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Synthesis and biological evaluation of the mimics of cis ligand for CD22
Yuki Sugamuna,Naoko Matsubara,Yuki Iwayama,Akiharu Ueki,Akihiro Imamura,Hiromune Ando,Takeshi Tsubata,Hideharu Ishida,Makoto Kiso 한국당과학회 2012 한국당과학회 학술대회 Vol.2012 No.1
CD22 (siglec-2) is an accessory molecule of the B-cell receptor complex (BCR) that exertsnegative effects on receptor signaling. It is also well-documented that CD22 is a regulatoryprotein that sets a threshold for immune responses. The carbohydrate ligand recognized byCD22 is the sequence Neuα(2,6)Galβ(1,4)GlcNAc found on both neighboringglycoconjugate of the same cell (cis ligand) and on other cells that interact with B cells (transligands). Recently, we have reported that the C-9 amido derivative of sialic acid (GSC718;9-(4’-hydroxy-4-biphenyl)acetamido-9-deoxy-Neu5Gc-OBn) show a potent affinity andselectivity for CD22 than other siglecs such as MAG [1]. Moreover, the compoundpromoted the proliferation of B cells in vitro. As next step of our investigation, we intend toreinforce the promoting activity of GSC718 for B cell growth by chemical modification.Herein, we report the efficient synthesis of GSC718 analogs which have varied aglyconmoieties. To achieve the comprehensive synthesis of GSC718 analogs having varied aglycons, wereexamined every synthetic process to obtain a fine target compound. In case of thesialoside synthesis, the most time-consuming and troublesome process is thechromatographic separation of α-sialoside from other byproducts such as β−isomer, 2,3-enederivative etc. after glycosylation reaction with aglycon part. To improve this process, weemployed 1,5-lactam formation as the key step for separation because the lactam formation isknown to proceed only in α-sialoside [2]. At the beginning of the synthesis of targetmolecules, we synthesized a suitably modified sialic acid donor in good yields. Then, thesialyl donor was reacted with various 2-substituted-ethanols to give the mixtures of α- and β-glycosides and 2,3-ene derivative, which were subsequently advanced to 1,5-lactamformation. As we anticipated, 1,5-lactamized α-sialosides became isolable from themixtures due to its different polarity from the other byproducts. Finally, the obtained 1,5-lactamized silaosides were successfully converted into target structures via reaction sequenceincluding C9-midification with biphenyl amide group, lactam opening and globaldeprotection. The synthesized analogs were advanced to biological assay using B cells. In this poster presentation, we will also discuss the structure-activity relationships of thesynthesized analogs. [1] H. H. M. Abdu-Allah et al, Bioorg. Med. Chem. Lett. 2011, 19, 1966-1971. [2] H. Tanaka et al, Tetrahedron Lett. 2009, 50, 4478-4481.
A Proposal of Refactoring toWell-StructuredWorkflow Nets
Yuki Kuroda,Shingo Yamaguchi,Minoru Tanaka 대한전자공학회 2009 ITC-CSCC :International Technical Conference on Ci Vol.2009 No.7
In this paper, we discuss refactoring free choice workflow nets (WF-net for short) to well-structured ones. It is known that most actual workflows can be modeled as free choice or well-strcutured WF-nets. There are more analysis methods for well-structured WF-nets. Refactoring free choice WF-nets to well-structured ones enables us to apply many analysis methods to free choice ones. We propose two rules for the refactoring. And we show an example of refactroing a WF-net, which represents the actual workflow for an travel agency.
Yuki Kato,Joverienne Chavez,Shin Yamada,Soichi Hattori,Shuzo Takazawa,Hiroshi Ohuchi 대한슬관절학회 2019 대한슬관절학회지 Vol.31 No.2
Purpose: This study aimed to investigate anterior knee symptoms in patients who underwent anterior cruciate ligament (ACL) reconstruction using bonepatellar tendonbone (BPTB) graft followed by implantation of a betatricalcium phosphate (βTCP) block as a bone void filler.Materials and Methods: We retrospectively reviewed 84 cases of synthetic bone grafting using a βTCP block for the patellar bone defect in ACL reconstruction with a BPTB autograft. Computed tomography of the operated knee was performed immediately after the surgery to evaluate whether the grafted βTCP block protruded forward from the anterior surface of the patella. On the basis of the results, the cases were divided into a protrusion group (n=31) and a nonprotrusion group (n=53). Anterior knee symptoms at 12 months postoperatively and absorption of the grafted βTCP block were compared between the two groups.Results: Except for patellofemoral crepitus, there was no significant difference in anterior knee symptoms between the two groups (p>0.05). The incidence of patellofemoral crepitus was significantly lower in the protrusion group than in the nonprotrusion group (p=0.027). The groups showed no significant difference in βTCP absorption.Conclusions: The present study demonstrated that the protrusion of βTCP that was used as a bone void filler had no adverse effects.
