Effect of Aspirin on the Expression of Hepatocyte NF-κB and Serum TNF-α in Streptozotocin-Induced Type 2 Diabetic Rats

Xiaodong Sun,Fang Han,Junling Yi,Lina Han,Ben Wang 대한의학회 2011 Journal of Korean medical science Vol.26 No.6

Aspirin is a kind of anti-inflammatory drug and may be used to reverse hyperglycemia,hyperinsulinemia, and dyslipidemia by improving insulin resistance. We hypothesized that aspirin improves insulin resistance in type 2 diabetes by inhibiting hepatic nuclear factor kappa-β (NF-κB) activation and serum tumor necrosis factor-α (TNF-α). Adult male Wistar rats were randomly divided into four groups: control, untreated diabetic, diabetic treated with metformin (100 mg /kg/day), and diabetic treated with aspirin (120 mg/kg/day). Diabetes was induced by high-fat feeding and a low dose of streptozotocin (30 mg/kg). After treatment, plasma glucose, insulin, lipids, free fatty acids (FFAs) concentrations and serum TNF-α were determined. The expression of NF-κB in hepatocytes was analyzed by immunohistochemistry and western blot. The results showed administration of aspirin caused no significant lowering in fasting glucose level but significant reduction of hepatic NF-κB expression and serum TNF-α level with improved insulin resistance compared to the diabetic group. The relevant analysis showed positive correlation between the expression of homeostasis model assessment-insulin resistance (HOMA-IR) and NF-κB (r = 0.799, P <0.01); HOMA-IR and serum TNF-α (r = 0.790, P < 0.01). It is concluded that aspirin improves insulin resistance by inhibiting hepatic NF-κB activation and TNF-α level in streptozotocin-induced type 2 diabetic rats.

EXPERIMENTAL NANOMECHANICS OF ONE-DIMENSIONAL NANOMATERIALS BY IN SITU MICROSCOPY

XIAODONG HAN,ZE ZHANG,ZHONG LIN WANG 성균관대학교(자연과학캠퍼스) 성균나노과학기술원 2007 NANO Vol.2 No.5

This paper provides a comprehensive review on the methodological development and technical applications of in situ microscopy, including transmission electron microscopy (TEM), scanning electron microscopy (SEM) and atomic force microscopy (AFM), developed in the last decade for investigating the structure-mechanical-property relationship of a single one-dimensional nanomaterial, such as nanotube, nanowire and nanobelt. The paper covers both the fundamental methods and detailed applications, including AFM-based static elastic and plastic measurements of a carbon nanotube, external field-induced resonance dynamic measurement of elastic modulus of a nanotube/nanowire, nano-indentation, and in situ plastic deformation process of a nanowire. Details are presented on the elastic property measurements and direct imaging of plastic to superplastic behavior of semiconductor nanowires at atomic resolution, providing quantitative information on the mechanical behavior of nanomaterials. The studies on the Si and SiC nanowires clearly demonstrated their distinct, "unexpected" and superior plastic mechanical properties. Finally, a perspective is given on the future of nanomechanics.

Design and Analysis of a Novel 16/10 Segmented Rotor SRM for 60V Belt-Driven Starter Generator

Xiaodong Sun,Zhengwang Xue,Shouyi Han,Xing Xu,Zebin Yang,Long Chen 한국자기학회 2016 Journal of Magnetics Vol.21 No.3

This paper proposes a novel 16/10 segmented rotor switched reluctance motor (SSRM) for belt-driven starter generators (BSGs). Different from conventional SRMs, the stator of the proposed SSRM consists of two types of stator poles, i.e., exciting and auxiliary poles, and the rotor is constructed from a series of discrete segments. The topology and operation principle of this proposed SSRM are illustrated firstly, and then the design rules are listed. In addition, the finite element method (FEM) is employed to get the static and dynamic characteristics of the proposed SSRM. Finally, the simulation results are presented to show the validity of the proposed SSRM for BSGs.

Forest biomass carbon accumulation in Korea from 1954 to 2007

Li, Xiaodong,Yi, Myong Jong,Son, Yowhan,Jin, Guangze,Han, Sang Sub Informa UK (TaylorFrancis) 2010 Scandinavian journal of forest research Vol.25 No.6

Estimation of Carbon Storage Using Mean Biomass Density in Korean Forests

Li, Xiaodong,Yi, Myong-Jong,Jeong, Mi-Jeong,Son, Yo-Whan,Jin, Guangze,Han, Sang-Sub Korean Society of Forest Science 2010 한국산림과학회지 Vol.99 No.5

This study examined the biomass data estimated from different allometric models and calculated the mean aboveground biomass, mean belowground biomass and root/shoot ratio values according to the forest types and age classes. These mean values and the forest inventories in 2009 were used to estimate the aboveground and total biomass carbon storage in different forest types (coniferous, deciduous and mixed forests). The aboveground and total biomass carbon storage for all forest types in Korea were 350.201 Tg C and 436.724 Tg C. Over the past 36 years, plantations by reforestation programs have accounted for more than 70% of the observed carbon storage. The carbon storage in Korean forest biomass was 436.724 Tg C, of which 175.154 Tg C for coniferous forests, 126.772 Tg C for deciduous forests and 134.518 Tg C for mixed forests, comprising approximately 1/20 of the total carbon storage of the East Asian countries. The total carbon storage for the whole forest sector in Korea was 1213.122 Tg C, of which 436.724 Tg C is stored in forest biomass if using the ratio of carbon storage in different pools examined from the United States. Such large carbon storage in Korean forests is due mainly to active plantations growth and management practices.

