대기오염에 있어서 오존형성에 관한 모사 및 모델인식

여영구,오세천 漢陽大學校 環境工學硏究所 1998 環境科學論文集 Vol.19 No.-

광화학적 대기오염에 있어서의 오존형성을 규명하기 위하여 빛의 강도, 반응물의 초기 농도 그리고 온도 및 습도의 영향을 고려한 반응 모델식을 이용하여 ?? 시스템에 대한 모사연구를 수행하였으며 습도의 영향을 고려하기 위하여 H₂O에 의한 N₂O5의 손실반응을 고려하였다. 모사결과는 smog-chamber 실험결과와 잘 일치하였다. 또한 본 연구에서는 오존 발생 예측 시스템의 개발에 있어서 쌍일차 모델의 성능 및 효용성을 확인하기 위하여 오존 발생량에 대하여 쌍일차 모델 및 선형 모델을 이용한 모델인식 모사실험을 하였다. 모델인식에 있어서는 ARMA 모델을 사용하였으며 모델의 파라미터를 평가하기 위하여 방정식 오차법에 근거한 연속 파라미터 평가 알고리즘을 적용하였다. 모델인식 실험결과로부터 쌍일차 모델을 이용한 오존 발생량과 본 연구에서 개발한 모사기로부터 얻은 오존 발생량이 거의 일치함을 알 수 있었다. The simulation of ?? system was performed by using a detailed reaction model in order to characterize ozone formation in photochemical air pollution. To consider the effect of humidity the loss reactions of ?? by H₂O were included in the model developed in the present study. The results of simulations showed a good agreement with smog-chamber experimental data. To verify the performance and effectiveness of bilinear model for the development of ozone prediction system the simulation experiments of the model identification for ozone formation were performed by using bilinear and linear models ARMA model was used in the model identification. A recursive parameter estimation algorithm based on an equation error method was used to estimate parameters of model. From the results of model identification experiment, the ozone formation by bilinear model showed good agreement with the ozone formation from the simulator developed in this study.

산주의 삼림투자 인식에 관한 연구 : 강원도지역을 중심으로

서영완,최종천 강원대학교 삼림과학연구소 2000 Journal of Forest Science Vol.16 No.-

일반산주와 임업후계자 · 독림가의 산림 투자 인식을 비교분석한 결과 다음과 같이 임 · 독림가가 일반산주보다 산림투자에 대하여 상대적으로 높은 관심을 보이고 있었다. 1.일반현황의 비교에서 임 · 독림가가 일반산주보다 교육수준과 월평균소득 면에서 높게 나왔으며, 직업의 경우 임 · 독립가는 다양한 직종에 종사하고 있는 반면 일반산주는 농업에 편중되어 있는 것으로 나타났다. 2.산림의 소유동기에서 임 · 독림가의 경우 일부상속 · 일부매입이 41.2%로 가장 많은 반면, 일반산주의 경우는 선대로부터의 상속이 40.9%로 가장 많았다. 3.산림투자에 대한 산주태도에서 임 · 독림가가 일반산주보다 과거 5년동안 산림투자 경험과 정부지원 신청경험 모두 높게 나타났다. 4.정부지원 제도에 대한 인식에서 일반산주보다 임 · 독림가가 정부지원 제도에 대하여 상대적으로 많이 알고 있는 것으로 나타났으며, 정부지원 제도의 실행상태에 대해서는 임 · 독림가와 일반산주 모두 '그저 그렇다'는 미온적인 반응을 가장 많이 보였다. The study is focused on comparing the perception of forest investment by two types of forest owners, ordinary forest owners (OFOs) and forestry successors and model forest owners(FSMFOs). The results show that FSMFOs' perception of forest investment is relatively high compared with OFOs' perception The details are as follows ; 1.In the general status, the education and income levels of FSMFOs are higher than those of OFOs, and FSMFOs are engaged in various kinds of jobs while OFOs are inclined to lean toward farming. 2.Of the motives to own forests, partial-purchase and -inheritance is the most of FSMFOs(41.2% ) and inheritance the most of OFOs (40.9% ) 3.The number of FSMFOs who had made forest investment and applied government support is more than that of OFOs. 4.FSMFOs know government support better than OFOs do, while both show lukewarmness on weather the support is carried out according to the rules. Key words : forest investment, forestry successor, government support

