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Pharma-Biotics, Strain X, Inhibits Inflammation of Non-Alcoholic Fatty Liver Disease
( Ye Rin Choi ),( Hyeong Seop Kim ),( Hee Jin Park ),( Ji Ye Hyun ),( Jung A Eom ),( Min Kyo Jeong ),( Byeong Hyun Min ),( Sang Jun Yoon ),( Satya Priya Sharma ),( Haripriya Gupta ),( Yoseph Asmelash 대한간학회 2021 춘·추계 학술대회 (KASL) Vol.2021 No.1
김예린(Ye-rin Kim),양서윤(Seo-yoon Yang),문희원(Hee-won Moon),한나경(Na-gyung Han),김예진(Ye-jin Kim) 한국정보통신학회 2023 한국정보통신학회 종합학술대회 논문집 Vol.27 No.1
본 논문에서는 구글 티처블머신을 이용한 페트병 분리수거 유도 및 보상 시스템을 설계·제작하였다. 설계된 시스템은 영상 검출부, 제어부, 음성출력부 및 사용자 인식부로 구성된다. 영상 검출부는 머신러닝 카메라를 이용하여 페트병을 감지해 라벨과 뚜껑 유무를 검출한다. 검출된 결과가 특정 기준범위를 벗어난 경우 그 결과를 아두이노를 이용한 제어부에 전송한다. 제어부에서는 검출부로부터 전달 받은 결괏값에 따라서 수거함의 입구를 서보모터를 이용하여 개폐한다. 또한, 음성 출력부를 제어하고 사용자 인식부에 통보하는 기능도 수행한다. 사용자 인식부에서는 NFC카드를 통해 사용자를 인식하여 포인트가 적립되도록 하였다. 이를 통해 사용자들의 적극적인 분리수거가 유도되기를 기대한다. In this paper, a separate collection guidance and compensation system for PET bottles using Google Teachable Machine was designed and produced. The designed system consists of an image detection unit, a control unit, an audio output unit, and a user recognition unit. The image detection unit uses a machine learning camera to detect PET bottles and detects the presence of labels and caps. If the detected result is out of a specific standard range, the result is transmitted to the control unit using Arduino. The control unit opens and closes the entrance of the collection box using a servo motor according to the result value received from the detection unit. It also controls the voice output unit and performs a function of notifying the user recognition unit. The user recognition unit recognizes the user through the NFC card so that points are accumulated. Through this, it is expected that users will be encouraged to actively separate collection.
Yoon, Jihyun,Oh, In-Hwan,Seo, Hyeyoung,Kim, Eun-Jung,Gong, Young-hoon,Ock, Minsu,Lim, Dohee,Lee, Won Kyung,Lee, Ye-Rin,Kim, Dongwoo,Jo, Min-Woo,Park, Hyesook,Yoon, Seok-Jun The Korean Academy of Medical Sciences 2016 JOURNAL OF KOREAN MEDICAL SCIENCE Vol.31 No.suppl2
<P>This study is part of a 5-year research project on the national burden of diseases, injuries, and risk factors in Korea. Using disability-adjusted life years (DALYs), a metric introduced by the 1990 Global Burden of Disease (GBD) project, we performed a comprehensive and detailed assessment of the magnitude and distribution of both fatal and non-fatal health problems in the Korean population. The concept and general approach were consistent with the original GBD study, with some methodological modifications to make the study more suitable for Korea. We computed DALYs for 313 causes in both sexes and nine age groups using the entire population's medical records and newly generated Korean disability weights. In 2012, the dominant disease burden was non-communicable diseases, which accounted for 85.21% of total DALYs, while injuries accounted for 7.77% and communicable, maternal, neonatal, and nutritional disorders for 7.02%. Of the total DALYs, 88.67% were from years lived with disability and 11.32% were from years of life lost due to premature mortality. Diabetes mellitus was the leading cause of DALYs, followed by low back pain, chronic obstructive pulmonary disease, ischemic heart disease, ischemic stroke, cirrhosis of the liver, falls, osteoarthritis, motorized vehicle with three or more wheels, and self-harm. The results reported here identify key health challenges and opportunities for future health interventions and policy changes, and provide information that will help assess the major public health issues in Korea, a nation faced with one of the world's most rapidly ageing populations.</P>
