Elevated Serum Galectin-1 and Galectin-3 Levels in Children With Specific Learning Disorder: A Case Control Study

Yaşar Tanır,Zeynep Nur Gülle,Gökçe Sultan Uncu,Adile Merve Baki,Pervin Vural,Nusret Soylu,Abdurrahman Cahid Örengül 대한신경정신의학회 2023 PSYCHIATRY INVESTIGATION Vol.20 No.7

Objective Specific learning disorder (SLD) is a neurodevelopmental disorder in which underlying pathogenesis and etiological factors are not fully understood. Neuroinflammatory response (measured with serum levels of galectin-1 and galectin-3), which is associated with learning and memory, may play an important role in the etiopathogenesis of SLD. Aim of the present study is to examine whether serum galectin-1 and galectin-3 levels are related to SLD.Methods The current study consisted of 42 treatment-naive children with SLD and 42 control subjects. All of the subjects were assessed using semi-structured psychiatric examination to diagnose SLD and exclude attention-deficit hyperactivity disorder. Serum galectin-1 and galectin-3 levels were measured via venous blood samples.Results The SLD and control group did not differ significantly in terms of age, sex, and body mass index (BMI). The SLD group had significantly higher serum levels of galectin-1 (8.78±2.97 vs. 7.40±2.03, p=0.019) and galectin-3 (1.86±0.93 vs. 1.32±0.69, p=0.003) than the control group when controlled for age, sex, and BMI.Conclusion Higher serum levels of galectin-1 and galectin-3 in children with SLD may indicate the role of neuroinflammatory response in the pathogenesis of SLD. Other mechanisms involving galectin-1 and galectin-3 related to learning may play a part in the etiology of SLD.

Torsion of circular open cross-section with corrugated inner and outer surface

Yaşar Pala,Abdullah Pala 국제구조공학회 2020 Structural Engineering and Mechanics, An Int'l Jou Vol.73 No.1

In this study, the problem of torsion of bars with open cross section surrounded by corrugated boundaries is analyzed. An approximate analytical solution is given using perturbation technique. First, the stress analysis for circular open cross-section for arbitrary opening angle is formulated and the problem is analytically solved. Second, the open cross-section with corrugated cross section is analyzed using perturbation method. First order contributions to the stresses and the torques have been added. The results have been exemplified and compared by considering special examples.

Migration of Rod into Retroperitoneal Region: A Case Report and Review of the Literature

Yaşar Bayri,Murat Sakir Eksi,Ramazan Doğrul,Demet Yalçinkaya Koç,Deniz Konya 대한척추신경외과학회 2014 Neurospine Vol.11 No.4

Spinal stabilization with fusion is the widely used method for traumatic or pathologic fracture of spine, spinal stenosis, and spondylolisthesis. Complications may emerge during or after the operations. Infection, hematoma and neurological deficits are early noticed findings. Screw and/or rod fractures present in long-term after surgery. Rod migration in out of the spinal column is a rare entity. A 67-year-old woman was visited our clinic for right leg pain. She had a previous spinal instrumentation surgery for spondylolisthesis in another center 6 years before. After radiological work-up, a distally migrated rod piece was observed in the retroperitoneal portion. The patient was operated for degenerative change; old instruments were replaced and extended to the L2 level with posterior spinal fusion. After the operation, her right leg pain improved. The asymptomatic migrated rod piece has regularly been followed clinically and radiologically, since then. Although it has rarely been reported, migration of the instrumentation material should be kept in mind. Spinal fixation without fusion makes the mechanical system vulnerable to motion effects of spine, especially in a degenerative and osteoporotic background. Long-term, even life-long follow-up is necessary for late term complications.

Thrust force modelling and surface roughness optimization in drilling of AA-7075: FEM and GRA

Nafiz Yaşar 대한기계학회 2019 JOURNAL OF MECHANICAL SCIENCE AND TECHNOLOGY Vol.33 No.10

AA7075 aluminum alloy attracts scientific interest to participate in production of crucial components in aerospace, construction and automotive domains. Specifically, final products need to display equal quality to ensure the basic standards of safety in the aircraft industry. Despite the high machinability of the AA7075 alloy, hole quality may vary according to tool geometry and drilling parameters. In this study, the effects of different feed rate levels and cutting speeds on the surface roughness (Ra) and thrust (Fz) were investigated. Drilling experiments were conducted with drills of three different quality and geometry. The effects of drilling variables on the surface roughness and the thrust force according to “the smaller-the better” approach of the gray relation analysis (GRA) method have been investigated. Consequently, the highest and lowest gray relations degrees obtained were 0.828 and 0.338, respectively. Numerical analyzes for thrust force were performed with the ThirdWave AdvantEdge simulation software based on the finite element method. We also outlined that there exists an average difference of 4.9 % between the experimental and simulation thrust force values, and we proved the applicability of the finite element model.

