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심성웅(Sung-Woong Shim),김철환(Chul-Hwan Kim),이지영(Ji-Young Lee),M.I. Sheikh,박현진(Hyeon-Jin Park),김성호(Sung-Ho Kim),김경철(Keoung-Chul Kim),조후승(Hoo-Seoung Jo),주종훈(Jong-Hun Joo),김중호(Joong-Ho Kim) 한국펄프·종이공학회 2012 한국펄프·종이공학회 학술발표논문집 Vol.2012 No.4
This study investigated softening effect of softwood chips according to different pulping conditions for CTMP. The amount of both sodium sulfite and sodium hydroxide played a vital role in softening wood chips. Pulping temperature was also a key factor to influence penetration of pulping liquor to wood chips.
Shim, Man Kyu,Park, Jooho,Yoon, Hong Yeol,Lee, Sangmin,Um, Wooram,Kim, Jong-Ho,Kang, Sun-Woong,Seo, Joung-Wook,Hyun, Soo-Wang,Park, Jae Hyung,Byun, Youngro,Kwon, Ick Chan,Kim, Kwangmeyung Elsevier 2019 Journal of controlled release Vol.294 No.-
<P><B>Abstract</B></P> <P>Cancer nanomedicine using nanoparticle-based delivery systems has shown outstanding promise in recent decades for improving anticancer treatment. However, limited targeting efficiency, low drug loading efficiency and innate toxicity of nanoparticles have caused severe problems, leaving only a few available in the clinic. Here, we newly developed carrier-free nanoparticles of cathepsin B-cleavable peptide (Phe-Arg-Arg-Gly; FRRG)-conjugated doxorubicin (DOX) prodrug (FRRG-DOX) that formed a stable nanoparticle structure with an average diameter of 213 nm in aqueous condition. The carrier-free nanoparticles of FRRG-DOX induced cytotoxicity against cathepsin B-overexpressed tumor cells whereas the toxicity was minimized in normal cells. In particular, the FRRG-DOX nanoparticles showed the successful tumor-targeting ability and enhanced therapeutic efficiency in human colon adenocarcinoma (HT-29) tumor-bearing mice <I>via</I> enhanced permeation and retention (EPR) effect. Furthermore, FRRG-DOX nanoparticles did not present any severe toxicity, such as non-specific cell death and cardiac toxicity, in normal tissues due to minimal expression of cathepsin B. This carrier-free nanoparticles of FRRG-DOX can solve the unavoidable problems of current nanomedicine, such as lower targeting efficiency, toxicity of nanoparticles themselves, and difficulty in mass production that are fatally caused by natural and synthetic nano-sized carriers.</P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>
급성 슬관절 손상에 동반되어 자기공명영상에 나타난 골멍(bone bruise)의 임상적 의의
심재웅,송무호,양승욱,정학영 대한슬관절학회 1996 대한슬관절학회지 Vol.8 No.2
The Magnetic resonance imaging(MRI) is accepted as a useful tool for the diagnosis of injury of the knee recently. The bone bruise is found on magnetic resonancc imaging as bone signal change that is not found on the simple radiograph. The bone bruise represents trabecular fractures, hemorrhage, and edema of the bone marrow without disruption of the cortex, and cannot be detected with conventional radiography. The criteria of decresed signal intensity on the T1 weighted image and increased signal intensity on the T2 weighted image were applied for the assessment of the bone bruise. From Jan. 1991 to Dec. 1995, MRI was performed on 78 patients with suspicious injury in meniscus or ligament structure of the knee. The bone bruises were documented in 22 of the 78 patients(28%) with suspicious ligament injury. Of the 22 patients with bone bruise, 80% had lesions of the lateral compartment. The most common associated ligament injury with bone bruise The medial collateral ligament(72%), and the next is the anterior cruciate ligament(41%). The most important consideration in bone bruise is an association with ligamentous injuries, and the detection of the bone bruise is very important in meticulous evaluation of ligamentous injuries.