Yuki Tanisaka,Masafumi Mizuide,Akashi Fujita,Tomoya Ogawa,Hiromune Katsuda,Yoichi Saito,Kazuya Miyaguchi,Ryuhei Jinushi,Rie Terada,Yuya Nakano,Tomoaki Tashima,Yumi Mashimo,Shomei Ryozawa 소화기인터벤션의학회 2022 International journal of gastrointestinal interven Vol.11 No.1
Endoscopic retrograde cholangiopancreatography (ERCP) is the gold standard for diagnosis and intervention in patients with biliopancreatic disorders. However, ERCP in patients with surgically altered anatomy (SAA) is considered more difficult than in patients with normal anatomy. Since the introduction of balloon enteroscopes for patients with small intestine disorders, single-balloon enteroscopes (SBEs) and double-balloon enteroscopes (DBEs) have also been used for biliopancreatic diseases in patients with SAA. Nevertheless, the use of conventional SBEs and DBEs is limited, as a balloon enteroscope has a working length of 200 cm and a narrow working channel with a diameter of 2.8 mm; therefore, few ERCP accessories are available for use. A short-type SBE with a working length of 152 cm and a working channel of 3.2 mm in diameter, and a short-type DBE with a working length of 155 cm and a working channel of 3.2 mm were introduced to solve these difficulties. Favorable outcomes of these devices have recently been reported. Moreover, studies have reported several tips to achieve procedural success and factors affecting procedure failure. Difficult cases necessitate alternative techniques, such as percutaneous transhepatic biliary drainage and endoscopic ultrasound-guided biliary drainage.
An Evaluation of Burst Transfer Inferred by a High-level Synthesis Tool
Yuki Yamagata,Akira Yamawaki 대한전자공학회 2019 IEIE Transactions on Smart Processing & Computing Vol.8 No.2
High-level synthesis (HLS) is technology that automatically converts software to digital hardware. HLS has gained attention as a promising technology that can reduce the burden of hardware development. However, if a software program converted by HLS does not consider organization of the hardware, the current HLS technology cannot convert software to proper digital hardware. One of the characteristics of the hardware to be considered is burst transfer to memory access. Burst transfer attempts to speed up memory access by packing continuous data into a single address. This paper discusses a rectangle-drawing case study that demonstrates how to describe a C program so an HLS tool can infer burst transfer with an arbitrary burst length. Moreover, we consider the necessity to suppress optimization performed by the HLS tool to prevent increasing the amount of digital hardware when we implement the arbitrary burst length. Experiments clarify how performance and the hardware scale change based on the difference in the burst length and suppression of optimization.
Examination on Fatigue Limit and Crack Growth Characteristic of SBHS700 Base Metal
Yuki Ono,Koji Kinoshita 한국강구조학회 2018 International Journal of Steel Structures Vol.18 No.4
The object of this study is to clarify fatigue limit and fatigue crack growth characteristic of SBHS700 base metal which is 780 MPa class steel. This study carried out the fatigue tests of SBHS700 base metal containing diff erent defect size, and the fatigue limit was compared with that of the conventional steel. Test results indicate that the fatigue limit increased with decrease initial defect size, and can be precisely evaluated by using √area parameter model. This paper also presents that crack growth characteristic was almost the same as that of the conventional steel from the observation of striations by using Scanning electron microscope and length of beach marks.
Yuki Ichinose,Takafumi Nishimura,Minori Harada,Ryota Kashiwagi,Mikihiro Yamamoto,Yoshiteru Noutoshi,Kazuhiro Toyoda,Fumiko Taguchi,Daigo Takemoto,Hidenori Matsui 한국식물병리학회 2020 Plant Pathology Journal Vol.36 No.2
Pseudomonas syringae pv. tabaci 6605 has two mul- tidrug resistance (MDR) efflux pump transporters, MexAB-OprM and MexEF-OprN. To understand the role of these MDR efflux pumps in virulence, we generated deletion mutants, ∆mexB, ∆mexF, and ∆mexB∆mexF, and investigated their sensitivity to plant-derived antimicrobial compounds, antibiotics, and virulence. Growth inhibition assays with KB soft agar plate showed that growth of the wild-type (WT) was inhibited by 5 μl of 1 M catechol and 1 M coumarin but not by other plant-derived potential antimicrobial compounds tested including phytoalexins. The sensitiv- ity to these compounds tended to increase in ∆mexB and ∆mexB∆mexF mutants. The ∆mexB∆mexF mutant was also sensitive to 2 M acetovanillone. The mexAB- oprM was constitutively expressed, and activated in the ∆mexF and ∆mexB∆mexF mutant strains. The swarming and swimming motilities were impaired in ∆mexF and ∆mexB∆mexF mutants. The flood inocula- tion test indicated that bacterial populations in all mu- tant strains were significantly lower than that of WT, although all mutants and WT caused similar disease symptoms. These results indicate that MexAB-OprM extrudes plant-derived catechol, acetovanillone, or cou- marin, and contributes to bacterial virulence. Further- more, MexAB-OprM and MexEF-OprN complemented each other’s functions to some extent.
Design of Model Following Control Systems with Discrete-valued Signal Constraints
Yuki Minami 제어·로봇·시스템학회 2016 International Journal of Control, Automation, and Vol.14 No.1
This paper focuses on a design problem of model following control systems with discrete-valued inputconstraints. In the problem, we design a discrete-valued output controller such that the output behavior of thediscrete-valued input system is similar to that of a given reference model. In this paper, we first formulate thecontroller design problem, and then we analyze the performance of a class of controllers. Based on the result ofthe performance analysis, we analytically derive a controller characterized by the parameters of the plant and thereference model. Finally, we discuss a practical controller design problem considering the fixed-order, the stability,and the input-output gain constraints of controllers. The problem is solved by using a particle swarm optimizationalgorithm.