Sufficient Calorie Intake Ameliorates Cognitive Impairment in Alcoholic Liver Disease
( Ye Rin Choi ),( Min Jea Shin ),( Gi Soo Youn ),( Sang Jun Yoon ),( Haripriya Gupta ),( Na Young Lee ),( Hyeong Seop Kim ),( Dong Joon Kim ),( Ki Tae Suk ) 대한간학회 2020 춘·추계 학술대회 (KASL) Vol.2020 No.1
Aims: Alcoholic liver disease (ALD) is the most common cause of chronic liver disease. And cognitive dysfunction is one of the complications and associated with calorie intake in ALD. However, relation between nutrition and cognitive function has not been fully evaluated. The aim of this study is to explore the effect of diet on cognitive function in ALD. Methods: A total of 43 patients were enrolled and neuropsychological tests assessed according to the nutritional state (BMI<21.7 and BMI≥21.7). In animal study, mice were sub-divided into 4 groups (n=9/group; control (5% EtOH liquid diet), low fat (5% EtOH+low fat diet), high fat (5% EtOH+high fat diet), and high protein (5% EtOH+high protein diet)) for 8 weeks. For the cognitive function, we performed T-maze study weekly before and after alcohol binge. Results: In the comparison of cognitive function (BMI<21.7 and BMI≥21.7), language score of Korea mini-mental state (7.37 ± 1.4 and 7.85 ± 0.4 P=0.04), rey-complex figure (72.0±25.9 and 58.4±33.6, P=0.05), boston naming (11.7±2.7 and 13.0±1.8, P=0.02), forward digit span (6.7±1 .8 and 7.5±1.6, P=0.04), Korean-color word stroop (24.2±26.5 and 43.6±32.4, P=0.006), interference score (33.9±31.9 and 52.3±33.9, P=0.02) showed high scores in BMI≥21.7 group. In the animal study on day 40, all groups shortened the time to find feed (low fat: P=0.004, high fat: P=0.02) compared to the control group. Interestingly, binge drinking mice reduced the time than before trained mice. Conclusions: ALD patients with BMI<21.7 enhance their cognitive dysfunction. Although it needs more studies which correlation of calorie intake and cognitive function, this study indicates that sufficient intake of calories provides major benefits for preventing cognitive dysfunction.
Ye Ryoung Jang,Hye Rin Yoon,Mi Hyoung Kim,Hong Gu Joo 한국예방수의학회 2018 예방수의학회지 Vol.42 No.2
Doxorubicin has been used to treating cancers, including breast cancer, bladder cancer, and acute lymphocytic leukemia, however, few studies have investigated its anti-inflammatory activity. In this study, we used mouse spleen cells treated with lipopolysaccharide (LPS), a representative inflammatory agent to investigate the effects of doxorubicin. Specially, we investigated the effects of doxorubicin on metabolic activity, cell size, cell death, and cytokine production of LPS-treated spleen cells. Doxorubicin significantly decreased the metabolic activity, even when applied at relatively low concentrations (1.6-8 ng/mL). To investigate the potential mechanism, we measured the mitochondrial membrane potential (MMP) of the LPS-treated spleen cells using Rhodamine 123. Doxorubicin decreased MMP and cell size, and induced cell death. Furthermore, doxorubicin suppressed the production of tumor necrosis factor (TNF)-alpha, a representative cytokine, in LPS-treated spleen cells. Taken together, doxorubicin decreased metabolic activity and the production of inflammatory cytokines, while increasing the death of LPS-induced hyperactivated spleen cells. This results will enable broader application of doxorubicin, as an anti-inflammatory agent, in clinical and research fields.