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      • Thiocarbamyl Enoxacin 유도체의 합성 및 항균작용

        신화우,고무수,정동훈,최광식,임철부 원광대학교 식품약품안전성연구소 1991 食品藥品安全性硏究 Vol.4 No.-

        Treatment of 1-ethyl-6-fluoro-1, 4-dihydro-4-oxo-7-(1-piperazinyl)-1, 8-naphthyridine-3-carboxylic acid (Enoxacin) with alkyl(or aryl) isothiocyanates which obtained from alkyl(or aryl) amines afforded six 1-ethyl-6-fluoro-1, 4-dihydro-4-oxo-7-(1-alkylthiocarbamylpiperazinyl)-1, 8-naphthyridine-3-carboxylic acids and five 1-ethyl-6-fluoro-1, 4-dihydro-4-oxo-7-(1-arylthiocarbamyl piperazinyl)-1, 8-naphthyridine-3-carboxylic acids. The compounds synthesized were evaluated for their antimicrobial activities, in vitro, against Escherichia coli 6-PE-4, Bacillus subtilis 74-51, Proteus vulgaris 78645, Klebsiella pneumoniae JYA-78314, Staphylococcus aureus 79110 and Pseudomonas aeruginosa 8765-1 p_2.

      • 분편 인플루엔자백신(split influenza vaccine)의 임상효과 및 면역원성에 관한 연구

        우흥정,김동림,정희진,천병철,이주연,안정배,김지희,박찬,신영규,김우주,김민자,박승철 대한화학요법학회 1999 대한화학요법학회지 Vol.17 No.1

        목적 : 아단위 인플루엔자 백신 접종 후 백신의 인플루엔자 예방효과, 인플루엔자 방어 항체형성, 인플루엔자 백신의 안전성을 조사하고자 하였다. 방법 : 총 571명을 대상으로 인플루엔자 백신 접종을 하였고, 이들 접종자에서 인플루엔자 양질환의 이환을 조사하여 인플루엔자 백신의 인플루엔자예방효과를 알아보았고, 백신의 접종 전 및 접종 4주 후 혈청에서 혈구응집억제물(Hemagglutination Inhibition : HAI) 항체 검사를 실시하여 백신의 방어항체생성을 조사하였고, 백신의 안전성을 알아보기 위해 백신접종 후 1주일 이내의 부작용을 조사하였다. 결과 :백신 접종군과 백신 비접종군에서 인플루엔자 양 질환의 이환을 조사한 결과 접종군 28.35%, 비접종군 35.88%으로 나왔으며, p 값이 0.001로 통계적으로 접종군에서 유의하게 낮았고, 인플루엔자 양 질환의 예방 효과는 20.97%를 보였다. 백신의 방어항체 형성의 평가를 위해 유럽의 인플루엔자 백신 허가 기준을 조사하였는데 B/Guangdong/5/94균주의 백신접종 후 항체가 40이상의 비율을 제외한 다른 기준은 모두 만족 시켰다. 부작용은 전체 조사자 521명중 149명(29%)으로 주로 접종 부위의 국소 부작용을 호소했고, 전신 부작용은 2% 내외였으며 특별히 심각한 부작용은 발견되지 않았다. 결론 : 분편 인플루엔자 백신은 인플루엔자양질환의 예방과 방어항체생성에 효과 있으며 안전한 것으로 사료된다. Background : The safety and effectiveness of influenza vaccine are well known in developed country. The influenza vaccination has been recommended as one of the tentative immunization schedule for indicated persons since 1997 in Korea. But there are still no available data about them, even though nearly 5 million doses of influenza vaccine were used in 1997-1998 season. So it is immediately needed to investigate the safety. efficacy and immunogenicity of influenza vaccine among Korean. Methods : We studied the clinical efficacy of influenza vaccine by monitoring Occurrence of influenza-like illness in influenza risk group(vaccination ; 300, non-vaccination; 215) from December in 1997 to March in 1998. We used the split quadrivalent influenza vaccine containing 15 microgram of hemagglutinin of A/Beijing/262/95(HlNl), A/Wuhan/359/95(H3N2), B/Mie/1/93 and B/Guangdong/5/94. Hemagglutination inhibition(HA1) antibody titers were determined before immunization and 1 months after vaccination And we evaluated adverse effect of influenza vaccination at 7 days after vaccination. Results : Influenza vaccination was associated with si@icant reductions in influenza-like spptoms(vaccination group; 28.35%, non-vaccination group, 35.88%, p=0.001). The preventive effect of influenza-like i3lne.s among influenza risk goup was 20.97%. And immunogenicity of influenza A and B exceeded all of the European licensure criteria for immunogenicity except postvaccination proportion of titers 240 of B/Guangdong/5/94 strain. And the adverse effects were mainly local injection site problem and no serious adverse effect was noted. Conclusion : Split influenza vaccine is safe, inmunogenic and eff'tive in influenza risk group in Korea.

