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유국현,서용섭 東國大學校 2000 東國論叢 Vol.39 No.-
The half-life of ^54Mn is 312.2 days and main γ-energy is 835keV, therefore it is used as a standard source for a multi-channel analyzer and a dose calibrator and managanese catabolism study in human body. In this paper, a method for the production of no carrier added ^54Mn was studied via ^54Cr(p,n) and ^59Co(p, αpn), with MC-50 cyclotron and described chemical isolation method of ^54Mn from a irradiated target by ion exchange resin. Chromium and cobalt were used as target materials. The production yields of ^54Mn by 50.5 MeV protons was 4.5 μCi.μ/Ah on chromium target and 11.85 μCi/μAh on cobalt target. The cross-section and thick target yield of ^59Co(p, αpn)^54Mn reaction were measured in the energy range of 50.5→22.2MeV in order to determine the optimum conditions for the production of ^54Mn. the maximum cross-section was 47.48 mbarn at 41.2MeV.
^27Al(p,α pn)핵반응에 의한 무담체 ^22Na 제법 연구
유국현,서용섭,양승대 東國大學校 1998 東國論叢 Vol.37 No.-
A method for the production of no-carrier added(NCA) ^22Na was developed via ^27Al(p, ㄷαpn) nuclear reaction with 50.5MeV protons. the half life of ^22Na is 2.6 years and main γ-energy is 1274.5keV and it is used standard source and sodium catabolism study. The cross-section and thick target yield for the reaction was measured in detail in the energy range of 50.5→20.2MeV in order to determine the optimum conditions for the production of ^22Na. the maximum cross-section for the production of ^22Na was 40.8 mbarn at 43.85MeV. the calculated production yield of ^22Na by 50.5MeV protons on aluminium was 60.9μCi/μAh. The seperation of ^22Na was carried out by ion exchange, precipitation and diffusion. It was found that ion exchange column operation using AG50W-X4 resin was the most efficient method among them.
Kim, Hyung Suk,Park, Hansol,Park, So-Ra,Lee, Sang Hoon,Ahn, Yunho,Lee, Yong Sup,Suh, Min Chul American Chemical Society 2018 JOURNAL OF PHYSICAL CHEMISTRY C - Vol.122 No.50
<P>In this study, we showed the distortion of the central axis of the donor moiety can switch critically the rate of the reverse intersystem crossing (<I>k</I><SUB>RISC</SUB>) process, which is the trigger point to modulate the lifetime of delayed fluorescence. To achieve <I>k</I><SUB>RISC</SUB>, what we desired (10<SUP>5</SUP> to 10<SUP>6</SUP> s<SUP>-1</SUP>) in a series of donor-acceptor-donor (D-A-D) type thermally activated delayed fluorescence (TADF) materials, the donor groups (phenoxazine and phenothiazine) were selectively introduced. Maintaining the near orthogonality between donor and acceptor (benzonitrile) moiety, the occurrence of the distortion of the central axis of the donor moiety could make the effect of locally excited triplet state (<SUP>3</SUP>LE). In other words, the interaction between <SUP>3</SUP>LE and the charge transfer counterparts (i.e., <SUP>1</SUP>CT and <SUP>3</SUP>CT) contributes an opposite propensity of <I>k</I><SUB>RISC</SUB> for each of the target TADF materials when those are dissolved in solution and condensed in solid state. Herein, we have theoretically and experimentally shown the photophysical behavior of common D-A-D type TADF upon the different systems.</P> [FIG OMISSION]</BR>
Yong Jae Suh,Dae Sup Kil,Kang Sup Chung,Hyo Sook Lee,Huiping Shao 한국자기학회 2008 Journal of Magnetics Vol.13 No.3
Almost monodisperse iron oxide nanoparticles with an average particle size ranging from 5 to 43 ㎚ were fabricated using an enviro㎚entally friendly starting material, ferrous acetate. The smallest particles were formed in the presence of a reductant, 1,2-dodecanediol, while the particle size increased with increasing concentration of dispersing agents. The dispersants consisted of various combinations of oleic acid, oleylamine, trioctylphosphine, and polyvinylpyrrolidone. The threshold temperature to form crystalline particles was found to be 240 ℃. The 43 ㎚ nanoparticles exhibited a room temperature saturation magnetization and coercivity of 57 emu/g and 47 Oe, respectively.
기술정보 : 장래 기능성화장품 원료로서의 할로이사이트 활용에 관한 연구동향
서용재 ( Yong Jae Suh ),장영남 ( Young Nam Jang ),길대섭 ( Dae Sup Kil ),정강섭 ( Kang Sup Chung ),이수정 ( Su Jeong Lee ) 한국광물학회 2008 광물과 암석 (J.Miner.Soc.Korea) Vol.21 No.4
나노튜브 형상의 할로이사이트는 화장품·약물 등 활성물질의 방출시간을 연장하는데 응용할 수 있는 천연 나노광물이다. 할로이사이트를 이용한 활성물질 적재·방출 제어기술을 최초로 등록한 1997년 미국 특허를 필두로 2007년에는 비타민과 글리세린 등의 기능효과제를 광범위하게 포함하는 기능성화장품 제조기술에 대한 특허가 출원되었다. 학술 논문으로서는 화장품 보다 서방형 약물전달 기술에 관한 연구가 주로 발표되고 있다. 최근 화장품용 분체에 단순한 기재로서의 역할 뿐만 아니라 기능성을 추가로 부여하고 있다. 특히, 할로이사이트는 기능성 화장성분의 전달 속도를 제어할 수 있으며 다른 분체보다 밀도가 낮아 팩·크림·로션류의 기재로 적합하다. 따라서 나노튜브형 할로이사이트를 활용한 나노캐리어 기술은 최근 화장품 유형별 시장점유율에서 2위로 부상한 기능성화장품 분야의 핵심기술로 성장할 것으로 기대된다.
