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        Effects of Water-Soluble Ganoderma lucidum Polysaccharides on the Immune Funtions of Patients with Advanced Lung Cancer

        Shufeng Zhou,Yihuai Gao,Wenbo Tang,Xihu Dai,He Gao,Guoliang Chen,Jinxian Ye,Eli Chan,Hwee Lling Koh,Xiaotian Li 한국식품영양과학회 2005 Journal of medicinal food Vol.8 No.2

        Preclinical studies have established that the polysaccharide fractions of Ganoderma lucidumhave potential an-titumor activity. Recent clinical studies have demonstrated that G. lucidumpolysaccharides enhance host immune functions[e.g., enhanced natural killer (NK) cell activity] in patients with advanced solid tumors, although an objective response wasnot observed. This open-label study aimed to evaluate the effects of water-soluble G. lucidumpolysaccharides (Ganopoly??,Encore International Corp., Auckland, New Zealand) on immune functions in patients with advanced lung cancer. Thirty-sixpatients were enrolled and treated with 5.4 g/day Ganopoly for 12 weeks. In the 30 cancer patients who completed the trial,treatment with Ganopoly did not significantly alter the mean mitogenic reactivity to phytohemagglutinin, mean counts of CD3,CD4, CD8, and CD56, mean plasma concentrations of interleukin (IL)-2, IL-6, and interferon (IFN)-., or NK activity in thepatients, but the results were significantly variable. However, some cancer patients demonstrated markedly modulated im-mune functions. The changes in IL-1 were correlated with those for IL-6, IFN-., CD3, CD8, and NK activity (P. .05), andIL-2 changes were correlated with those for IL-6, CD8, and NK activity. The results suggest that subgroups of cancer patientsmight be responsive to Ganopoly in combination with chemotherapy/radiotherapy. Further studies are needed to explore theefficacy and safety of Ganopoly used alone or in combination with chemotherapy/radiotherapy in lung cancer patients.

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        Production of biodiesel from soybean oil catalyzed by attapulgite loaded with C4H5O6KNa catalyst

        Fengxian Qiu,Bin Ye,Yihuai Li,Chuanjia Sun,Zhenyu Zhao,Teng Ma,Dongya Yang 한국화학공학회 2013 Korean Journal of Chemical Engineering Vol.30 No.7

        Biodiesel is a green, safe, renewable alternative fuel, which is of great significance to solving the problem of energy shortage and environmental pollution. A series of solid base catalysts were prepared with the support of attapulgite (ATP), the load of C4H5O6KNa by impregnation method, and were used to catalyze transesterification of soybean oil with methanol to biodiesel. The activities of prepared catalysts were investigated compared to pure ATP. The optimal conditions for the catalyst preparation were investigated: molar ratio of Na : ATP was 1.7 : 1 and calcination temperature was 400 oC. The prepared catalysts were characterized by several techniques such as Fourier transform infrared spectroscopy, scanning electron microscopy, transmission electron microscopy, N2 adsorption-desorption measurements,X-ray diffraction and the Hammett indicator method. The prepared solid base catalyst can be separated from reaction system effectively and easily. The effects of the molar ratio of methanol to oil, reaction temperature and amount of catalyst on the biodiesel yield were investigated. The experimental results showed that a 22 : 1 molar ratio of methanol to oil, 10.0% of catalyst amount, 65 oC of reaction temperature and 3.0 h of reaction time gave the best results. The catalyst has longer lifetime and maintained sustained activity after being used for five cycles.

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