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Acupuncture for Osteoporosis: a Review of Its Clinical and Preclinical Studies
Tian Yimiao,Wang Lili,Xu Tianshu,Li Rui,Zhu Ruyuan,Chen Beibei,Zhang Hao,Xia Bingke,Che Yiwen,Zhao Dandan,Zhang Dongwei 사단법인약침학회 2022 Journal of Acupuncture & Meridian Studies Vol.15 No.5
Acupuncture has gained growing attention in the management of osteoporosis (OP). However, a comprehensive review has not yet been conducted on the efficacy and challenges of acupuncture in preliminary research and clinical trials. Therefore, an extensive literature search was conducted using electronic databases, including PubMed (www.ncbi.nlm.nih.gov/pubmed), CNKI (www.cnki.net), and Web of Science, for studies published from the beginning of 2000 to the end of May 2022. Combinations of synonyms for OP, acupuncture, traditional Chinese medicine, clinical trial, preclinical study, and animal experiments were searched. A total of 290 papers were consulted, including 115 reviews, 109 clinical observations, and 66 preclinical studies. There is accumulating evidence to support the beneficial role of acupuncture in preserving bone quality and relieving clinical symptoms based on clinical and preclinical investigations. The top ten most commonly used acupoints are BL23, ST36, BL20, BL11, CV4, GV4, SP 6, KI3, BL18, and GB39. The underlying mechanisms behind the benefits of acupuncture may be linked with the regulation of the hypothalamic-pituitary-gonadal (adrenal) axis and activation of the Wnt/β-catenin and OPG/RANKL/RANK signaling pathways. In summary, strong evidence may still come from prospective and well-designed clinical trials to shed light on the potential role of acupuncture in preserving bone loss. Future investigations are needed to explore the potential underlying mechanisms, long-term clinical efficacy, and compliance of acupuncture in OP management.
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Stiffness effects on repeatability of positioning of linear axes
Guangming Sun,Yimiao Wang,Wenjin Wang,Jinjun Liu,Ming Yu,Jian Zhao 대한기계학회 2022 JOURNAL OF MECHANICAL SCIENCE AND TECHNOLOGY Vol.36 No.9
This paper studies the effect of stiffness (including slider stiffness and bearing stiffness) on the repeatability of the positioning of linear axes. First, a mathematical model between stiffness and the repeatability of the positioning of linear axes is established. The effects of the stiffness of the slider and bearing on the repeatability of positioning are analysed. The theoretical results show that the repeatability of the positioning decreases as the slider component stiffness and bearing stiffness increases. Second, a finite element analysis is implemented to calculate the effect of slider stiffness on the repeatability of positioning, the simulation results are found to be consistent with the theoretical results. Finally, the effect of bearing stiffness on the repeatability of positioning is experimentally investigated. The experimental and theoretical analysis results have been observed to coincide. Thus, the accuracy of the theoretical analysis is verified by both simulation and experimental results. The derived results afford designers and engineers a scientific basis for the stiffness design theory.
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