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Holistic Reform of the Mathematics Curriculum - the Hong Kong Exoperience
Wong, Ngai Ying,Lam, Chi Chung,Leung, Frederick Koon-Shing,Mok, Ida Ah-Chee,Wong, Ka Ming Patrick 한국수학교육학회 1999 수학교육연구 Vol.3 No.2
The Hong Kong mathematics curriculum has launched its reform in recent years. It was the first time that a holistic review of syllabi from Primary 1 through Secondary 7 was made. The curriculum development agency also decided to base the reform on sound pedagogical foundations. That was assisted with academic research where the views of various stakeholders were investigated in detail. Surveys were conducted with students, parents, teachers, employers, university professors, and curriculum designers and they give a full picture of mathematics teaching and learning in Hong Kong. The rich data collected should shed light on the development of mathematics curriculum in other regions with similar socio-cultural and educational settings.
THE IMPACT OF STATE DEVELOPMENT IN TAIWAN ON CROSS-SRAITS RELATIONS
Wong, Timothy Ka-ying The Institute for Far Eastern Studies, Kyungnam Un 1997 ASIAN PERSPECTIVE Vol.21 No.1
On September 17, 1995 the people of Hong Kong voted for the first fully elected legislature. The electoral system, introduced by the British over the prior eighteen months differed substantially from that used in the 1991 election. Both are likely to differ from that adopted by the Preparatory Committee charged with adopting the rules for electing the Hong Kong Special Administrative Region's first elected the Hong Kong Special Administrative Region's first elected legislature. The changes in the electoral system between 1991 and 1995 do not appear to have changed the overall results of the 1995 election. This paper examines the various electoral systems used in Hong Kong, the alignment of political forces, the results of the 1995 election in the context of the changes in the electoral system, and the likely effects of either a proportional representation system, the type of electoral system some have suggested for Hong Kong's future, on the legislative agenda in Hong Kong after 1997. The paper concludes that the likely changes to the electoral system after 1997 are likely to have a far greater impact on politics than the reforms implemented prior to the change of sovereignty.
Effects of coffee intake on airway hypersensitivity and immunomodulation: an in vivo murine study
Wong Ying-Chi,Hsu Wen-Cheng,Wu Tzee-Chung,Huang Ching-Feng 한국영양학회 2023 Nutrition Research and Practice Vol.17 No.4
BACKGROUND/OBJECTIVES: Coffee is a complex chemical mixture, with caffeine being the most well-known bioactive substance. The immunomodulator y and anti-inflammator y properties of coffee and caffeine impact health in various aspects, including the respirator y system. The objective is to investigate the effects of coffee and caffeine on air way hyperresponsiveness and allergic reactions, as well as to analyze and compare associated cytokine profiles. MATERIALS/METHODS: BALB/c mice were intraperitoneally sensitized with ovalbumin (OVA) and given OVA inhalation to induce air way hypersensitivity. Two weeks after sensitization, they were intragastrically gavaged with coffee or caffeine, both containing 0.3125 mg caffeine, daily for 4 weeks. Control mice were fed with double-distilled water. Serum OVA- specific antibody levels were measured beforehand and 5 weeks after the first gavage. Air way hyperresponsiveness was detected by whole body plethysmography after gavage. Cytokine levels of bronchoalveolar lavage and cultured splenocytes were analyzed. RESULTS: Coffee effectively suppressed T helper 2-mediated specific antibody response. Air way responsiveness was reduced in mice treated with either coffee or caffeine. Compared to the control, coffee significantly reduced OVA-specific immunoglobulin (Ig) G, IgG1 and IgE antibody responses (P < 0.05). Caffeine also attenuated specific IgG and IgG1 levels, though IgE level was unaffected. Coffee significantly reduced interleukin (IL)-4 and increased IL-10 concentration in spleen cells and bronchoalveolar lavage fluid (P < 0.05). CONCLUSIONS: Coffee effectively attenuated air way hyperresponsiveness and systemic allergic responses induced by OVA food allergen in mice. As a complex composition of bioactive substances, coffee displayed enhanced immunomodulator y and anti-inflammator y effects than caffeine.
Ying-Jie Chen,Jia-Ying Wu,Yu-Yi Deng,Ying Wu,Xiao-Qi Wang,Amy Sze-man Li,Lut Yi Wong,Xiuqiong Fu,Zhi-Ling Yu,Chun Liang 고려인삼학회 2022 Journal of Ginseng Research Vol.46 No.3
Sorafenib is effective in treating hepatoma, but most patients develop resistance to it. STAT3signaling has been implicated in sorafenib resistance. Artesunate (ART) and 20(R)-ginsenoside Rg3 (Rg3)have anti-hepatoma effects and can inhibit STAT3 signaling in cancer cells. This study aimed to evaluatethe effects of Rg3 in combination with ART (Rg3-plus-ART) in overcoming sorafenib resistance, and toexamine the involvement of STAT3 signaling in these effects. Methods: Sorafenib-resistant HepG2 cells (HepG2-SR) were used to evaluate the in vitro anti-hepatomaeffects of Rg3-plus-ART. A HepG2-SR hepatoma-bearing BALB/c-nu/nu mouse model was used to assessthe in vivo anti-hepatoma effects of Rg3-plus-ART. CCK-8 assays and Annexin V-FITC/PI double stainingwere used to examine cell proliferation and apoptosis, respectively. Immunoblotting was employed toexamine protein levels. ROS generation was examined by measuring DCF-DA fluorescence. Results: Rg3-plus-ART synergistically reduced viability of, and evoked apoptosis in HepG2-SR cells, andsuppressed HepG2-SR tumor growth in mice. Mechanistic studies revealed that Rg3-plus-ART inhibitedactivation/phosphorylation of Src and STAT3 in HepG2-SR cultures and tumors. The combination alsodecreased the STAT3 nuclear level and induced ROS production in HepG2-SR cultures. Furthermore, overactivation of STAT3 or removal of ROS diminished the anti-proliferative effects of Rg3-plus-ART, andremoval of ROS diminished Rg3-plus-ART's inhibitory effects on STAT3 activation in HepG2-SR cells. Conclusions: Rg3-plus-ART overcomes sorafenib resistance in experimental models, and inhibition of Src/STAT3 signaling and modulation of ROS/STAT3 signaling contribute to the underlying mechanisms. Thisstudy provides a pharmacological basis for developing Rg3-plus-ART into a novel modality for treatingsorafenib-resistant hepatoma.
Changing Students` Conceptions of Mathematics through the Introduction of Variation
( Ngai Ying Wong ),( Chit Kwong Kong ),( Chi Chung Lam ),( Ka Ming Patrick Wong ) 한국수학교육학회 2010 수학교육연구 Vol.14 No.4
Some 400 Secondary One (i.e. seventh-grade) students from 10 schools were provided with non-routine mathematical problems in their normal mathematics classes as exercises for one academic year. Their attitudes toward mathematics, their conceptions of mathematics and their problem-solving performance were measured both in the beginning and at the end of the year. Hierarchical regression analyses revealed that the introduction of an appropriate dose of non-routine problems would generate some effects on the students` conceptions of mathematics. A medium dose of non-routine problems (as reported by the teachers) would result in a change of the students` conception of mathematics to perceiving mathematics as less of "a subject of calculables." On the other hand, a high dose would lead students to perceive mathematics as more useful and more as a discipline involving thinking. However, with a low dose of non-routine problems, students found mathematics more "friendly" (free from fear). It is therefore proposed that the use of non-routine mathematical problems to an appropriate extent can induce changes in students` "lived space" of mathematics learning and broaden their conceptions of mathematics and mathematics learning.