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Yi-Xin Zou,Jia Qiao,Hua-Yuan Zhu,Rui-Nan Lu,Yi Xia,Lei Cao,Wei Wu,Hui Jin,Wen-Jie Liu,Jin-Hua Liang,Jia-Zhu Wu,Li Wang,Lei Fan,Wei Xu,Jian-Yong Li 대한암학회 2019 Cancer Research and Treatment Vol.51 No.2
Purpose Chronic lymphocytic leukemia (CLL) is one of the most frequent type of B-cell chronic lymphoproliferative disorders and chronic inflammation takes part in the development of CLL. However, there has been no valid immune biomarker to predict the prognosis of untreated CLL patients. Materials and Methods In this retrospective study, we analyzed the clinical correlations and prognostic value of albumin-to-fibrinogen ratio (AFR) detected at diagnosis in 191 CLL patients. Results The cut-off value of AFR was 9.7 calculated by X-tile. Patients who were more than 65 years old were often accompanied by low level of AFR (p < 0.001). Survival analysis showed that patients with low level of AFR had shorter overall survival (OS) than patients with high level of AFR (p < 0.001). Multivariate analysis illustrated that AFR had a negative impact on OS (p=0.003) and was independent of parameters involved in CLL international prognostic index and other prognostic markers such as CD38 and ZAP-70. Conclusion These data provide a comprehensive view of AFR and shows that AFR at diagnosis is an adverse prognostic factor in untreated CLL patients.
Fabrication of silica/PVA‑co‑PE nanofiber membrane for oil/water separation
Yuanli Chen,Hui Fan,Xinlin Zha,Wenwen Wang,Yi Wu,Yi Xiong,Kun Yan,Yuedan Wang,Dong Wang 한국의류학회 2021 Fashion and Textiles Vol.8 No.1
High efficiency and anti-pollution oil/water separation membrane has been widely explored and researched. There are a large number of hydroxyl groups on the surface of silica, which has good wettability and can be used for oil-water separation membranes. Hydrophilic silica nanostructures with different morphologies were synthesized by changing templates and contents of trimethylbenzene (TMB). Here, silica nanospheres with radical pores, hollow silica nanospheres and worm-like silica nanotubes were separately sprayed on the PVA-co-PE nanofiber membrane (PM). The abundance of hydroxyl groups and porous structures on PM surfaces enabled the absorption of silica nanospheres through hydrogen bonds. Compared with different silica nanostructures, it was found that the silica/PM exhibited excellent super-hydrophilicity in air and underwater “oil-hating” properties. The PM was mass-produced in our lab through meltextrusion- phase-separation technique. Therefore, the obtained membranes not only have excellent underwater superoleophobicity but also have a low-cost production. The prepared silica/PM composites were used to separate n-hexane/water, silicone oil/ water and peanut oil water mixtures via filtration. As a result, they all exhibited efficient separation of oil/water mixture through gravity-driven filtration.
Yuan, Yuan,Cai, Hui,Yang, Xiao-Jun,Li, Wei,He, Jin,Guo, Tian-Kang,Chen, Yi-Rong Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.14
Background: The aim of this study was to investigate the effect of a c-myc antisense oligodeoxynucleotide and 5-fluorouracil on the expression of c-myc, invasion and proliferation of HEPG-2 liver cancer cells. Materials and Methods: HEPG-2 cells were treated with lipiosome-mediated c-myc ADSON and 5-fluorouracil. The proliferation inhibition rate and invasion were measured by MTT and invasion assay, respectively. Cell apoptosis was detected by flow cytometry and expression of c-myc by RT-PCR and immunohistochemistry. Results: The proliferation inhibition rate was significantly higher in the antisense oligodeoxynucleotide added-5-fluorouracil group than single antisense oligodeoxynucleotide or 5-fluorouracil group (p<0.05). G0/G1 cells in the antisense oligodeoxynucleotide group and S cells in the 5-fluorouracil groups were significantly increased than that in the control group, respectively (P<0.01). The amplification strips of PCR products in 5-FU, ASODN and combination groups were significantly weaker than that in the control group (P<0.01). The percentage of c-myc-protein-positive cells were significantly lower in antisense oligodeoxynucleotide, 5-fluorouracil and combination groups than that in the control group (P<0.01). Conclusions: A liposome-mediated c-myc antisense oligodeoxynucleotide and 5-fluorouracil can inhibit the proliferation and invasion of liver cancer cells by reducing the expression of c-myc. A c-myc antisense oligodeoxynucleotide can increase the sensitivity of liver cancer cells to 5-fluorouracil and decrease the dosage of the agent necessary for efficacy, providing an experimental basis for the clinical therapy of liver cancer.
Yi Hang Fan,Wen Yuan Wang,Zhao Peng Hao,Hengyi Yuan 한국정밀공학회 2021 International Journal of Precision Engineering and Vol.22 No.4
CBN (Cubic Boron Nitride) tool is suitable for precision machining of nickel-based alloy due to its high hardness and chemical inert. Nickel-based alloys are difficult-to-cut material. When high-speed cutting nickel-based alloys with CBN tool, the temperature at tool-workpiece interface is very high. The atoms in workpiece material diff use into the tool surface and change the performance of cutting tool, resulting in diffusion wear. Inconel 718, which is one kind of widely used nickel-based alloy, is mainly composed of nickel (Ni), iron (Fe) and chromium (Cr). In this paper, the cutting model which describes the single crystal CBN tool cutting Ni–Fe–Cr three-component alloy, and the compression and impact model of CBN tool crystal are established by using molecular dynamics (MD) method to study the diffusion of Ni, Fe and Cr atoms into CBN tool and the effects of diffusion on the properties of CBN crystal tool. The results show that the diffusion of Ni, Fe and Cr atoms into CBN tool decreases the compressive strength and impact toughness of CBN crystals and the effects degree of atom diffusion on the properties of CBN crystals are different.
