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Sung, Eun-Jung,Yoo, Seung-Schik,Yoon, Hyo Woon,Oh, Sung-Suk,Han, Yeji,Park, Hyun Wook Informa Healthcare 2007 International journal of neuroscience Vol.117 No.7
<P> The aim of this study was to identify the activated brain region that is involved with the affective dimension of thermal stimulation (not pain, but innocuous warming) using functional MR imaging. Twelve healthy, right-handed male subjects participated in the study. Thermal stimulation with two different temperatures of 41°C and 34°C was applied to the subjects using a fomentation pack, wrapped around the right lower leg of each subject. On the basis of the subjects' responses after the scanning sessions, the authors were able to observe that the subjects felt "warm" and "slightly pleasant and comfortable" under the 41°C condition. The experimental results indicated that warm stimulation produced a significant increase of activation compared to thermal neutral stimulation in various regions such as contralateral insular, ipsilateral cerebellum, ipsilateral putamen, contralateral middle frontal gyrus, ipsilateral inferior frontal gyrus, contralateral postcentral gyrus, and contralateral paracentral lobule. The activated regions are known to be related to thermal sensory, affective/emotional awareness, cognitive functions, sensory-discrimination, and emotion/affective processing, and so on. These results suggest that an appropriate thermal stimulation can produce a positive emotion and activate emotion/affect related regions of the brain.</P>
성은정 ( Eun Jung Sung ),운효운 ( Hyo Woon Yoon ),오성석 ( Sung Suk Oh ),한예지 ( Yeji Han ),박현욱 ( Hyun Wook Park ) 한국감성과학회 2004 추계학술대회 Vol.2004 No.-
본 연구는 fMRI(기능적자기공명영상)를 이용하여 온열 자극시 유발되는 감성과 관련된 뇌활성 영역을 알아보고자 하였다. 건강한 남자 성인 12명을 대상으로 우측 하퇴부위에 41"C 온열팩으로 온열자극을 가하였을 때가 thermoneutral (34 ``C)에 비하여 주관적으로 더 쾌적하다고 평가하였고, 대뇌의 insular, putamen, frontal gyrus에서 유의하게 활성화 된 것으로 나타났다. 따라서 적절한 온열자극은 positive emotion을 유도할 수 있고, 그에 따라 emotion과 관련한 뇌영역에서 활성화가 일어난 것을 확인할 수 있었다.
Microbiota-Derived Lactate Accelerates Intestinal Stem-Cell-Mediated Epithelial Development
Lee, Yong-Soo,Kim, Tae-Young,Kim, Yeji,Lee, Su-Hyun,Kim, Seungil,Kang, Sung Wan,Yang, Jin-Young,Baek, In-Jeoung,Sung, Young Hoon,Park, Yun-Yong,Hwang, Sung Wook,O, Eunju,Kim, Kwang Soon,Liu, Siqing,Ka Elsevier 2018 Cell host & microbe Vol.24 No.6
<P><B>Summary</B></P> <P>Symbionts play an indispensable role in gut homeostasis, but underlying mechanisms remain elusive. To clarify the role of lactic-acid-producing bacteria (LAB) on intestinal stem-cell (ISC)-mediated epithelial development, we fed mice with LAB-type symbionts such as <I>Bifidobacterium</I> and <I>Lactobacillus</I> spp. Here we show that administration of LAB-type symbionts significantly increased expansion of ISCs, Paneth cells, and goblet cells. Lactate stimulated ISC proliferation through Wnt/β-catenin signals of Paneth cells and intestinal stromal cells. Moreover, <I>Lactobacillus plantarum</I> strains lacking lactate dehydrogenase activity, which are deficient in lactate production, elicited less ISC proliferation. Pre-treatment with LAB-type symbionts or lactate protected mice in response to gut injury provoked by combined treatments with radiation and a chemotherapy drug. Impaired ISC-mediated epithelial development was found in mice deficient of the lactate G-protein-coupled receptor, Gpr81. Our results demonstrate that LAB-type symbiont-derived lactate plays a pivotal role in promoting ISC-mediated epithelial development in a Gpr81-dependent manner.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Symbiont-generated lactate is critical for Lgr5<SUP>+</SUP> ISC-mediated epithelial development </LI> <LI> Lactate signals through the G-protein-coupled receptor Gpr81 to elicit ISC proliferation </LI> <LI> <I>Lactobacillus plantarum</I> lacking lactate dehydrogenase fails to induce ISC regeneration </LI> <LI> Pre-feeding of lactate protects mice from chemotherapy- and radiation-induced gut damage </LI> </UL> </P> <P><B>Graphical Abstract</B></P> <P>[DISPLAY OMISSION]</P>
