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- 저자 : Yifei Guo (검색결과 5 건)
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Tianjiao Guo,Lang Chai,Yifei Guo,Lilan Tu 제어·로봇·시스템학회 2023 International Journal of Control, Automation, and Vol.21 No.7
In this paper, we construct the inter-couplings and analyze the structural controllability of interdependent networks with known directed subnets. Firstly, we divide the interdependent network into a leader-system and a follower-system. The leader-system is proved to be certainly controllable, so we focus on constructing intercouplings between two follower-subsystems and analyzing the structural controllability of the follower-system when the positions and the number of the leaders are fixed. Secondly, based on Kalman rank criterion, PBH rank criterion, as well as the graph maximum matching algorithm, combined with the controllable structure decomposition algorithm, several sufficient or necessary conditions for the structural controllability of the topological isomorphic follower-system are proposed to guarantee whether the follower-system and interdependent network are controllable or not. All the conditions provided in this paper also are suitable for the networks with undirected subnets. Finally, we take two examples to illustrate the feasibility and effectiveness of our theoretical conclusions.
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Integrated mRNA and miRNA profile expression in livers of Jinhua and Landrace pigs
Minjie Huang,Lixing Cheng,Yifei Shen,Jiucheng Chen,Xiaoling Guo,Ningying Xu 아세아·태평양축산학회 2019 Animal Bioscience Vol.32 No.10
Objective: To explore the molecular mechanisms of fat metabolism and deposition in pigs, an experiment was conducted to identify hepatic mRNAs and miRNAs expression and determine the potential interaction of them in two phenotypically extreme pig breeds. Methods: mRNA and miRNA profiling of liver from 70-day Jinhua (JH) and Landrace (LD) pigs were performed using RNA sequencing. Blood samples were taken to detect results of serum biochemistry. Bioinformatics analysis were applied to construct differentially expressed miRNA-mRNA network. Results: Serum total triiodothyronine and total thyroxine were significantly lower in Jinhua pigs, but the content of serum total cholesterol (TCH) and low-density lipoprotein cholesterol were strikingly higher. A total of 467 differentially expressed genes (DEGs) and 35 differentially expressed miRNAs (DE miRNAs) were identified between JH and LD groups. Gene ontology analysis suggested that DEGs were involved in oxidation-reduction, lipid biosynthetic and lipid metabolism process. Interaction network of DEGs and DE miRNAs were constructed, according to target prediction results. Conclusion: We generated transcriptome and miRNAome profiles of liver from JH and LD pig breeds which represent distinguishing phenotypes of growth and metabolism. The potential miRNA-mRNA interaction networks may provide a comprehensive understanding in the mechanism of lipid metabolism. These results serve as a basis for further investigation on biological functions of miRNAs in the porcine liver.
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Circular RNA expression profiles in the porcine liver of two distinct phenotype pig breeds
Huang, Minjie,Shen, Yifei,Mao, Haiguang,Chen, Lixing,Chen, Jiucheng,Guo, Xiaoling,Xu, Ningying Asian Australasian Association of Animal Productio 2018 Animal Bioscience Vol.31 No.6
Objective: An experiment was conducted to identify and characterize the circular RNA expression and metabolic characteristics in the liver of Jinhua pigs and Landrace pigs. Methods: Three Jinhua pigs and three Landrace pigs respectively at 70-day were slaughtered to collect the liver tissue samples. Immediately after slaughter, blood samples were taken to detect serum biochemical indicators. Total RNA extracted from liver tissue samples were used to prepare the library and then sequence on HiSeq 2500. Bioinformatic methods were employed to analyze sequence data to identify the circRNAs and predict the potential roles of differentially expressed circRNAs between the two breeds. Results: Significant differences in physiological and biochemical traits were observed between growing Jinhua and Landrace pigs. We identified 84,864 circRNA candidates in two breeds and 366 circRNAs were detected as significantly differentially expressed. Their host genes are involved in lipid biosynthetic and metabolic processes according to the gene ontology analysis and associated with metabolic pathways. Conclusion: Our research represents the first description of circRNA profiles in the porcine liver from two divergent phenotype pigs. The predicted miRNA-circRNA interaction provides important basis for miRNA-circRNA relationships in the porcine liver. These data expand the repertories of porcine circRNA and are conducive to understanding the possible molecular mechanisms involved in miRNA and circRNA. Our study provides basic data for further research of the biological functions of circRNAs in the porcine liver.
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Deng Yunfei,Zeng Xiaochen,Lv Yifei,Qian Zhiyuan,Guo Peijie,Liu Yi,Chen Shaoliang 생화학분자생물학회 2023 Experimental and molecular medicine Vol.55 No.-
The loss of cardiomyocytes (CMs) after myocardial infarction (MI) is widely acknowledged to initiate the development of heart failure (HF). Herein, we found that circCDYL2 (583 nt) derived from chromodomain Y-like 2 (Cdyl2) is significantly upregulated in vitro (oxygen-glucose deprivation (OGD)-treated CMs) and in vivo (failing heart post-MI) and can be translated into a polypeptide termed Cdyl2-60aa (~7 kDa) in the presence of internal ribosomal entry sites (IRES). Downregulation of circCDYL2 significantly decreased the loss of OGD-treated CMs or the infarcted area of the heart post-MI. Additionally, elevated circCDYL2 significantly accelerated CM apoptosis via Cdyl2-60aa. We then discovered that Cdyl2-60aa could stabilize protein apoptotic protease activating factor-1 (APAF1) and promote CM apoptosis; heat shock protein 70 (HSP70) mediated APAF1 degradation in CMs by ubiquitinating APAF1, which Cdyl2-60aa could competitively block. In conclusion, our work substantiated the claim that circCDYL2 could promote CM apoptosis via Cdyl2-60aa, which enhanced APAF1 stability by blocking its ubiquitination by HSP70, suggesting that it is a therapeutic target for HF post-MI in rats.
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