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Shortening of Calculation Time in the Finite Element Structure Analysis
Yoshitaka Nakamura,Yasuyuki Miyazaki 한국항공우주학회 2008 한국항공우주학회 학술발표회 논문집 Vol.- No.-
In nonlinear structure analysis, most of the calculation time is spent computing the inverse matrix of the stiffness matrix. In the present paper, the compliance modification method, in which the compliance matrix is directly modified, is modified so as to be widely and efficiently applied.
Osamu Mikami,Hiroyuki Yamaguchi,Hideo Murata,Yasuyuki Nakajima,Shigeru Miyazaki 대한수의학회 2010 Journal of Veterinary Science Vol.11 No.2
Six 1-month-old piglets were intravenously injected with deoxynivalenol (DON) at the concentration of 1 mg/kg body weight, with three pigs each necropsied at 6 and 24 h post-injection (PI) for investigation of hepatotoxicity and immunotoxicity with special attention to apoptotic changes and cytokine mRNA expression. Histopathological examination of the DON-injected pigs revealed systemic apoptosis of lymphocytes in lymphoid tissues and hepatocytes. Apoptosis of lymphocytes and hepatocytes was confirmed by the TdT-mediated dUTP-biotin nick end-labeling (TUNEL) method and immunohistochemical staining against singlestranded DNA and cleaved caspase-3. The number of TUNELpositive cells in the thymus and Peyer’s patches of the ileum was increased at 24 h PI compared to 6 h PI, but the peak was at 6 h PI in the liver. The mRNA expression of interleukin (IL)-1β, IL-6, IL-18, and tumor necrosis factor (TNF)-α in the spleen, thymus and mesenteric lymph nodes were determined by semi-quantitative RT-PCR, and elevated expression of IL-1β mRNA at 6 h PI and a decrease of IL-18 mRNA at 24 h PI were observed in the spleen. IL-1β and IL-6 mRNA expressions increased significantly at 6 h PI in the thymus, but TNF-α decreased at 6 h PI in the mesenteric lymph nodes. These results show the apoptosis of hepatocytes suggesting the hepatotoxic potential of DON, in addition to an immunotoxic effect on the modulation of proinflammatory cytokine genes in lymphoid organs with extensive apoptosis of lymphocytes induced by acute exposure to DON in pigs.
Development of Flight Simulator for Human-Powered Aircraft
Yasuhiro Inaba,Yuzo Shimada,Kenji Uchiyama,Kenichi Abe,Yoshio Ishikawa,Takao Sugimoto,Yasuyuki Miyazaki,Yuzo Koyama,Shohei Onishi,Kazuo Matubara,Chikatoshi Satoh,Takao Minejima,Kaname Hirayanagi,Michi 제어로봇시스템학회 2006 제어로봇시스템학회 국제학술대회 논문집 Vol.2006 No.10