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Women’s Dances from the Javanese Court
Michi Tomioka 국립민속박물관 2012 International Journal of Intangible Heritage Vol.7 No.-
Srimpi and bedhaya, danced by women at the Javanesecourt, developed into court rituals from the end of the 16thcentury. The choreography of these dances expressesideas like the peace and order of the cosmos, the unity ofgood and evil or of God and man. These dances were firstmade available to the general public through a nationalproject called the PKJT in 1970. This project did not justrevive the dances, it also shortened and adapted them fora modern audience in the belief that the traditional danceswere boring and monotonous. The new versions are widelyknown through recordings and are taught in art colleges. However, few dancers now know the original, full-lengthversions of the dances. I discuss how the meditativequality of these dances was lost when they were simplified. New ways of explaining the dances are now needed if theyare to be understood and appreciated by modernaudiences.
Michi, Richard A.,Kim, Gwansik,Kim, Byung-Wook,Lee, Wooyoung,Dunand, David C. Elsevier 2018 Scripta materialia Vol.148 No.-
<P><B>Abstract</B></P> <P>The compressive creep behavior of hot-pressed Mg<SUB>1.96</SUB>Al<SUB>0.04</SUB>Si<SUB>0.97</SUB>Bi<SUB>0.03</SUB>, a promising thermoelectric material, is investigated at 500 °C. At stress levels between 81 and 212 MPa, dislocation creep with stress exponent <I>n</I> = 7.6 ± 0.3 is observed. No diffusional creep is observed, likely attributable to a dispersion of ~1 μm Bi-, Al-, and O- rich particles which pin grain boundaries. Mg<SUB>1.96</SUB>Al<SUB>0.04</SUB>Si<SUB>0.97</SUB>Bi<SUB>0.03</SUB> exhibits similar creep behavior to previously studied silicides, but is significantly more creep resistant than other thermoelectric materials, PbTe and Bi<SUB>2</SUB>Te<SUB>3</SUB>. This makes Mg<SUB>1.96</SUB>Al<SUB>0.04</SUB>Si<SUB>0.97</SUB>Bi<SUB>0.03</SUB> an excellent material for thermoelectric power generation systems subjected to high stresses and temperatures.</P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>
Molecular targeted therapies for microscopic polyangiitis and granulomatosis with polyangiitis
Masayoshi Harigai,Michi Tsutsumino,Hideto Takada,Kenji Nagasaka 대한내과학회 2019 The Korean Journal of Internal Medicine Vol.34 No.3
Clinical trials and observational studies have established cyclophosphamide (CY) or rituximab plus glucocorticoid (GC) as standard remission induction therapies in patients with microscopic polyangiitis (MPA) and granulomatosis with polyangiitis (GPA). However, because these regimens are associated with serious adverse drug reactions, the development of drugs with novel mechanisms of actions are needed. Progress in basic and clinical research has identified novel candidate targeting molecules, including B-cell activating factor (BAF), C5a receptor, and interleukin-6. The combination of rituximab and BAF blockade in patients with MPA and GPA is under investigation in an effort to strike a better benefit-risk balance. Phase II clinical trials of avacopan (CCX168), an orally administered C5a receptor antagonist, have suggested a reduction in the dosage of concomitant GC or the replacement of GC in patients with MPA and GPA. The results from a currently ongoing phase III trial are awaited. Anecdotal case reports and an open-label pilot study have indicated the effectiveness of tocilizumab in patients with MPA and GPA. A randomized clinical trial comparing tocilizumab and intravenous CY in combination with GC is currently in progress. Molecular targeted therapy is expected to transform the treatment strategy for MPA and GPA to allow GC-free or at least less GC-dependent forms of therapy.
Hirofumi Yoshioka,Shuta Asai,Miki Yoshioka,Michie Kobayashi 한국분자세포생물학회 2009 Molecules and cells Vol.28 No.4
Rapid production of nitric oxide (NO) and reactive oxygen species (ROS) has been implicated in the regulation of innate immunity in plants. A potato calcium-dependent protein kinase (StCDPK5) activates an NADPH oxidase StRBOHA to D by direct phosphorylation of N-terminal regions, and heterologous expression of StCDPK5 and StRBOHs in Nicotiana benthamiana results in oxidative burst. The transgenic potato plants that carry a constitu-tively active StCDPK5 driven by a pathogen-inducible promoter of the potato showed high resistance to late blight pathogen Phytophthora infestans accompanied by HR-like cell death and H2O2 accumulation in the attacked cells. In contrast, these plants showed high susceptibility to early blight necrotrophic pathogen Alternaria solani, suggesting that oxidative burst confers high resistance to biotrophic pathogen, but high susceptibility to necrotro-phic pathogen. NO and ROS synergistically function in defense responses. Two MAPK cascades, MEK2-SIPK and cytokinesis-related MEK1-NTF6, are involved in the induc-tion of NbRBOHB gene in N. benthamiana. On the other hand, NO burst is regulated by the MEK2-SIPK cascade. Conditional activation of SIPK in potato plants induces oxidative and NO bursts, and confers resistance to both biotrophic and necrotrophic pathogens, indicating the plants may have obtained during evolution the signaling pathway which regulates both NO and ROS production to adapt to wide-spectrum pathogens.