      • 하악 매복 지치의 외과적 발거시 Methylprednisolone의 안면 부종 감소 효과에 대한 임상적 연구

        신지훈,박진배,한지용,윤혜경,김우형,이희철 인제대학교 백병원 2002 仁濟醫學 Vol.23 No.4

        Objective : The third molars, expecially mandibular wisdom teeth, are commonly obliquely impacted, and surgical procedure with odontomy and osteotomy is necessary for their extraction. The surgical extracion of impacted wisdom teeth occasionally in duces variable discomfort. Especially, postoperative swelling, pain and limitation of mouth opening determine the degree of discomfort. For the reduction of these complicaions, drug therapy(antihistamine, enzyme, steroid), cole pack and pressure technique have been studied. It is known that the steroids are the most effective. Methods and Meterial : We selected fifty patients in their twenties, who visited Department of Dentistry, Pusan Paik Hospital from March to August in 1998. All of 50 patients has no other medical problems. Total 50 patients were randomly divided to 30 of experimental group and 20 of control group. The experimental group had orally administration of methyprednisolone 5㎎ every 8 hours 2 times preoperatively and 7 times postoperatively. Five points were marked on the patients' face, and the distances between the points were measured just before operation and 48 hours after operation. Results : Methyprednisolone reduces swelling about 50% after surgical extraction of obliquely impacted mandibular third molars with osteotomy and odontomy. The difference in the amount of tissue edema between experimental and control group was significant(p<0.01). However, there was no significant difference according to the operation time. Conclusion : It seems that the use of methylprednisolone is effective to reduce postoperative swelling following surgical extraction of third molars.

      • KCI등재

        근저항 트레이닝이 20대 여성의 신체조성과 체력에 미치는 영향

        이상우,김봉환,서해근,강신범,나재철 대한스포츠의학회 1999 대한스포츠의학회지 Vol.17 No.1

        The purpose of this study was to investigate the effect of muscular resistance training on the body composition and the physical fitness. The subjects of study were 6 women in their twenties who had not taken will in ordinary days and had not gone through regular training. The above subjects were measured by body composition and physical fitness pre and post 8 weeks training. The frequence training was more than 4 times a week and the duration of training of each session was 70 miniutes. The results are as fallows: 1. In muscular resistance training for 8 weeks, % Fat 1.8%(7.76%), and Fat weigh 3.0kg(23.43%), wee decreased, while LBM 3.0kg(7.10%) was increased, However, there was no differences. 2. In muscular resistance training for 8 weeks, it was exposed to be increased a little in Left arm strength 2.65kg(9.60%), Fight arm strength 2.03kg(7.78%), Left leg extention strength 12.47kg(6.16%), Right leg extention strength 4.50kg(2.35%), Left leg flextion strength 13.67kg(13.01%), Right leg flextion strength 13.25kg(12.70%), Standing trunk flextion 3.25㎝(18.16%), Front split 2.67㎝(1.65%), Side step 3.83friq(11.16%), Vital capacity 5.02cc(0.22%).