통계적 방법을 이용한 오존 형성의 예측

여영구,손상현,오세천 漢陽大學校 環境工學硏究所 1999 環境科學論文集 Vol.20 No.-

통계적 방법을 이용하여 오존 형성의 예측에 관한 연구를 수행하였다. 통계적 방법으로는 파라미터 평가 방법과 인공신경 회로망 방법이 적용되었다. 파라미터 평가 방법에는 실시간 파라미터를 평가하기 위하여 ELS 및 RML 방법이 사용되었으며 오존 형성의 모델로는 ARMAX 모델을 사용하였다. 또한 3층 구조를 갖는 인공신경 회로망 방법을 이용하여 오존 형성의 예측 시험을 수행하였으며 본 연구에 사용된 통계적 방법의 성능을 평가하기 위하여 오존 형성의 예측결과를 실제자료와 비교 분석을 하였다. 실제 자료와의 비교를 통하여 파라미터 평가 방법 및 인공신경 회로망 방법에 근거한 예측방법이 제한된 예측 구간 내에서 만족할 만한 성능을 보임을 확인할 수 있었다. The prediction of ozone formation was studied using the stochastic method, Parameter estimation method and artificial neural network(ANN) method were employed in the stochastic scheme. In the parameter estimation method, extended least squares(ELS) method and recursive maximum likelihood(RML) were used to achieve the real time parameter estimation. Autoregressive moving average model with external input(ARMAX)was used as the ozone formation model for the parameter estimation method, ANN with 3 layers was also tested to predict the ozone formation. To demonstrate the performance of the ozone formation prediction schemes used in this work, the prediction results of ozone formation were compared to the real data. From the comparison it was found that the prediction schemes based on the parameter estimation method and ANN method show an acceptable accuracy with limited prediction horizon.

[Gln]1.4,[Phe]11 - Neurotensin 의 합성

박두천,홍남주,박영택 國立 昌原大學校 産業技術硏究所 1989 産技硏論文集 Vol.3 No.-

흙의 파괴시 체적변화 효과

정진섭,권영언,김찬기,이종천 圓光大學校 1993 論文集 Vol.27 No.2

본 연구는 흙이 파괴할 때 전단에 의하여 발생 하는 채적변화에 의한 응력을 보정하는 세개의 방정식을 유도하여 문헌상에서 얻은 시험결과에 적응하여 본 결과 Bishop의 에너지를 고려한 보정방법이 가장 합리적인 것으로 생각되어 Bishop의 방법을 선택하여, 흙이 항복 및 파괴 할 때에 채적변화에 대한 응력보정의 효과를 Poorooshasb모델과 Lade모델에서 검토하였다. 그 결과 전단할 때 채적변화에 대한 응력보정은 흙의 파괴상태를 합리적으로 나타내지 못한다는 사실을 알았다. The effect of volume change at failure and equations worked out to aollow for their contribution to the stresses. Two models for the failure and yield of soil are discussed in this paper and the effects of the corrections are considered in these models. The corrections for volume change do not produce a reasonable change in the stresses. They do not make the task of modeling the soil any simpler, and so not nessecery for consideration. The best method developed so far, describing the failure of the soil is Lade`s model. It describes the failure of the soil very well without volume correction. In fact when volume corrections are applied, the model no longer describes the failure. Poorooshasb`s model, though base on much consideration does not describe the true failure of the soil.