Estimating the Optimal Dexketoprofen Pharmaceutical Formulation with Machine Learning Methods and Statistical Approaches

Atakan Başkor,Yağmur Pirinçci Tok,Burcu Mesut,Yıldız Özsoy,Tamer Uçar 대한의료정보학회 2021 Healthcare Informatics Research Vol.27 No.4

Objectives: Orally disintegrating tablets (ODTs) can be utilized without any drinking water; this feature makes ODTs easy touse and suitable for specific groups of patients. Oral administration of drugs is the most commonly used route, and tabletsconstitute the most preferable pharmaceutical dosage form. However, the preparation of ODTs is costly and requires longtrials, which creates obstacles for dosage trials. The aim of this study was to identify the most appropriate formulation usingmachine learning (ML) models of ODT dexketoprofen formulations, with the goal of providing a cost-effective and timereducingsolution. Methods: This research utilized nonlinear regression models, including the k-nearest neighborhood (k-NN), support vector regression (SVR), classification and regression tree (CART), bootstrap aggregating (bagging), randomforest (RF), gradient boosting machine (GBM), and extreme gradient boosting (XGBoost) methods, as well as the t-test, topredict the quantity of various components in the dexketoprofen formulation within fixed criteria. Results: All the modelswere developed with Python libraries. The performance of the ML models was evaluated with R2 values and the root meansquare error. Hardness values of 0.99 and 2.88, friability values of 0.92 and 0.02, and disintegration time values of 0.97 and10.09 using the GBM algorithm gave the best results. Conclusions: In this study, we developed a computational approach toestimate the optimal pharmaceutical formulation of dexketoprofen. The results were evaluated by an expert, and it was foundthat they complied with Food and Drug Administration criteria.

Hypohidrotic Ectodermal Dysplasia Associated with Glucose-6-Phosphate Dehydrogenase Deficiency

Aylin Türel Ermertcan,Ali Yaşar,Tuba Çelebİ Kayhan,Hüseyin Gülen,Pelin Ertan 대한피부과학회 2011 Annals of Dermatology Vol.23 No.-

Hypohidrotic ectodermal dysplasia (HED) is a syndrome characterized by hypodontia, hypotrichosis, and partial or total ecrine sweat gland deficiency. The most prevalent form of HED is inherited as an X linked pattern. Glucose-6-phosphate dehydrogenase (G-6-PD) deficiency is an X-linked recessive disease, which leads to hemolytic anemia and jaundice. It is expressed in males, while heterozygous females are usually clinically normal. A 12-year-old boy with the complaints of hair and eyebrow disturbances, teeth disfigurement, decreased sweating, and xerosis presented to the outpatient clinic. Dermatological examination revealed sparse hair and eyebrows, conical- shaped teeth, xerosis,syndactylia, transverse grooves, and discoloration of nails. Laboratory findings indicated anemia. His 3-year-old sister also had sparse hair and eyebrows, xerosis, and syndactylia. We learned that the patient had a previous history of neonatal jaundice and a diagnosis of G-6-PD deficiency. Although it has been shown that loci of ectodermal dysplasia and G-6-PD deficiency genes are near to one another, we did not find any case study reporting on occurrence of these two genetic diseases together. With the aspect of this rare and interesting case, the relationship between HED and G-6-PD deficiency was defined. (Ann Dermatol 23(S1) S8∼S10,2011)

Investigation of the Mechanical, Electronic and Phonon Properties of X2ScAl (X = Ir, Os, and Pt) Heusler Compounds

Arikan Nihat,Ocak Hamza Yaşar,Dikici Yıldız Gökçen,Yıldız Yasin Göktürk,Ünal Rahmi 한국물리학회 2020 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.76 No.10

In the present study, the second-order elastic constants and the electronic band structures of the X2ScAl (x = Ir, Os, and Pt) compounds crystallized in the L21 phase were calculated separately by using the ab-initio density functional theory. According to the results for the second-order elastic constants, these compounds met the Born mechanical stability criteria. Also, according to the Pugh criteria, they were found to have a ductile structure and to show anisotropic behavior. The microhardneses of the compounds were between 2 and 14 GPa, and the highest hardness was found in the Ir2ScAl (14.290 GPa) compound. In addition, the energy band structures of these compounds were calculated, and the crystals were found to have a metallic bond structure. All the computed data were compared with previously calculated results obtained with different methods. According to the findings obtained in the present study, in terms of its mechanical and electronic behaviors, Ir2ScAl was found to have better physical properties than Os2ScAl and Pt2ScAl. The phonon dispersion curves and their corresponding total and projected densities of states were investigated for the first time by using a linear-response approach in the context of density functional perturbation theory. The frequencies of the optical phonon modes of all compounds at the Γ point were 4.767, 7.504 and 9.271 THz for Ir2ScAl, 2.761, 7.985 and 9.184 THz for Os2ScAl and 2.012, 5.6952 and 8.118 THz for Pt2ScAl. The heat capacity Cv at constant volume versus temperature was calculated using a quasi-harmonic approach and the results are discussed.