중국 전지공예(剪紙) 기법 분석 기준에 따른 현대 패션디자인의 사례 연구 - 2015 S/S ~2019 S/S 컬렉션을 중심으로 -

순샤오동 ( Sun Xiaodong ),윤지영 ( Youn Ji-young ),한정민 ( Han Jung-min ),최수아 ( Choi Soo-ah ) 커뮤니케이션디자인학회(구 시각디자인학회) 2019 커뮤니케이션 디자인학연구 Vol.69 No.-

본 연구는 중국 전통 전지공예 기법에 대한 고찰과 이를 바탕으로 현대 패션에 표현된 사례를 전지공예 기법의 고유 특성에 따라 분석하고자 했다. 서적과 선행 연구를 통해 중국 전통 전지공예 기법을 분석한 후, 현대 사례로는 vogue.com의 최근 5년 컬렉션 자료를 사적 고찰하여 분석하였다. 연구 분석 결과, 첫째, 전통 전지공예 표현기법의 단색전지는 양·음각을 주기법으로하며 현대 패션에서 세밀한 강약 대비효과를 표현하였다. 이를 통해 현대 패션디자인의 예술적이면서 세밀한 장식적인 효과를 전달할 수 있다. 둘째, 현대 패션 디자인에 나타난 디자인 사례를 전통 전지공예 기법의 기준에 따라 분석하였고 그에 따른 대표적 미적가치를 찾을 수 있다. 셋째, 전통 전지 공예 기법 분석과 현대 패션디자인 적용 사례 분석을 통해 다양한 분야에 종사자들에게 창의적이고 무한한 활용 가능성을 제공할 것이다. In this study, we inspected the Chinese traditional paper cutting methods than based on the findings, the techniques and forms of shape of modern fashion were analysed, then analyzed their characteristics. The tradition paper cutting methodology was studied from books, and earlier studies, the case studies of modern fashion were collected from last five collections viewed from the webpage-vogue.com. The results of this study are as a following: firstly, Yin and Yang carving of monochrome paper cutting technique was often used to express the delicate contrast beauty in modern fashion designs. They were be able to convey artistic and decorative effect of Modern fashion design. Secondly, we found out the own aesthetic values from modern fashion design cases which were analysed by the Chinese paper cutting methodologies. Thirdly, Chinese paper cutting provided unlimited creativities and possibilities. Therefore, this study can provide a solid foundation to inherit the technique and multidirectional developments in various design fields in the future.

Characterization of Nano Sized Microstructures in Fe and Ni Base ODS Alloys Using Small Angle Neutron Scattering

Young-Soo Han,Jin-Sung Jang,Xiaodong Mao 한국유체기계학회 2016 유체기계 연구개발 발표회 논문집 Vol.2016 No.11

Failure analysis for hoisting wire ropes with local accumulated broken wire damage on the surface

Ping Zhou,Gongbo Zhou,Lianfeng Han,Xiaodong Yan,Hanyu Wang,Zhenzhi He 대한기계학회 2023 JOURNAL OF MECHANICAL SCIENCE AND TECHNOLOGY Vol.37 No.7

Surface broken wire (BW) damage to hoisting steel wire ropes (SWR) is unavoidable during the service process, and it continues to accumulate locally during the evolution process. The specific influence analysis of the surface damage with local cumulative BWs on the performance of the hoisting SWR is insufficient at present, which seriously affects the safety of the rope system. In this paper, a failure analysis method for the state of surface cumulative BW rope based on the integration of finite element (FE) and mechanical tension is proposed. First, a method for creating an FE model of surface BW damage is presented, and the stress-strain distribution features of damaged section under tensile load are revealed. Then, the residual mechanical strength of SWR under local cumulative BW damage is determined by performing a tensile test. Finally, based on the analysis of FE and breaking behavior, combined with the regulations, the state of the damaged SWR is comprehensively evaluated. The results show that the breaking position of the SWR under mechanical tension is the maximum stress distribution in the simulation analysis, which verifies the consistency between the simulation and the experiment; and the accumulation degree and distribution of local BW affect the residual mechanical strength of the SWR. This method explores the influence of different degrees of local BW damage on the mechanical properties of the SWR, which provides a direct basis for the non-destructive evaluation of the SWR state.