肺炎 誘發菌의 生育을 抑制하는 韓藥材 探索에 關한 硏究

정병운,서운교,정지천,한영환 동국대학교 한의학연구소 1999 東國韓醫學硏究所論文集 Vol.7 No.2

韓藥材 중 肺炎의 치료효과가 기대되는 淸熱化痰, 止咳平喘藥을 중심으로 23種의 藥材를 사용하여 肺炎을 유발하는 K. pneumoniae, S. pyogenes 및 S. pneumoniae 세균의 생육을 억제하는 藥材를 탐색하고, 탐색된 藥材의 추출물에 대한 세균의 最小生育抑制濃度를 측정하였다. 韓藥材의 水溶性 추출물 중 黃連, 胡黃蓮, 敗醬, 黃芩이 K. pneumoniae에서, 黃連이 S. pyogenes에 대해서 생육억제 효과가 있었으며, S. pneumoniae에 대한 比較沮止環의 直徑은 黃連, 鳥梅, 五味子, 黃芩이 우수하였으나 黃連 추출물 사용시 병원균 모두에서 生育沮止環의 크기가 가장 크게 나타났으며 對照群로 사용된 大腸菌과 枯草菌에서도 어느 정도의 抗細菌 효과를 볼 수 있었다. 에탄올 추출물에서는 敗醬, 黃芩, 五味子, 鳥梅가 K. pneumoniae 세균의 생육을 억제하였으며, S. pyogenes 세균은 黃連, 五味子, 鳥梅, 馬兜鈴찾, 黃芩에 의하여 생육이 억제되어 黃連은 水溶性 및 에탄올 溶解性 주출물에서 모두 우수한 抗細菌 효과를 보여주고 있다. 각 세균에 대한 最小生育沮止濃度(MIC)는 K. pneumoniae 세균일 경우 黃連 및 黃芩의 水溶性 추출물과 鳥梅 및 敗醬의 에탄올 溶解性 추출물이 유의성을 보였으며, S. pyogenes 세균은 黃連의 水溶性 및 에탄올 溶解性 추출물과 鳥梅의 에탄올 溶解性 추출물, S. pneumoniae 세균은 黃連과 鳥梅의 水溶性 및 에탄올 溶解性 주출물에서 유의성이 나타났다. 이상의 결과를 통하여 黃連, 五味子, 鳥梅, 黃芩, 胡黃蓮, 敗醬의 水溶性 및 에탄올 溶解性 추출물이 肺炎 誘發菌f K. pneumoniae, S. pyogenes, S. pneumoniae에 對하여 우수한 生育抑制 作用을 나타냄을 알 수 있었다. The various oriental herbal medicines, which have usually been used for treatment of reducing fever, purging intense heat and detoxication, were screened to determine the antibacterial activity and the minimal inhibitory concentration against pulmonary disease-causing Klebsiella pneumoniae, Streptococcus pyogenes, and Streptococcus pneumoniae. The results obtained were as follows: 1. Among the 23 oriental medicines tested, the water-soluble extracts of Coptis japonica, Scutellaria baicalensis and Picrorrhiza kurroca showed the antibacterial activity against K. pneumoniae and that of C. japonica against S. pyogenes. The antibacterial activities of C. japonica, Prunus mume, Schizandra chinesis, Scutellaria baicalensis were also found against S. pyogenes. When C. japonica was used, the high antibacterial activity was shown against Bacillus subtilis and other extracts showed a little activity against B. subtilis and E. coli as a control. 2. The ethanol-soluble extracts of Patrinia scabriosaefolia, P. mume, S. baicalensis, S. chinensis showed the antibacterial activity against K. pneumoniae and those of S. baicalensis, C. japonica, S. chinensis P. mume against S. pyogenes and S. pneumoniae. However, those extract showed a little antibacterial activity against B. subttilis and E. coli except for that the extract of C. japonica showed comparatively high growth inhibition of B. subtilis. 3. Among the medicinal herbs tested, the water- and ethanol extracts of C. japonica showed very extcellent antibacterial activity against the pathogenic bacteria and controls. 4. When the water-soluble extracts of C. japonica and S. baicalensis, minimal inhibitory concentrations (MICs) against K. pneumoniae were 10 ㎎/㎖ and 22 ㎎/㎖, respectively. The MICs of the ethanol-soluble extracts of P. mume and P. scabriosaefolia were 5 ㎎/㎖ and 20 ㎎/㎖, respectively. 5. For the MICs against S. pyogenes, C. japonica showed 15 ㎎/㎖ with the water-soluble extract and P. mume and C. japonica with the ethanol-souble extract did 5 ㎎/㎖ and 10 ㎎/㎖, respecitively. 6. For the MICs against S. pneumoniae, C. japonica and P. mume with the water- and ethanol-souble extract showed 5 ㎎/㎖ and 10 ㎎/㎖, respecitively. As a result, the highest antibacterial activity was found in the water- and ethanol-soluble extracts of C. Japonica against pulmonary disease-causing bacteria, K. pneumoniae, S. pyogenes, and S. pneumoniae. Also, the water- and ethanol-soluble extracts of S, chinensis, P. mume, S. baicalensis and P. kurrooa showed high antibacterial activities.