Yuan, Zhi-Jun,Zhou, Wen-Wu,Liu, Wei,Wu, Bai-Ping,Zhao, Jin,Wu, Wei,He, Yi,Yang, Shuo,Su, Jing,Luo, Yi Asian Pacific Journal of Cancer Prevention 2015 Asian Pacific journal of cancer prevention Vol.16 No.10
Background: Previous studies showed that genetic polymorphisms of glutathione S-transferase P1 (GSTP1) were involved in glutathione metabolism and genetic polymorphisms of ribonucleotide reductase (RRM1) were correlated with DNA synthesis. Here we explored the effects of these polymorphisms on the chemosensitivity and clinical outcome in Chinese non-small cell lung cancer (NSCLC) patients treated with gemcitabine-cisplatin regimens. Materials and Methods: DNA sequencing was used to evaluate genetic polymorphisms of GSTP1 Ile105Val and RRM1 C37A-T524C in 47 NSCLC patients treated with gemcitabine-cisplatin regimens. Clinical response was evaluated according to RECIST criteria after 2 cycles of chemotherapy and toxicity was assessed by 1979 WHO criteria (acute and subacute toxicity graduation criteria in chemotherapeutic agents). Results: There was no statistical significance between sensitive and non-sensitive groups regarding the genotype frequency distribution of GSTP1 Ile105Val polymorphism (p>0.05). But for RRM1 C37A-T524C genotype, sensitive group had higher proportion of high effective genotype than non-sensitive group (p=0.009). And according to the joint detection of GSTP1 Ile105Val and RRM1 C37A-T524C polymorphisms, the proportion of type A (A/A + high effective genotype) was significantly higher in sensitive group than in non-sensitive group (p=0.009). Toxicity showed no correlation with the genotypes between two groups (p>0.05). Conclusions: Compared with single detection of genetic polymorphisms of GSTP1 Ile105Val or RRM1 C37A-T524C, joint detection of both may be more helpful for patients with NSCLC to receive gemcitabine-cisplatin regimens as the first-line chemotherapy. Especially, genetic polymorphism of RRM1 is more likely to be used as an important biomarker to predict the response and toxicity of gemcitabine-cisplatin combination chemotherapy in NSCLC.
Yi Yuan,Baolin Liu,Hao Liu 한국지질과학협의회 2022 Geosciences Journal Vol.26 No.3
Dongting Lake is the second-largest freshwater lake in China. To better understand the geochemical characteristics of the sediment in different seasons and identify the possible provenance, 44 sediment samples collected from East Dongting Lake (ED Lake) in summer (ED-S) and winter (ED-W) were used for elemental geochemical analysis. Geochemically, the sediment samples are classified as shale, and the chondrite normalized rare earth element (REE) patterns of the ED-S and ED-W have light REE (LREE) enriched, flat heavy REE (HREE) patterns with a negative Eu anomaly. In the present study, the correlations between certain elements show that the variations in ΣREE contents in sediments may be due to the concentrations of heavy minerals like monazite, whereas grain size is not responsible for that variations. Chemical index of alteration (CIA), plagioclase index of alteration (PIA) values, A-CN-K diagram, and Th/U ratios of the ED-S and ED-W sediment indicate a moderate to high intensity of chemical weathering in the source area. The Al2O3/TiO2 ratio, discriminant function diagram, REE patterns, and elemental ratios indicate the contribution of sediments from felsic and intermediate source rocks. The provenance index (PI) based on REEs geochemical parameters suggest that elemental compositions of sediment in East Dongting Lake approach the Upper Yangtze River.
Voltage Clamping Balance for Charging/Discharging Battery Module
Yi-Yuan Chung,Tsorng-Juu Liang,Wei-Jing Tseng,Jwo-Hann Liu 전력전자학회 2019 ICPE(ISPE)논문집 Vol.2019 No.5
This paper proposes a voltage clamping balance (VCB) method applied with battery power module (BPM) system. The VCB method, which indicates that battery balance is activated after the battery voltage reached its rated value, can save the cost of battery state of charge (SOC) estimation and increases system reliability while keeping the battery voltage in safe operating region. Otherwise, a VCB discharging experimental result shows that the proposed method can release more charge from battery than conventional discharging method in this paper. The proposed system composed of several BPMs and a system control circuit can provide energy as a DC voltage source in discharge mode, and can be charged by an external DC voltage source in charge mode. Meanwhile, the characteristics of BPM system such as high flexibility and capability of hot-swapping can be achieved by the proposed system. Finally, a 24-V LiFePO4 BPM system prototype containing 4 BPMs with 200-W power rating for each BPM is built to verify the feasibility of the proposed VCB method and the proposed BPM system.