( Yeji Han ),( Eunmi Nam ),( Kyungeun Lee ),( Youngchul Moon ),( Joomyung Sung ),( Kyungmin Cho ),( Jungeun Choi ),( Jooyoung Kim ) 대한내과학회 2014 대한내과학회 추계학술대회 Vol.2014 No.1
Background: Posterior reversible encephalopathy syndrome (PRES) is known to have symptoms of headache, visual disturbances, altered consciouseness and seizures, which can be result of acute hypertension, eclampsia, renal failure and the use of immunosuppressive or cytotoxic agents. We report a case of PRES ocurred as a result of FOLfiRI (irinotecan, 5-FU) chemotherapy in metastatic colorectal cacer/ Case Report: A 51-year old male with diagnosed of rectal cancer with liver metastasis, underwent an a low anterior resection on April,19, 2013.After operation, he has XELOX (capecitabine, oxaliplatin) as palliative chemotherapy. After sixth XELOX chemotherapy, chemotherapy as change of disease progression. When FOLfiRI chemotherapy administered, suddenly he appeared to have partial seizure with sudden eyeball deviation . The infusion of chemotherapy was stopped immediately ,he had treatment with anticonvulsants, such as phenytoin, levetiracetam. The brain MRI showed that white matter change in the bilateral occipital lobe, supported the diagnosis of PRES. The conservative treatment was continued for several days. After few days, the patient recovered from symptom and after that, he had chemotherapy XELOX and bevacizumab instead of FOLfiRI. The brain MRI after six months did not show any previous lesion, he is currently well being followed up as an outpatient. Conclusion: There are no known reports of the association between PRES and FOLfiRI chemotherapy.We postulate that FOLfiRI chemotherapy can disrupt the normal endothelial function of the brain leading to the development of PRES.
( Yeji Han ),( Hye-kyung Jung ),( Ji Young Chang ),( Chang Mo Moon ),( Seong-eun Kim ),( Ki-nam Shim ),( Sung-ae Jung ),( Joo-young Kim ),( Ji-yun Bae ),( Sae-in Kim ),( Ji-hyun Lee ),( Sanghui Park ) 대한내과학회 2017 The Korean Journal of Internal Medicine Vol.32 No.5
Background/Aims: Duodenitis is not infrequent finding in patient undergoing endoscopy. However, hospitalized patients have a higher incidence of secondary duodenal mucosal lesions that might be related with inflammatory bowel disease (IBD), cytomegalovirus (CMV) infection, tuberculosis, immunologic disorders, or other rare infections. We aimed to identify clinicopathologic features of duodenal mucosal lesions in hospitalized patients. Methods: All hospitalized patients having duodenal mucosal lesions were identi-fied by endoscopic registration data and pathologic data query from 2011 to 2014. The diagnostic index was designed to be sensitive; however, a detailed review of medical record and endoscopic findings was undertaken to improve specificity. Secondary duodenal lesion was defined as having specific reason to explain the duodenal lesion. Results: Among 6,334 hospitalized patients have undergone upper endoscopy, en-doscopic duodenal mucosal lesions was detected in 475 patients. Secondary duo-denal lesions was 21 patients (4.4%) and the most frequent secondary cause was IBD (n = 7). The mean age of secondary group was significantly lower than that in primary group (42.3 ± 18.9 years vs. 58.5 ± 16.8 years, p = 0.00), and nonsteroidal anti-inflammatory drugs were less frequently used in secondary group, but there was no differences of gender or presence of Helicobacter pylori. The involvement of distal part of duodenum including postbulbitis or panduodenitis was more fre-quently detected in secondary group than in primary group. By multivariate re-gression analysis, younger age of 29 years and the disease extent were significant predictors for the secondary mucosal lesions. Conclusions: Secondary duodenal mucosal lesions with different pathophysiol-ogy, such as IBD or CMV infection, are rare. Disease extent and age seems the most distinctive feature of secondary duodenal mucosal lesions.