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Hongge Yan,Xiaole Gong,Jihua Chen,Meixin Cheng 대한금속·재료학회 2021 METALS AND MATERIALS International Vol.27 No.7
Microstructure, texture characteristics, mechanical and bio-corrosion properties of the Mg–5Zn–xSr alloys (x=0, 0.2, 0.6,1.0) prepared by high strain rate rolling are carefully studied. A low level of Sr addition enhances dynamic precipitationof nano-scale MgZn2 particles in the as-rolled Mg–5Zn alloy, with 0.6%Sr showing the maximum efciency. These highdensity MgZn2 particles can pin grain boundaries of dynamic recrystallization grains and inhibit their growth. A low levelof Sr addition (≤0.6%) enhances the (0002) basal texture, but 1.0%Sr is just the reverse. The as-rolled Mg–5Zn–0.6Sr alloyexhibits the best combination of ultimate tensile strength (359 MPa) and elongation to rupture (20%). The high strength canbe attributable to a reduced grain size, precipitation and basal texture strengthening. The Mg–5Zn–xSr alloys exhibit excellent bio-corrosion resistance, but a minor Sr addition cannot bring about further bio-corrosion resistance improvement dueto the multiple actions of grain size, DRX degree, dynamic precipitates and texture characteristics. The 0.6%Sr addition cangreatly improve the strength of the as-rolled alloy at no expense of bio-corrosion resistance.
Increase in Hypotonic Stress-Induced Endocytic Activity in Macrophages via ClC-3
Yan, Yutao,Ding, Yu,Ming, Bingxia,Du, Wenjiao,Kong, Xiaoling,Tian, Li,Zheng, Fang,Fang, Min,Tan, Zheng,Gong, Feili Korean Society for Molecular and Cellular Biology 2014 Molecules and cells Vol.37 No.5
Extracellular hypotonic stress can affect cellular function. Whether and how hypotonicity affects immune cell function remains to be elucidated. Macrophages are immune cells that play key roles in adaptive and innate in immune reactions. The purpose of this study was to investigate the role and underlying mechanism of hypotonic stress in the function of bone marrow-derived macrophages (BMDMs). Hypotonic stress increased endocytic activity in BMDMs, but there was no significant change in the expression of CD80, CD86, and MHC class II molecules, nor in the secretion of TNF-${\alpha}$ or IL-10 by BMDMs. Furthermore, the enhanced endocytic activity of BMDMs triggered by hypotonic stress was significantly inhibited by chloride channel-3 (ClC-3) siRNA. Our findings suggest that hypotonic stress can induce endocytosis in BMDMs and that ClC-3 plays a central role in the endocytic process.
Increase in Hypotonic Stress-Induced Endocytic Activity in Macrophages via ClC-3
Yutao Yan,Yu Ding,Bingxia Ming,Wenjiao Du,Xiaoling Kong,Li Tian,Fang Zheng,Min Fang,Zheng Tan,Feili Gong 한국분자세포생물학회 2014 Molecules and cells Vol.37 No.5
Extracellular hypotonic stress can affect cellular function. Whether and how hypotonicity affects immune cell function remains to be elucidated. Macrophages are immune cells that play key roles in adaptive and innate in immune reactions. The purpose of this study was to investigate the role and underlying mechanism of hypotonic stress in the function of bone marrow-derived macrophages (BMDMs). Hypotonic stress increased endocytic activity in BMDMs, but there was no significant change in the expression of CD80, CD86, and MHC class II molecules, nor in the secretion of TNF- or IL-10 by BMDMs. Furthermore, the enhanced endocytic activity of BMDMs triggered by hypotonic stress was significantly inhibited by chloride channel-3 (ClC-3) siRNA. Our findings suggest that hypotonic stress can induce endocytosis in BMDMs and that ClC-3 plays a central role in the endocytic process.