피부 병변을 동반한 악성조직구증 1예

조은택,박용관,김진호,강정원,천영욱,전익섭,박유환,전춘해 조선대학교 1995 The Medical Journal of Chosun University Vol.20 No.1

Malignant histiocytosis, originally described in 1939 as histiocytic medullary reticulosis by Scott and Robb-Smith, is a rare histiocytic proliferative disorder that often shows an acute onset and used to progress to death within a few months. This disorder characterized clinically by fever, generalized weakness, lymphadenopathy and hepatosplenomegaly, and shows a variable range of pancytopenia. Extranodal involvement is common, with an incidence ranging from 50% to as high as 90%, skin involves8ment was noted in 10% to 15%. Typical skin lesions were mainly founded in extremity. i.e. erythematous papule and nodule occasionally become to necrosis and ulceration. We experienced one case of malignant histiocytosis in a 46-years-old female. The major clinical findings are fever, malaise, hepatosplenomegaly and erythematous skin lesion. In the laboratory study, pancytopenia is noted on the peripheral blood. And also aggregation of many atypical histiocytes were shown on skin and bone marrow biopsy. So we reported one related case with malignant histiocytosis as well as reviewing literature .

장기 이식 환자에서 Voriconazole 과 Cyclosporine 또는 Tacrolimus의 상호작용

한혜원,김재연,송영천,김승은,유성길 한국병원약사회 2009 병원약사회지 Vol.26 No.1

Abstract: In organ transplant patients, the opportunity of fungi infections such as invasive aspergillosis increase by use of immunosuppresant drugs and voriconazole is recommended as primary treatment drug. When voriconazole is administered with cyclosporine(CsA) or tacrolimus(FK506), caution about increment of blood CsA or FK506 concentrations that caused by the change of CYP3A4 activity is required but few domestic cases of interaction were reported yet, The purpose of this study was to assess the effect of voriconazole on the blood CsA or FK506 concentrations in transplant recipients and the factors of recipients that have an effect on the results. 25 transplant recipients who were administered voriconazole with CsA or FK506 from January 1 of 2006 to August 17 of 2008 in Asan Medical Center were objects (12 patients on CsA coadministration arm - 9 males, 3 females; 41~62years;2 liver, 2 kidney, 3 bone marrow, 5 heart transplant recipients, and 13 on FK506 coadministration arm - 7 males, 6 females;26~65years; 10 liver, 2 kidney, 1 heart transplant recipients). Blood CsA or FK506 concentrations before and after coadministration of voriconazole, and maximum concentration in one month from the first day of coadministration were monitored retrospectively. In most cases CsA or FK506 were administered as recommended doses regardless of coadministration of voriconazole, and blood concentration increased from 239.42±126. 77ng/ml to maximum 411.92±225. 76ng/ml in CsA coadministration arm(p=0.003), and from 7.72±2.79ng/ml to maximum 19.16±9.35ng/ml in FK506 coadministration arm(p=0.003). Gender, age, and the kind of transplant organ did not affect to the change of blood concentration in both two arms. In consequences, administration of voriconazole could affect on the blood CsA or FK506 concentration, and in cases of administra tion of voriconazole in transplant recipients treated with CsA or FK506, close monitoring and dose adjustment is needed.

λ-경쇄형 다발성 골수종 1예

박용관,김태원,장영,김진호,강정원,천영욱,박유환,정춘해 조선대학교 1995 The Medical Journal of Chosun University Vol.20 No.1

Multiple myeloma is a disease caused by neoplastic plasma cells that synthesize abnormal amouts of immunoglobulin or immunoglobulin fragments. Light chain myeloma are regarded as a separate category characterized by a more malignant clinical course. Light chain myelomas are said to grow fastest of all and are associated with more osteolytic lesions, more hypercalcemia, and a higher incidence of renal failure and amyloidsis than either the IgG, IgA varienties The authors experienced a case of patients with λ-light chain myeloma. A 43-year-old male patient admitted to our hospital with the chief complaint of both rib and lower back pain. The radiologic findings showed multiple pathologic fracture in ribs. osteolytic lesions in 2nd, 3rd cervical spineimmuture plasma cells. Serum electrophoresis showed normal finding. Urine electrophoresis evealed an M-spike. Urine immunoelectrophoress demonstrated λ-monoclonal protein. With the cycle of melphalan, prednisone and α-interferon chemotherapy improved of pain was observed. So we reported the case with brief review of previous literature.

대한간학회지 제8차 춘계학술대회 초록집 : 포스터 전시 ; 간의 염증성 가성 종양 1예

장재영 ( Jang Jae Yeong ),김연수 ( Kim Yeon Su ),천영국 ( Cheon Yeong Gug ),김영석 ( Kim Yeong Seog ),김정훈 ( Kim Jeong Hun ),문종호 ( Mun Jong Ho ),조영덕 ( Jo Yeong Deog ),진소영 ( Jin So Yeong ),심찬섭 ( Sim Chan Seob ),김부성 대한간학회 2002 Clinical and Molecular Hepatology(대한간학회지) Vol.8 No.2(S)