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- 저자 : Xuewen CAO (검색결과 3 건)
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Teng WANG,Zhaofu MENG,Xinxin WANG,Amjad ALI,Xuewen CAO,Lin LIU 대한환경공학회 2021 Environmental Engineering Research Vol.26 No.6
N-doped and N-F co-doped TiO2/bentonite composites were synthesized via the gel-sol method. The morphology, structure and surface charge of the composite before and after adsorption were used to determine the effect N/F doping ratio on TC removal. The results showed that, compared with undoped samples, the TC adsorption on N doped composites was reduced by 24.44% on average. N-F co-doping significantly increased the TC adsorption when the Ti-N-F molar ratio was 1:1: 0.01, reaching a maximum TC adsorption of 64.00 mmol·kg−1. The coverage of the N doped TiO2 increases as the N doping ratio increases; the specific surface area increased by 2.03 % on average, but the number of surface negative charges decreased by 36.24 % on average. FT-IR results confirmed that N doping reduced the number of -OH groups on the N-doped composites. Additionally, fluorination of N-F co-doped TiO2 and bentonite surfaces inhibits hydrogen bonding and π-π interactions between the TC and the composites. As the N doping ratio increased, the coverage of N-F co-doped TiO2 on the composite surface increased, resulting in the TC adsorption decrease with the increases N doping ratio.
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Teng WANG,Zhaofu MENG,Xinxin WANG,Amjad ALI,Xuewen CAO,Lin LIU 대한환경공학회 2021 Environmental Engineering Research Vol.26 No.6
N-doped and N-F co-doped TiO₂/bentonite composites were synthesized via the gel-sol method. The morphology, structure and surface charge of the composite before and after adsorption were used to determine the effect N/F doping ratio on TC removal. The results showed that, compared with undoped samples, the TC adsorption on N doped composites was reduced by 24.44% on average. N-F co-doping significantly increased the TC adsorption when the Ti-N-F molar ratio was 1:1: 0.01, reaching a maximum TC adsorption of 64.00 mmol·kg<SUP>-1</SUP>. The coverage of the N doped TiO₂ increases as the N doping ratio increases; the specific surface area increased by 2.03 % on average, but the number of surface negative charges decreased by 36.24 % on average. FT-IR results confirmed that N doping reduced the number of -OH groups on the N-doped composites. Additionally, fluorination of N-F co-doped TiO₂ and bentonite surfaces inhibits hydrogen bonding and π-π interactions between the TC and the composites. As the N doping ratio increased, the coverage of N-F co-doped TiO₂ on the composite surface increased, resulting in the TC adsorption decrease with the increases N doping ratio.
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Chunping Yu,Yi Zhang,Ning Wang,Wensu Wei,Ke Cao,Qun Zhang,Peiying Ma,Dan Xie,Pei Wu,Biao Liu,Jiahao Liu,Wei Xiang,Xing Hu,Xuewen Liu,Jianfei Xie,Jin Tang,Zhi Long,Long Wang,Hongliang Zeng,Jianye Liu 한국생체재료학회 2022 생체재료학회지 Vol.26 No.1
Background: Circular RNAs (circRNAs) have important functions in many fields of cancer biology. In particular, we previously reported that the oncogenic circRNA, circPRMT5, has a major role in bladder cancer progression. Therapy based on circRNAs have good prospects as anticancer strategies. While anti-circRNAs are emerging as therapeutics, the specific in vivo delivery of anti-circRNAs into cancer cells has not been reported and remains challenging. Methods: Synthesized chrysotile nanotubes (SCNTs) with a relatively uniform length (~ 200 nm) have been designed to deliver an siRNA against the oncogenic circPRMT5 (si-circPRMT5) inhibit circPRMT5. In addition, the antitumor effects and safety evaluation of SCNTs/si-circPRMT5 was assessed with a series of in vitro and in vivo assays. Results: The results showed that SCNTs/si-circPRMT5 nanomaterials prolong si-circPRMT5’s half-life in circulation, enhance its specific uptake by tumor cells, and maximize the silencing efficiency of circPRMT5. In vitro, SCNTs encapsulating si-circPRMT5 could inhibit bladder cancer cell growth and progression. In vivo, SCNTs/si-circPRMT5 inhibited growth and metastasis in three bladder tumor models (a subcutaneous model, a tail vein injection lung metastatic model, and an in situ model) without obvious toxicities. Mechanistic study showed that SCNTs/sicircPRMT5 regulated the miR-30c/SNAIL1/E-adherin axis, inhibiting bladder cancer growth and progression. Conclusion: The results highlight the potential therapeutic utility of SCNTs/si-circPRMT5 to deliver si-circPRMT5 to treat bladder cancer.
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