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- 저자 : Yeye Hu (검색결과 3 건)
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A review of the immunomodulatory activities of polysaccharides isolated from Panax species
Yeye Hu,Yang He,Zhiqiang Niu,Ting Shen,Ji Zhang,Xinfeng Wang,Weicheng Hu a,Jae Youl Cho 고려인삼학회 2022 Journal of Ginseng Research Vol.46 No.1
Panax polysaccharides are biopolymers that are isolated and purified from the roots, stems, leaves, flowers, and fruits of Panax L. plants, which have attracted considerable attention because of their immunomodulatory activities. In this paper, the composition and structural characteristics of purified polysaccharides are reviewed. Moreover, the immunomodulatory activities of polysaccharides are described both in vivo and in vitro. In vitro, Panax polysaccharides exert immunomodulatory functions mainly by activating macrophages, dendritic cells, and the complement system. In vivo, Panax polysaccharides can increase the immune organ indices and stimulate lymphocytes. In addition, this paper also discusses the membrane receptors and various signalling pathways of immune cells. Panax polysaccharides have many beneficial therapeutic effects, including enhancing or activating the immune response, and may be helpful in treating cancer, sepsis, osteoporosis, and other conditions. Panax polysaccharides have the potential for use in the development of novel therapeutic agents or adjuvants with beneficial immunomodulatory properties.
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The potential of Panax notoginseng against COVID-19 infection
Yeye Hu,Ziliang He,Wei Zhang,Zhiqiang Niu,Yanting Wang,Ji Zhang,Ting Shen,Hong Cheng,Weicheng Hu 고려인삼학회 2023 Journal of Ginseng Research Vol.47 No.5
The COVID-19 pandemic has changed the world and has presented the scientific community with unprecedentedchallenges. Infection is associated with overproduction of proinflammatory cytokines secondaryto hyperactivation of the innate immune response, inducing a cytokine storm and triggeringmultiorgan failure and significant morbidity/mortality. No specific treatment is yet available. For thousandsof years, Panax notoginseng has been used to treat various infectious diseases. Experimental evidenceof P. notoginseng utility in terms of alleviating the cytokine storm, especially the cascade, andimproving post-COVID-19 symptoms, suggests that P. notoginseng may serve as a valuable adjuncttreatment for COVID-19 infection.
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Shengqiang Han,Long You,Yeye Hu,Tingwu Liu,Jae Youl Cho,Weicheng Hu,Shuai Wei The Korean Society of Ginseng 2023 Journal of Ginseng Research Vol.47 No.3
Background: Ginsenoside F2 (GF2), a minor component of Panax ginseng, has been reported to possess a wide variety of pharmacological activities. However, its effects on glucose metabolism have not yet been reported. Here, we investigated the underlying signaling pathways involved in its effects on hepatic glucose. Methods: HepG2 cells were used to establish insulin-resistant (IR) model and treated with GF2. Cell viability and glucose uptake-related genes were also examined by real-time PCR and immunoblots. Results: Cell viability assays showed that GF2 up to 50 μM did not affect normal and IR-HepG2 cell viability. GF2 reduced oxidative stress by inhibiting phosphorylation of the mitogen-activated protein kinases (MAPK) signaling components such as c-Jun N-terminal kinase (JNK), extracellular signal-regulated kinase 1/2 (ERK1/2), and p38 MAPK, and reducing the nuclear translocation of NF-κB. Furthermore, GF2 activated PI3K/AKT signaling, upregulated the levels of glucose transporter 2 (GLUT-2) and GLUT-4 in IR-HepG2 cells, and promoted glucose absorption. At the same time, GF2 reduced phosphoenolpyruvate carboxykinase and glucose-6-phosphatase expression as well as inhibiting gluconeogenesis. Conclusion: Overall, GF2 improved glucose metabolism disorders by reducing cellular oxidative stress in IR-HepG2 cells via MAPK signaling, participating in the PI3K/AKT/GSK-3β signaling pathway, promoting glycogen synthesis, and inhibiting gluconeogenesis.
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