( Ho Jeong Kwon ),( Dong Hoon Kim ),( Joong Sub Shim ),( Jong Woong Ahn ) 한국미생물 · 생명공학회 2002 Journal of microbiology and biotechnology Vol.12 No.4
Apicularen A (Api A) was recently isolated from Chondromyces sp. as a potent antitumor agent. Because of its unique chemical structure, a macrolide with a highly unsaturated amide side chain, and potent growth inhibitory effect in various cancer cell lines, Api A is currently in clinical trial for cancer therapy. In the present study, the effect of Api A on in vitro angiogenesis of bovine aortic endothelial cells (BAECs) was investigated. Api A potently inhibited the proliferation of BAECs in a dose-dependent manner. Treatment of the endothelial cells with up to 10 ng/ml of the compound did not show any cytotoxicity. In addition, it inhibited basic fibroblast growth factor (bFGF)-induced invasion and capillary tube formation of BAECs at concentrations of 2-5 ng/ml. These results, therefore, demonstrate that Api A is a novel antiangiogenic agent and may suppress the growth of tumors, at least in part, by the inhibition of neovascularization.
최웅기 ( Woong Ki Choi ),이규섭 ( Kyu Sop Lee ),정혜영 ( Hye Young Joung ),이영창 ( Young Chang Lee ),손진훈 ( Jin Hun Sohn ),이배환 ( Bae Hwan Lee ),변광호 ( Kwang Ho Pyun ),심인섭 ( In Sop Shim ) 한국감성과학회 2007 감성과학 Vol.10 No.3
저주파소음(low frequency noise; LFN)은 인체의 다양한 기관과 정신적 상태에 영향을 미치며, 진동음향질환(vibroacoustic disease; VAD)같은 질병들을 야기 시킨다. 이전의 연구에서는 인간 또는 설치류에서 VAD는 우울증 또는 불안장애와 같은 만성적인 정신 건강에 위험을 미친다고 보고되고 있다. 본 연구에서는 LFN이 스트레스의 신경생리적 반응에 미치는 영향을 규명하고자 하였다. 이를 위하여, LFN에 노출된 흰쥐에서 스트레스 반응에 중요한 역할을 하는 paraventricular nucleus of the hypothalamus(PVN)에서 초기발현유전자인 c-fos 양성세포 발현, locus coeruleus(LC)에서 NE 생성 효소인 tyrosine hydroxylase(TH) 양성세포 발현과 스트레스 호르몬의 농도를 측정하였다. LFN 집단은 각각 32.5Hz 와 125Hz를 하루에 4시간씩 이틀 동안 소음에 노출 하였으며, 정상집단은 소음에 노출되지 않도록 하였다. 저주파소음에 노출 후 집단 간 혈액내 코르티코스테론 분석과, 면역조직염색법을 이용하여 스트레스에 반응하는 PVN에서 c-fos발현과, LC에서 TH를 분석한 결과, PVN에서는 c-fos의 발현과 LC에서 TH의 발현이 증가됨을 관찰할 수 있었으며, 그리고 혈중 코르티코스테론의 농도 또한 LFN집단에서 높게 발현됨을 확인 하였다. 그리고 32.5Hz 보다 125Hz의 소음에서 면역염색반응과 코르티코스테론의 결과가 다소 높게 나타남을 알 수 있었다. 이러한 결과는 저주파소음에 의해 스트레스와 연관된 뇌의 부위에서 c-Fos와 TH의 발현이 증가됨을 증명하고 있다. 따라서 저주파소음은 일반적인 스트레스에 의한 반응과 비슷한 신경적 특징들을 보여주고 있다. 그리고 저주파소음에 의한 중추, 말초신경계의 활성화는 아마도 진동음향질환과 같은 행동장애 질병과 관련이 있을 것임을 시사한다. Exposure to low frequency noise(LFN) can lead to vibroacoustic diseases(VADs), which include a systemic disease with lesions in a broad spectrum of organs and a psychiatric condition. It is known that VAD is an established risk factor for the development of many psychological conditions in humans and rodents, including major depression and anxiety disorder. The present study investigated the effects of LFN on neuronal stress responses in the rat brain. The neuronal expression of the proto-oncogene c-fos in the paraventricular nucleus(PVN) of the hypothalamus and tyrosine hydroxylase(TH) in the LC was observed. The immunocytochemical detection of the Fos protein and TH has been used as a marker of neuronal activation in response to stress. In addition, corticosterone concentration was evaluated by using an enzyme-linked immunosorbent assay(ELISA) The LFN groups were exposed to 32.5Hz and 125Hz of noise(4hr/day for 2days). The numbers of c-fos and TH-immunoreactive cells in the PVN and LC were significantly increased in the LFN groups(32.5Hz and 125Hz) compared to the normal group. Corticosterone concentration in plasma was also increased in LFN groups. The present results demonstrated that exposure with LFN produced a pronounced increase in expression of c-Fos and TH in stress-relevant brain areas. These results suggest that the neural characteristics involved in LFN are similar to those activated by typical processive stressors. These results also suggest that the central and peripheral activations by LFN may be related to LFN-related negative behavioral dysfunctions such as VADs.
