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      • Mechanical behaviour between adjacent cracks in CFRP plate reinforced RC slabs

        Xin Yuan,Hongyu Bai,Chen Sun,Qinqing Li,Yanfeng Song 국제구조공학회 2022 Structural Engineering and Mechanics, An Int'l Jou Vol.84 No.3

        This paper discussed and analyzed the interfacial stress distribution characteristic of adjacent cracks in Carbon Fiber Reinforced Polymer (CFRP) plate strengthened concrete slabs. One un-strengthened concrete test beam and four CFRP platestrengthened concrete test beams were designed to carry out four-point flexural tests. The test data shows that the interfacial shear stress between the interface of CFRP plate and concrete can effectively reduce the crack shrinkage of the tensile concrete and reduces the width of crack. The maximum main crack flexural height in pure bending section of the strengthened specimen is smaller than that of the un-strengthened specimen, the CFRP plate improves the rigidity of specimens without brittle failure. The average ultimate bearing capacity of the CFRP-strengthened specimens was increased by 64.3% compared to that without CFRP-strengthen. This indicites that CFRP enhancement measures can effectively improve the ultimate bearing capacity and delay the occurrence of debonding damage. Based on the derivation of mechanical analysis model, the calculation formula of interfacial shear stress between adjacent cracks is proposed. The distributions characteristics of interfacial shear stress between certain crack widths were given. In the intermediate cracking region of pure bending sections, the length of the interfacial softening near the mid-span cracking position gradually increases as the load increases. The CFRP-concrete interface debonding capacity with the larger adjacent crack spacing is lower than that with the smaller adjacent crack spacing. The theoretical calculation results of interfacial bonding shear stress between adjacent cracks have good agreement with the experimental results. The interfacial debonding failure between adjacent cracks in the intermediate cracking region was mainly caused by the root of the main crack. The larger the spacing between adjacent cracks exists, the easier the interfacial debonding failure occurs.

      • KCI등재

        Coherent Population Transfer in a Three-Level System Driven by Unmatched Gaussian Pulses

        Hong Guo,Dingan Han,Hong Jin Kong,Hui Sun,Xuzong Chen,Yanfeng Bai 한국물리학회 2004 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.45 No.2

        The population transfer in a three-level system driven by unmatched Gaussian pulses is investigated. A set of time-dependent density matrix equations is solved numerically using the rotating wave approximation, and the solution shows that the population of the atomic level depends strongly on the pulse widths of the applied probe and coupling pulses. If the parameters are chosen appropriately, population can be transferred almost completely to the target state, which interacts with the pulse with the smaller pulse width.

      • Method of Reconstruction Governs Iron Metabolism After Gastrectomy for Patients With Gastric Cancer

        Lee, Joong Ho,Hyung, Woo Jin,Kim, Hyoung-Il,Kim, Yoo-Min,Son, Taeil,Okumura, Naoki,Hu, Yanfeng,Kim, Choong-Bai,Noh, Sung Hoon by Lippincott Williams Wilkins. 2013 Annals of surgery Vol.258 No.6

        OBJECTIVE:: Anemia after gastrectomy is commonly neglected by clinicians despite being an important and frequent long-term metabolic sequela. We hypothesized that the incidence and timing of the occurrence of iron deficiency after gastrectomy is closely associated with the extent of gastrectomy and the reconstruction method, and we investigated the treatment outcomes of iron supplementation to understand iron metabolism and determine the optimal reconstruction method after gastrectomy. PATIENTS AND METHODS:: Using a prospective gastric cancer database, we identified 381 patients with early gastric cancer with complete hematologic parameters who underwent gastrectomy between January 2004 and May 2008. Kaplan-Meier methods, Cox regression, and logistic regression were used to evaluate the associations of the extent of gastrectomy and reconstruction method with iron metabolism. RESULTS:: The prevalence of iron deficiency 3 years after gastrectomy was 69.1%, and iron-deficiency anemia was observed in 31.0% of patients. Iron deficiency developed in 64.8% and 90.5% of patients after distal gastrectomy and total gastrectomy within 3 years after surgery (P < 0.0001), respectively. Iron deficiency was significantly more frequent in women than in men (P < 0.0001) and after gastrojejunostomy than after gastroduodenostomy (P < 0.0001). Serum ferritin levels were different according to the extent of gastrectomy and reconstruction method. The proportion of patients treated for iron-deficiency anemia was also significantly different according to the extent of gastrectomy (P = 0.020). CONCLUSIONS:: Iron deficiency occurs in most patients with gastric cancer after gastrectomy, and its incidence was different according to the extent of gastrectomy and reconstruction method. To improve iron metabolism after distal gastrectomy, gastroduodenostomy would be the method of reconstruction whenever possible.

      • EGF Reverses Multi-drug Resistance via the p-ERK Pathway in HepG2/ADM and SMMC7721/ADM Hepatocellular Carcinoma Models

        Yan, Feng,Bai, Li-Ping,Gao, Hua,Zhu, Chang-Ming,Lin, Li,Kang, Xiang-Peng Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.6

        Aim: To investigate signaling pathways for reversal of EGF-mediated multi-drug resistance (MDR) in hepatocellular carcinoma (HCC) models. Materials and Methods: HCC MDR cell strain HepG2/adriamycin (ADM) and SMMC7721/ADM models were established using a method of exposure to medium with ADM between low and high concentration with gradually increasing concentration. Drug sensitivity and reversal of multi-drug resistance by EGF were determined and the cell cycle distribution and apoptosis were analyzed by flow cytometry. Phosphorylation of ERK1, ERK2, ERK5 and expression of Bim were detected by Western blotting. Results: The results showed that HepG2/ADM and SMMC7721/ADM cells were resistant not only to ADM, but also to multiple anticancer drugs. When used alone, EGF had no anti-tumor activity in HepG2/ADM and SMMC7721/ADM cells in vitro, while it increased the cytotoxicity of ADM. EGF induced cell apoptosis and G0/G1 phase cell cycle arrest in HepG2/ADM And SMMC7721/ADM cells, while enhancing activity of p-ERKs and up-regulated expression of BimEL. Conclusions: EGF might enhance the chemosensitivity of HepG2/ADM and SMMC7721/ADM cells via up-regulating p-ERKs and BimEL protein.

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