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RISS 인기검색어
- 검색키워드
- 저자 : Yang Joo-Yoel (검색결과 2 건)
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Ahn, Jung-Mo,Sung, Hye-Jin,Yoon, Yeon-Hee,Kim, Byung-Gyu,Yang, Won Suk,Lee, Cheolju,Park, Hae-Min,Kim, Bum-Jin,Kim, Byung-Gee,Lee, Soo-Youn,An, Hyun-Joo,Cho, Je-Yoel The American Society for Biochemistry and Molecula 2014 Molecular & cellular proteomics Vol.13 No.1
<P>Small cell lung cancer (SCLC) is an aggressive type of lung cancer, and the detection of SCLCs at an early stage is necessary for successful therapy and for improving cancer survival rates. Fucosylation is one of the most common glycosylation-based modifications. Increased levels of fucosylation have been reported in a number of pathological conditions, including cancers. In this study, we aimed to identify and validate the aberrant and selective fucosylated glycoproteins in the sera of patients with SCLC. Fucosylated glycoproteins were enriched by the <I>Aleuria aurantia</I> lectin column after serum albumin and IgG depletion. In a narrowed down and comparative data analysis of both label-free proteomics and isobaric peptide-tagging chemistry iTRAQ approaches, the fucosylated glycoproteins were identified as up- or down-regulated in the sera of limited disease and extensive disease stage patients with SCLC. Verification was performed by multiple reaction monitoring-mass spectrometry to select reliable markers. Four fucosylated proteins, APCS, C9, SERPINA4, and PON1, were selected and subsequently validated by hybrid <I>A. aurantia</I> lectin ELISA (HLE) and Western blotting. Compared with Western blotting, the HLE analysis of these four proteins produced more optimal diagnostic values for SCLC. The PON1 protein levels were significantly reduced in the sera of patients with SCLC, whereas the fucosylation levels of PON1 were significantly increased. Fucosylated PON1 exhibited an area under curve of 0.91 for the extensive disease stage by HLE, whereas the PON1 protein levels produced an area under curve of 0.82 by Western blot. The glycan structural analysis of PON1 by MS/MS identified a biantennary fucosylated glycan modification consisting of a core + 2HexNAc + 1Fuc at increased levels in the sera of patients with SCLC. In addition, the PON1 levels were decreased in the sera of the Lewis lung carcinoma lung cancer mouse model that we examined. Our data suggest that fucosylated protein biomarkers, such as PON1, and their fucosylation levels and patterns can serve as diagnostic and prognostic serological markers for SCLC.</P>
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곽영길,최민수,배재훈,전인평,황광연,양주열,김도헌,강정완,Kwag Young-Kil,Choi Min-Su,Bae Jae-Hoon,Jeon In-Pyung,Hwang Kwang-Yun,Yang Joo-Yoel,Kim Do-Heon,Kang Jung-Wan 한국전자파학회 2006 한국전자파학회논문지 Vol.17 No.8
비행체 탑재 레이다는 민군 겸용으로 기상에 관계없이 전천후로 비행체의 안전 항행, 임무 감시, 사격 통제, 충돌 회피, 이착륙 등 비행에 필수적인 항공 전자 장치이다. 본 논문에서는 헬기 탑재 다중 모드 X-밴드 펄스 도플러 레이다 시험 모델의 설계, 제작 및 비행 시험 결과를 제시한다. 레이다 시스템은 안테나부, 송수신부, 신호처리부와 전시부의 4개의 LRU로 구성되며, 개발 기술은 평판 슬롯 배열 안테나, TWTA 송신기, coherent I/Q detector, 디지털 펄스 압축, MTI, DSP 기반 도플러 FFT 필터, 적응 CFAR, 도플러 추정보상 기법, 비행 안정화 및 TWS 추적 처리기를 포함한다. 개발된 레이다 시스템의 설계 성능은 다양한 지상 고정 및 이동 시험과 헬기 탑재 비행 시험을 통하여 이동 비행체 이동 클러터 보상과 MTD 성능을 확인하였다. An airborne radar is an essential aviation electronic system for the aircraft to perform various civil and/or military missions in all weather environments. This paper presents the design, development, and test results of the multi-mode X-band pulsed Doppler radar system test model for helicopter-borne flight test. This radar system consists of 4 LRUs(Line-Replacement Unit), which include antenna unit, transmitter and receiver unit, radar signal & data processing unit and display Unit. The developed core technologies include the planar array antenna, TWTA transmitter, coherent I/Q detector, digital pulse compression, MTI, DSP based Doppler FFT filter, adaptive CFAR, moving clutter compensation, platform motion stabilizer, and tracking capability. The design performance of the developed radar system is verified through various ground fixed and moving vehicle test as well as helicopter-borne field tests including MTD(Moving Target Detector) capability for the Doppler compensation due to the moving platform motion.
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