by X-ray diffraction and grazing incidence wide-angle X-ray scattering (GIWAXS) measurement. Also, the improved stability of Q-2D perovskite films was confirmed by both lifetime test and atomic force microscopy studies where the negligible number of pinholes was observed in the quasi-2D perovskite films while considerable deformations were found in the 3D perovskites photodiode. Our study suggests a simple and robust protocol for the development of stable and high-performance perovskite photodetectors via dimensional and constitutional optimization of conventional perovskites for the practical usage of perovskite in the photodiode applications.</P> <P><B>Highlights</B></P> <P> <UL> <LI> The Q-2D perovskite photodiode exhibited the D* of 2.20 × 10<SUP>12</SUP> J and R of 0.53 A/W without the voltage bias (0 V). </LI> <LI> The current density of Q-2D perovskite photodiode maintained 76 % of the initial level while 15 % for the 3D one. </LI> <LI> Grazing incidence wide-angle X-ray scattering (GIWAXS) analysis revealed the origin of the stability improvement. </LI> <LI> Quasi-2D perovskite materials can be promising candidates for stable, tunable and flexible optoelectronic applications. </LI> </UL> </P> <P><B>Graphical abstract</B></P> <P>Dimensionality-controlled perovskite photodiodes with improved stability were systematically fabricated while retaining the comparable electrical performance of conventional three-dimensional perovskites. The quasi-2D perovskite photodetector exhibited an improved detectivity of 2.20 × 10<SUP>12</SUP> J performance and maintained 76% of initial level while the performance of three-dimensional perovskite photodetector remained only 15% after 80 days. Our study suggests a facile solution for the poor stability of the three-dimensional perovskite, with a potential for the development of highly-stable perovskite optoelectronics.</P> <P>[DISPLAY OMISSION]</P>
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PREPARATION OF CINOBUFAGIN-LOADED BOVINE SERUM ALBUMIN NANOPARTICLES FOR HEPATOCARCINOMA THERAPY
YONG-HUA SU,JIAN-GUO ZHANG,JIE SHEN,FENG-QIAN LI,HUA SU,CHANG-QUAN LING 성균관대학교(자연과학캠퍼스) 성균나노과학기술원 2009 NANO Vol.4 No.1
Cinobufagin-loaded bovine serum albumin nanoparticles were prepared for treating hepatocellular carcinoma. In this report, cinobufagin-bovine serum albumin-nanoparticles (Cino-BSA-NP) were prepared by an aqueous desolvation process. The physicochemical properties, toxicity, and cancer-related applications of Cino-BSA-NP were investigated. Cino-BSA-NP had a uniform spherical morphology with a particle size in the range of 50–240 nm and an average size of 86.3 nm. The zeta potential of the nanoparticles was -49 mV. The overall embedding ratio was 79.5% and the drug loading was 24.1%. Cino-BSA-NP gave cinobufagin release of up to 53.5% within 3 h, followed by slower controlled release. Cino-BSA-NP inhibited growth of hepatocarcinoma cells in vitro to a similar extent as free cinobufagin, but with a much higher median lethal dose (LD50). Hepatic histomorphological changes indicated that hepatic damage was much less severe with Cino-BSA-NP than with free cinobufagin (2.19 mg/kg). The survival time of nude mice with orthotopic transplantation tumors treated with Cino-BSA-NP was prolonged significantly. The results confirm that Cino-BSA-NP renders cinobufagin completely dispersible in aqueous media, meeting the key requirements for intravenous injection, and show controlled release, thus significantly improving cinobufagin's antitumor activity while reducing its side effects.
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Apoptosis Inducing Effects of 6-Methoxydihydrosanguinarine in HT29 Colon Carcinoma Cells
Yong-Jin Lee,Hu-Quan Yin,Young-Ho Kim,Guang-Yong Li,Byung-Hoon Lee 대한약학회 2004 Archives of Pharmacal Research Vol.27 No.12
6-Methoxydihydrosanguinarine (6ME), a benzophenanthridine alkaloid derived from the methanol extracts of Hylomecon hylomeconoides, showed a dose-dependent effect at 1-10 μM on causing apoptotic cell death in HT29 colon carcinoma cells (IC50 = 5.0 ± 0.2 μM). Treatment of HT-29 cells with 6ME resulted in the formation of internucleosomal DNA fragmentation. Treatment of the cells with 6ME caused activation of caspase-3, -8 and 9 protease and subsequent proteolytic cleavage of poly(ADP-ribose)polymerase. 6ME increased the expression of p53 and Bax and decreased the expression of Bid. These results indicate that p53 and proapoptotic Bcl-2 family proteins might participate in the antiproliferative activity of 6ME in HT29 cells.
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Li Jin-Yang,Du Jun-Liang,Gu Long,Zhang You-Peng,Lin Cong,Wang Yong-Quan,Zhou Xing-Chen,Lin Huan 한국원자력학회 2023 Nuclear Engineering and Technology Vol.55 No.2
The core power control is an important issue for the study of dynamic characteristics in China initiative accelerator driven subcritical system (CiADS), which has direct impact on the control strategy and safety analysis process. The CiADS is an experimental facility that is only controlled by the proton beam intensity without considering the control rods in the current engineering design stage. In order to get the optimized operation scheme with the stable and reliable features, the variation of beam intensity using the continuous and periodic control approaches has been adopted, and the change of collimator and the adjusting of duty ratio have been proposed in the power control process. Considering the neutronics and the thermal-hydraulics characteristics in CiADS, the physical model for the core power control has been established by means of the point reactor kinetics method and the lumped parameter method. Moreover, the multi-inputs single-output (MISO) logical structure for the power control process has been constructed using proportional integral derivative (PID) controller, and the meta-heuristic algorithm has been employed to obtain the global optimized parameters for the stable running mode without producing large perturbations. Finally, the verification and validation of the control method have been tested based on the reference scenarios in considering the disturbances of spallation neutron source and inlet temperature respectively, where all the numerical results reveal that the optimization method has satisfactory performance in the CiADS core power control scenarios.
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