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Metastasis associated genomic aberrations in stage II rectal cancer
Hong Zhao,Zhi-Zhou Shi,Rui Jiang,Dong-Bing Zhao,Hai-Tao Zhou,Jian-Wei Liang,Xin-Yu Bi,Jian-Jun Zhao,Zhi-Yu Li,Jian-Guo Zhou,Zhen Huang,Ye-Fan Zhang,Jian Wang,Xin Xu,Yan Cai,Ming-Rong Wang,Yu Zhang 한국유전학회 2016 Genes & Genomics Vol.38 No.11
Genomic aberrations of rectal carcinoma, especially DNA copy number changes associated with metastasis were largely unclear. We aim to identify the metastasis associated biomarkers in stage II rectal cancer. Formalin-fixed, paraffin-embedded primary tumor tissues of stage II rectal carcinoma were analyzed by array-based comparative genomic hybridization, and genomic aberrations were identified by Genomic Workbench and SAM software. Copy number changes and mRNA expressions were validated by Real-time PCR in an independent rectal cancer samples. The results showed that the most frequent gains in stage II rectal cancer were at 1q21.2-q23.1, 3p21.31, 11q12.2-q23.3, 12q24.11-q24.31, 12q13.11-q14.1 and losses in 18q11.2-q23, 17q21.33-q22, 13q31.1-q31.3, 21q21.1-q21.3, 8p23.3-p23.1 and 4q22.1-q23. Twenty-two amplifications and five homozygous deletions were also identified. We further found that S100A1 (1q21.3-q23.1), MCM7 (7q22.1) and JUND (19p13.11) were amplified and overexpressed in stage II rectal cancer. Interestingly, the genomic aberrations affected 14 signaling pathways including VEGF signaling pathway and fatty acid metabolism. Most importantly, loss of 13q31.1-q34 and gain of 1q44 were associated with distant metastasis. Our results indicated that these metastasis associated genomic changes may be useful to reveal the pathogenesis of rectal cancer metastasis and identify candidate biomarkers.
Rui-Hua Wang,Bing-Xin Xue,Jing-Bo Zhao 제어·로봇·시스템학회 2019 International Journal of Control, Automation, and Vol.17 No.8
The problem of H∞ control for discrete-time switched systems is investigated via admissible edgedependent average dwell time (AED-ADT) method in this paper. By virtue of a convex combination of positive definite matrices, a novel multiple piecewise convex Lyapunov function (MPCLF) is designed, which can relax the restricted conditions of Lyapunov functions at switching points and interval interior points. Based on the MPCLF approach, the time-varying H∞ state feedback controllers, guaranteeing that the corresponding closed-loop system is globally uniformly exponentially stable (GUES) with a prescribed H∞ performance, are established for the considered switched system. Finally, three numerical examples are provided to illustrate the effectiveness of the proposed approaches.
Xin Wu,Yibing Liu,Rui Liu,Li Zhao 대한기계학회 2016 JOURNAL OF MECHANICAL SCIENCE AND TECHNOLOGY Vol.30 No.4
The occurrence of surge in a centrifugal compressor results in large oscillations in pressure and flow. To avoid damaging the compressor because of surge, we develop several surge detection methods in this study. Considering the incipient surge phenomenon, the Empirical mode decomposition (EMD) and the Morlet Continuous wavelet transform (CWT) methods are selected. Both methods are validated through experimental data collected from surge tests conducted on the three-stage Ingersoll-Rand Centac centrifugal compressor at Toyota Motor Manufacturing in Kentucky, USA. For incipient surge detection, the EMD-based method can determine the threshold 1 sec earlier than the Morlet CWT-based method. Therefore, the EMD method can be used to implement the incipient surge detection scheme on the tested centrifugal compressor for safety considerations.
Wang Xin,Liu Qian,Wan Yunbao,Cao Chenxi,Bai Jiuyuan,Wang Rui,Zhao Yun 한국응용생명화학회 2021 Applied Biological Chemistry (Appl Biol Chem) Vol.64 No.2
The farmland polluted by cadmium is increasing drastically, which seriously threatened agricultural production and food safety. Nowadays, efficient and convenient way to solve the problem is urgently needed. In this experiment, a particular compound passivator DHJ-C was applied for soil remediation by pot experiment and the effect on both soil and plant was evaluated. The DHJ-C reduced the toxicity of Cd on soil enzyme activity and growth inhibition on Brassica napus. The soil urease and sucrase activity were significantly increased. The dry weight of mature oilseed rape increased by 14.6–36.0% and the yield of seeds increased by 14.1–52% per plant, which suggested that the passivator effectively reduced the detrimental effects on rape. Similarly, the results of physiology and biochemistry also indicated that DHJ-C can distinctly alleviate the inhibitory effect of Cd on plant growth. Such as the MDA content in plant was reduced by 52.1% in 10 mg/kg Cd treatment. Compared with control, Cd accumulation in seedling stage and mature period was significantly reduced as the concentration of Cd in aboveground part even decreased by 18.4 and 32.0% respectively. Overall, DHJ-C hold sufficient ability to be applied as an excellent passivator to reduce Cd toxicity in contaminated soil and significantly increase the yield of rapeseed.
Meng Zhao,Gui-Xin Wang,Xiu-Li Li,Rui Liu,Kang-Ping Yan 대한금속·재료학회 2010 METALS AND MATERIALS International Vol.16 No.6
Microscale Fe-P alloy was prepared using Ca3(PO4)2 and Fe2O3 in an electrothermal reduction process, and the electrochemical performance was investigated in detail. The initial discharge capacity could reach ~566.8mAh/g at 0.3 C rate, and the fade trend was so slight that the normalized capacities from 1.0 to 2.0 C rate were adjacent. The energy density and the power density could reach ~1133.6 Wh/kg and ~912.4 W/kg,respectively. The rate capability and the cycle performance were comparable to those of the Fe-P alloy synthesized using zerovalent iron and phosphorus. At 0.5 mV/s scan rate, the oxidation peak and the reduction peak for the reaction of lithium ions with P were positioned at ~1.3 and ~0.5 V, respectively. The reaction occurred under diffusion control, and the lithium ion diffusion efficient was ~1.5×10−9 cm2/s.
hARIP2 is a Putative Growth-promoting Factor Involved in Human Colon Tumorigenesis
Gao, Rui-Feng,Li, Zhan-Dong,Jiang, Jing,Yang, Li-Hua,Zhu, Ke-Tong,Lin, Rui-Xin,Li, Hao,Zhao, Quan,Zhang, Nai-Sheng Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.20
Activin is a multifunctional growth and differentiation factor of the growth factor-beta (TGF-${\beta}$) superfamily, which inhibits the proliferation of colon cancer cells. It induces phosphorylation of intracellular signaling molecules (Smads) by interacting with its type I and type II receptors. Previous studies showed that human activin receptor-interacting protein 2 (hARIP2) can reduce activin signaling by interacting with activin type II receptors; however, the activity of hARIP2 in colon cancer has yet to be detailed. In vitro, overexpression of hARIP2 reduced activin-induced transcriptional activity and enhanced cell proliferation and colony formation in human colon cancer HCT8 cells and SW620 cells. Also, hARIP2 promoted colon cancer cell apoptosis, suggesting that a vital role in the initial stage of colon carcinogenesis. In vivo, immunohistochemistry revealed that hARIP2 was expressed more frequently and much more intensely in malignant colon tissues than in controls. These results indicate that hARIP2 is involved in human colon tumorigenesis and could be a predictive maker for colon carcinoma aggressiveness.