Shin, Yong-seung,Lee, Eung-goo,Shin, Gee-wook,Kim, Young-rim,Lee, Eun-young,Kim, Jae-hoon,Jang, Hwan,Gershwin, Laurel J.,Kim, Dae-yong,Kim, Yong-hwan,Kim, Gon-sup,Suh, Myung-deuk,Jung, Tae-sung WILEY-VCH Verlag 2004 Proteomics Vol.4 No.11
<P>Antigenic proteins of Neospora caninum (N. caninum) against bovine immunoglobulins M, E, A, and G were investigated by using immunoproteomics. Proteins of N. caninum (KBA-2) tachyzoite lysates separated by two-dimensional gel electrophoresis were transferred to polyvinylidene difluoride (PVDF) membranes, probed with different bovine immunoglobulin class and classified. Antigenic spots recognized were also identified by matrix-assisted laser desorption/ionization-time of flight-mass spectrometry (MALDI-TOF-MS) analysis. 132, 84, 4, and 40 antigenic protein spots were recognized on N. caninum immunoblot profiles against bovine IgM, IgE, IgA, and IgG, respectively. Of these protein spots, the antigenic proteins recognized by either IgM, IgE, and IgG, or IgM and IgG were HSP70, pyruvate kinase, actin, NCDG-1, tubulin α-chain, and putative ribosomal protein S2. On the other hand, IgM, IgE, and IgA reacted with NTPase, HSP60, tubulin β-chain, putative protein disulfide isomerase, enolase, lactate dehydrogenase, serine-threonine phosphatase, 14-3-3 protein homologue, and GRA2 protein. Most of the antigenic proteins identified were associated with the process of invasion, proliferation, and egression of apicomplexans. In our study, HSP70, actin, NTPase, HSP60, pyruvate kinase, enolase, putative ribosomal protein S2, NCDG-1, and GRA2 proteins were found to be immunodominant proteins, which may contribute to the development of diagnostic markers and vaccine.</P>
A Review on the Application of Nanotechnology in Food Processing and Packaging
Seong-In Cho,Yong-Rok Kim,Joon Woo Lee,Dae-Sup So,Yong-Jin Cho,Hyun Kwon Suh,Tu San Park,Seoung-Im Oh,Ji-Eun Im 한국산업식품공학회 2010 산업 식품공학 Vol.14 No.4
Currently, nanotechnology is widely applied in various industrial fields and is rapidly emerging as a promising future technology. In food industries, nanotechnology is used to enhance food quality and safety. Numerous cutting-edge studies on the advantages of nanotechnology have been conducted in the fields of food processing, food ingredients and additives, food packaging, and food engineering for optimal health. The market for these areas of research has grown steadily, and is expected to continue to do so. Because of this, R&D for nanotechnology that can be used effectively in food industries is being performed by several companies, as well as in academic research institutions around the world. This review describes the recent global R&D trends that have been in progress for two key areas: food processing and food packaging.
시험관내 용출 및 장관막 투과도와 생체이용률과의 상관성
서수경,손수정,박인숙,최기환,김순선,유태무,조혜영,이용복,김동섭,양지선 전남대학교 약품개발연구소 2000 약품개발연구지 Vol.9 No.1
A biopharmaceutics drug classification system for correlation between in vitro dissolution and in vivo bioavailability is proposed based on recognizing that drug dissolution and gastrointestinal permeability are the fundamental parameters controlling the rate and extent of drug absorption. The objective of this study was to assess whether in vitro dissolution projects of immediate-release beta-Mocker tablets can be correlated with intestinal membrane permeability and/or in vivo bioavailability. In vitro dissolution of the beta-Mocker tablets was examined using KP VII Apparatus II methods at various pH. Intestinal membrane permeability was determined in vitro using the diffusion chamber method. Bioavailability parameters were cited from literatures. The dissolution profiles did not accurately represent the in vivo bioavailablity. However there were good correlations between intestinal membrane permeability and log P (noctanol/buffer). The correlations obtained in this study indicted that in vitro diffusion chamber method could be used to predict intestinal absorption in vivo.
Synthesis of 1, 4-dihydropyridine derivatives with vasodilating activities (l)
Suh, Jung-Jin,Lee, Bong-Yong,Kim, Chang-Seop,Lee, Jong-Wook,Kim, Byung-Chae,Han, Byung-Hee,Kim, Choong-Sup The Pharmaceutical Society of Korea 1990 Archives of Pharmacal Research Vol.13 No.3
Asymmetric 2, 6-dimethyl-4-aryl-1, 4-dihydropyridine-3, 5-dicarboxylate with [N-(3, 4-methylenedioxybenzyl)-N-methyl] aminoethyl group as the ester moiety and related 1, 4-dihydropyridine derivatives were prepared and tested for the effects on vascular smooth muscles. 2-6-dimethyl-4-(3'-nitrophenyl)1-4-dihydropyridine-3, 5-dicarboxylic acid 3-[N-(3', 4-methylenedioxybenzyl-N-methyl] aminoethyl ester 5-methyl ester (11) and 2, 6-dimethyl-4-(3'-nitrophenyl)-1, 4-dihydropyridine-3, 5-icarboxylic acid 3-[N-2', 3'-methylenedioxybenzyl)-N-methyl] aminoethyl ester 5-ethyl ester (150 showed potent vasodilating activities $IC_{50}$($10_{-8}M$) was 2, 6 and 2.7 for 11 and 15, compared with 3.5 for nicardipine.