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        Preparation of Porous Ni–Cu Alloy Electrodes and their Electrocatalytic Performance as Cathode for Hydrogen Evolution Reaction in Alkaline Solution

        Li Yuan,Chen Gao,Chunyan Zeng,Yue Lu,Xuzheng Qian,Fuyi Chen 성균관대학교(자연과학캠퍼스) 성균나노과학기술원 2017 NANO Vol.12 No.10

        Porous Ni–Cu alloy electrodes were conveniently fabricated by galvanic displacement reaction (GDR) between Ni foam and copper ion in copper ion solutions, followed by cyclic voltammetry (CV) treatment to form a hierarchical microstructure. The electrocatalytic performance of prepared electrodes in terms of the hydrogen evolution reaction (HER) was investigated in a 1 mol/L KOH solution at room temperature. Different copper ion solutions were tested to determine the best copper ion solution and the optimum GDR time, and experimental results show that all cathodes obtained by GDR between Ni foam and copper ion exhibit a superior HER activity over the pure Ni foam cathode, while the HER activity of electrode obtained by GDR between Ni foam and copper ion in 0.5 mol/L CuCl2 solutions for 1 h is the highest. Furthermore, it is found that the HER activity of electrode obtained by GDR between Ni foam and copper ion in 0.5 mol/L CuCl2 solutions for 1 h can be further enhanced through a CV treatment and the optimal number of CV cycles is 3, which can be attributed to a hierarchical microstructure (a needle-like nano–microstructure formed on the surface of the electrode during the CV treatment process).

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        Active hexose correlated compound potentiates the antitumor effects of low-dose 5-fluorouracil through modulation of immune function in hepatoma 22 tumor-bearing mice

        Zhiyun Cao,Xuzheng Chen,Lan Lan,Zhideng Zhang,Jian Du,Lianming Liao 한국영양학회 2015 Nutrition Research and Practice Vol.9 No.2

        BACKGROUND/OBJECTIVES: A variety of immunomodulators can improve the efficacy of low-dose chemotherapeutics. Active hexose correlated compound (AHCC), a mushroom mycelia extract, has been shown to be a strong immunomodulator. Whether AHCC could enhance the antitumor effect of low-dose 5-fluorouracil (5-FU) via regulation of host immunity is unknown. MATERIALS/METHODS: In the current study Hepatoma 22 (H22) tumor-bearing mice were treated with PBS, 5-FU (10 mg?kg<SUP>-1</SUP>?d<SUP>-1</SUP>, i.p), or AHCC (360 mg?kg<SUP>-1</SUP>?d<SUP>-1</SUP>, i.g) plus 5-FU, respectively, for 5 d. CD3<SUP>+</SUP>, CD4<SUP>+</SUP>, CD8<SUP>+</SUP>, and NK in peripheral blood were detected by flow cytometry. ALT, AST, BUN, and Cr levels were measured by biochemical assay. IL-2 and TNFα in serum were measured using the RIA kit and apoptosis of tumor was detected by TUNEL staining. Bax, Bcl-2, and TS protein levels were measured by immunohistochemical staining and mRNA level was evaluated by RT-PCR. RESULTS: Diet consumption and body weight showed that AHCC had no apparent toxicity. AHCC could reverse liver injury and myelosuppression induced by 5-FU (P < 0.05). Compared to mice treated with 5-FU, mice treated with AHCC plus 5-FU had higher thymus index, percentages of CD3<SUP>+</SUP>, CD4<SUP>+</SUP>, and NK cells (P < 0.01), and ratio of CD4<SUP>+</SUP>/CD8<SUP>+</SUP> (P < 0.01) in peripheral blood. Radioimmunoassay showed that mice treated with AHCC plus 5-FU had the highest serum levels of IL-2 and TNFα compared with the vehicle group and 5-FU group. More importantly, the combination of AHCC and 5-FU produced a more potent antitumor effect (P < 0.05) and caused more severe apoptosis in tumor tissue (P < 0.05) compared with the 5-FU group. In addition, the combination of AHCC and 5-FU further up-regulated the expression of Bcl-2 associated X protein (Bax) (P< 0.01), while it down-regulated the expression of B cell lymphoma 2 (Bcl-2) (P < 0.01). CONCLUSIONS: These results support the claim that AHCC might be beneficial for cancer patients receiving chemotherapy.

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        Sensing formic acid with a water-based chitosan lanthanide luminescence film

        Xu Zheng,Xi Chen,Xudong Yu,Yifan Yang 한국공업화학회 2023 Journal of Industrial and Engineering Chemistry Vol.125 No.-

        A sensitive and selective formic acid sensor could be useful in detecting this corrosive acid in industrial,medical, and environmental settings. Herein, we present a film for detection of formic acid. We introducedchitosan as a film-forming factor to creatively overcome the problem that chitosan dissolves inacids. A carboxylic acid-carbon dot solution was used to replace the strong acid solution and prepare aluminescent film in which the color changed from green to blue when it was exposed to formic acid. Integrated data analysis of the film was used to distinguish vapor from formic acid/water solutions at differentconcentrations and with a detection limit of 0.01% v/v. The selectivity of the sensor was also investigated. After fumigation with ethanol and other common solvents, there was no response similar to thatfor formic acid. It is believed that films based on lanthanide complexes and chitosan could prevent corrosionand injury from formic acid.

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