      • KCI등재

        서울시 교직원 당뇨병의 역학적 특성 및 관련위험요인분석

        이희우,김종희,장철환,신선미 韓國學校保健學會 2004 韓國學校保健學會誌 Vol.17 No.1

        Purpose : To describe the prevalence, epidemiological characteristics, and related factors of diabetes mellitus in school personnel. Method : 5,384 school personnel (2,638 males 2,746 females) received physical examinations at the Seoul School Health Center in Z 2. Using the American Diabetes Association criteria, and fasting blood sugar(FBS) was classified as normal at 110>=FBS, borderline 111-125, and the diabetes group 126<=FBS. Related factors of each group were evaluated by gender. Results : In the diabetes group, there were 4.74% males and 0.8% females, and the borderline group was 6.37% males and 2.22% females. The older age group gad a higher distribution in both males and females in the diabetes group. In the diabetes group, the mean and abnormal rate of BMI, systolic hypertension, diastolic hypertension, total cholesterol, GOT, GPT, and GTP were higher than in the normal group. In life style factor, the diabetes group gad a higher distribution of meat eating and smoking more than 20 years than the normal group. The effect of FBS on BMI, BP(blood pressure), total cholesterol, GOT, GPT, and GTP were investigated after controlling for confounding variables. In the borderline and diabetes group, the mean of BMI, BP, total cholesterol, GOT, GFT, and GTP was higher in dose-response effect. In the logistic multiple regression, the related factors of the diabetes group were hypertension and abnormal GTP in males, and abnormal total cholesterol and GTP in females. In the borderline group, the related factors were meat eating, hypertension, and high GOT in males and the older age group, and hypertension, total cholesterol, and abnormal GTP in females. Conclusions : It is possible to manage all related factors of diabetes mellitus except for age. An appropriate program for health promotion is necessary.

      • 男ㆍ女 中學生의 體格 GROUP別 發育樣相에 對한 縱斷的 硏究

        이상우,신상근,안기영,강신범,나재철 東亞大學校附設스포츠科學硏究所 1996 스포츠科學硏究論文集 Vol.14 No.-

        The purpose of this study was examine each group's growth type of the middle school syudents through three year's individual follow-measurement. Subject were 1110(male = 558, female = 552) who were living in Tea-gu. 1. In the whole means of each item the growth of rate of male for female in height and the sitting height was 2.9 and that of the weight and the girth of chest was 1.7. 2. The growth volume of the height, the sitting height was commonly anti-proportional in male and female. 3. The weight of male was revealed the similar growth between groups except 6,7 group. And that of female revealed the small decreasing phenomenon in 4 - 7 groups at 4,5 times. 4. The growth volume of the girth of chest was revealed highest in 2 group. Smallest in 6 group of male. And that was revealed the decreasing phenomenon in 6 group of female since 4 times.

      • 南·北韓 國史敎科書(중학교)의 比較硏究

        康宇哲,申瀅植 이화여자대학교 한국문화연구원 1990 韓國文化硏究院 論叢 Vol.57 No.-

        This research is conducted to study the difference of current National history textbooks for secondary schools in South and North Korea. It is found that there is a great difference, particularly, in the description of the periodization and main items. The National history textbook in North Korea puts great importance on the struggle of people and takes aim at training communistic revolutionists who are devoted to building up the socialist state and to Kim, Il-sung. Doing so, they removed, distorted and fabricate the facts that are not suitable for this aim without hesitation. Consequently they explain the Buddism and the Confucianism as the opiums which paralyze the struggle consciousness. On the contrary our textbook takes aim at the objective description of the historical facts and undistorted understanding of our culture that contribute to the world peace and human progress in civilization. We focus on the training of true account of history by means of evaluation and criticism on the basic of accurate understanding of "facts as facts". Above all, the textbook in North Korea focuses solely on the struggle, and the national history is used to build up the cult of idolizing one individual Kim, Il-sung. Accordingly, we must confirm the distortion and illegitimacy of the textbook in North Korea and make every effort on the restoration of homogeneity as one nation on the basis of rightful understanding of the historical facts.

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