Identification of novel peptides that stimulate human neutrophils
Geon Ho Bae,이하영,정영수,Jae Woong Shim,김상두,백석환,권재영,박준성,배외식 생화학분자생물학회 2012 Experimental and molecular medicine Vol.44 No.2
Neutrophils play a key role in innate immunity, and the identification of new stimuli that stimulate neutrophil activity is a very important issue. In this study, we identified three novel peptides by screening a synthetic hexapeptide combinatorial library. The identified peptides GMMWAI, MMHWAM, and MMHWFM caused an increase in intracellular Ca2+ in a concentration-dependent manner via phospholipase C activity in human neutrophils. The three peptides acted specifically on neutrophils and monocytes and not on other non-leukocytic cells. As a physiological characteristic of the peptides, we observed that the three peptides induced chemotactic migration of neutrophils as well as stimulated superoxide anion production. Studying receptor specificity, we observed that two of the peptides (GMMWAI and MMHWFM) acted on formyl peptide receptor (FPR)1 while the other peptide (MMHWAM) acted on FPR2. Since the three novel peptides were specific agonists for FPR1 or FPR2, they might be useful tools to study FPR1- or FPR2-mediated immune response and signaling.
Jong-Ho Park,Young-Woong Byeon,Hye-Sun Kim,Yong-Uk Kim,Chang-Ki Shim,Min-Jeong Kim,Yong-Ki Kim 한국응용곤충학회 2018 한국응용곤충학회 학술대회논문집 Vol.2018 No.10
유기농경지에서 문제가 되는 해충을 방제하기 위하여 농가에서는 식물추출물 등 다양한 자가제조 유기농업자재를 활용하고 있다. 본 연구에서는 농가 자가제조 유기농업자재를 이용하여 목화진딧물(Aphis gossypii)과 꽃노랑총채벌레(Franklineilla occidentalis)에 대한 살충효과를 시험하였다. 유기농업자재는 유기재배 농가에서 직접 수집하였으며 식물추출물로는 마늘, 돼지감자, 은행잎 등의 식물추출물과 목초액, 식물오일 등 8종의 자재를 이용하였다. 해충에 대한 살충시험은 25℃, 60% 습도 조건의 곤충사육실에서 이루어졌다. 처리시험을 위해 오이절편을 페트리디쉬에 넣고 시험곤충을 접종하여 농가수집자재를 원액, 30배, 100배, 300배로 희석하여 충체 살포법으로 처리하였다. 처리 후 24시간, 36시간, 72시간 후 사충률을 조사하였다. 진딧물의 경우 100배 희석처리에서 약초액비가 75%, 유화오일이 62.5% 은행잎액비가 42.5%의 살충효과를 각각 보여주었다. 꽃노랑총채벌레에는 협죽도와 마늘이 94.7%와 88.0% 살충효과를 보여주었다.