Comparison of Steroid Treatment with and without Hyperbaric Oxygen Therapy for Idiopathic Sudden Sensorineural Hearing Loss

Yücel Abitter,Özbuğday Yaşar 대한청각학회 2020 Journal of Audiology & Otology Vol.24 No.3

Background and Objectives: In this study, we compared the outcomes of patients with idiopathic sudden sensorineural hearing loss who underwent steroid treatment with or without hyperbaric oxygen (HBO) therapy and were followed-up in our clinic.Subjects and Methods: Patients were divided into two groups according to their treatment regimen. Steroid group received intravenous 1 mg/kg methylprednisolone which was due to be completed in 2-3 weeks with decreasing doses, and five doses of 0.5 mL intratympanic dexamethasone. Steroid+HBO group received the same steroid treatment with the addition of HBO therapy. The audiologic results of both treatment groups were compared after considering the patients’ risk factors.Results: There was no significant difference between the steroid and Steroid+HBO groups in terms of hearing gain and degree of recovery, both at all degrees of hearing loss, and in severe and profound hearing loss. Hearing gain was similar when evaluated by audiogram type and admission time in both treatment groups.Conclusions: We found that the addition of HBO therapy to systemic plus intratympanic steroid treatment did not affect hearing gain at all degrees of hearing loss in this study. Furthermore, audiogram type and admission time did not affect hearing gain between the two groups.

Anterior Segment Changes during Accommodation in Accommodative Esotropia

Mustafa Koç,Hakan Halit Yaşar,Mehmet Murat Uzel,Salih Çolak,Irfan Durukan,Pelin Yılmazbaş 대한안과학회 2018 Korean Journal of Ophthalmology Vol.32 No.1

To evaluate the anterior segment biometric parameters of non-accommodative and accommodativerefractive accommodative esotropia (RAE). Methods: Eighty-one eyes of 81 patients were included in this prospective, case-control study. The patientswere divided into three groups as follows: the RAE group (n = 31), the hypermetropia group (n = 25), and theemmetropia group (n = 25). Measurements were obtained in the non-accommodative (0.0 diopters) and accommodativestatus (-5.0 diopters) using a Pentacam HR. The anterior chamber depth (ACD), anterior chambervolume (ACV), pupil diameter (PD), and anterior chamber angle (ACA) were evaluated at all four quadrants. Results: The ACD, ACV and PD values in the RAE group were lower than those of the other groups in bothstates (p < 0.05). The ACD values were lower in the hypermetropia group than in the emmetropia group for thenon-accommodative status (p = 0.024) but were similar for the accommodative status (p = 0.225). PD and ACVvalues were lower in the hypermetropia group than in the emmetropia group in both states (non-accommodativestatus, p = 0.011 and p = 0.022; accommodative status, p = 0.026 and p = 0.034, respectively). Changes inACD, ACV and PD during accommodation (Δ) were not significant in the RAE group but were significant for theother groups (hypermetropia: ΔACD, p = 0.001; ΔACV, p = 0.001; ΔPD, p = 0.002; emmetropia: ΔACD, p < 0.001;ΔACV, p = 0.001; ΔPD, p < 0.001). These changes were significantly lower in the hypermetropia group than inthe emmetropia group (ΔACD, p = 0.012; ΔACV, p = 0.031; ΔPD, p = 0.034). Conclusions: The anterior chamber in RAE patients was shallower and the increase in convexity of the anteriorsurface or forward movement of the crystalline lens was more limited during accommodation in RAE.

LIGHTLIKE SUBMANIFOLDS OF A SEMI-RIEMANNIAN MANIFOLD WITH A SEMI-SYMMETRIC NON-METRIC CONNECTION

Ahmet Yücesan,Erol Yaşar 대한수학회 2010 대한수학회보 Vol.47 No.5

In this paper, we study lightlike submanifolds of a semi-Riemannian manifold admitting a semi-symmetric non-metric connection. We obtain a necessary and a sufficient condition for integrability of the screen distribution. Then we give the conditions under which the Ricci tensor of a lightlike submanifold with a semi-symmetric non-metric connection is symmetric. Finally, we show that the Ricci tensor of a lightlike submanifold of semi-Riemannian space form is not parallel with respect to the semi-symmetric non-metric connection.