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Microfluidic-based cell handling devices for biochemical applications
Lee, Sanghyun,Kim, Hojin,Lee, Wonhyung,Kim, Joonwon IOP 2018 Journal of micromechanics and microengineering Vol.28 No.12
<P>Microfluidic-based cell handling techniques have become promising tools for biochemical applications, and many such techniques have been developed with the advancement of microfabrication technologies. A microfluidic-based platform used for biochemical analysis offers numerous benefits, including small sample consumption, massive parallelization, rapid analysis, and the capability for single-cell analysis, which are difficult to achieve in conventional cell handling methods on a large scale. It also exhibits precise spatial and temporal control of the local cellular microenvironments based on microfluidic networks in accordance to the unique fluidic phenomena of microfluidics. This review focuses on various cell handling methods that take advantage of microfluidics by classifying them in accordance to specific functions required for biochemical analyses, including (i) cell transfer, (ii) cell separation and sorting, (iii) cell immobilization, (iv) cell isolation and encapsulation, and (v) cell retrieval.</P>
Zhang, Enji,Lee, Sunyeul,Yi, Min-Hee,Nan, Yongshan,Xu, Yinshi,Shin, Nara,Ko, Youngkwon,Lee, Young Ho,Lee, Wonhyung,Kim, Dong Woon SPANDIDOS PUBLICATIONS 2017 MOLECULAR MEDICINE REPORTS Vol.16 No.2
<P>In previous studies that have profiled gene expression in patients with complex regional pain syndrome (CRPS), the expression of granulocyte colony-stimulating factor 3 receptor (G-CSFR) was elevated, as were a number of pain-associated genes. The present study determined the expression of G-CSFR and the mechanisms by which it may affect hypersensitivity, focusing on the signal transducer and activator of transcription 3 (STAT3)/transient receptor potential cation channel subfamily V 1 (TRPV1) signaling pathway in particular, which is an important mediator of pain. Following L5 spinal nerve ligation (SNL) surgery, the protein and mRNA levels of G-CSFR increased in the ipsilateral spinal dorsal horn when compared with the sham and/or contralateral control. Double immunofluorescence further demonstrated that G-CSFR colocalized with TRPV1 and phosphorylated STAT in the neurons of the spinal dorsal horn. G-CSF treatment led to an increase in G-CSFR and TRPV1 expression and phosphorylation of STAT3. These results indicate that G-CSF-induced G-CSFR expression may activate TRPV1 by promoting phosphorylation of STAT3. Collectively, the results suggest, for the first time, that the expression of G-CSFR in neurons following peripheral nerve injury may be involved in the induction and maintenance of neuropathic pain through the STAT3 and TRPV1 signaling pathway.</P>
국내외 클라우드 보안 정책 비교를 통한 보안 강화 연구
이상웅(Sangwoong Lee),박문형(Moonhyung Park),이선아(Seon-a Lee),박원형(Wonhyung Park) 한국정보통신학회 2021 한국정보통신학회 종합학술대회 논문집 Vol.25 No.2
최근 코로나19 팬데믹 이후로 인터넷 사용량이 급증하고 기업들은 재택근무로 변화되면서 온프라미스 환경에서 빠르게 클라우드 환경으로 전환 되었다. 또한, 집에 있는 시간이 많아지고 게임이나 인터넷, 넷플렉스 등 스트리밍 서비스를 통한 네트워크 트래픽 급증과 동시에 사이버공격이나 위협들도 많아 지고 있다. 우리나라를 포함한 미국, EU, 일본 등 세계 여러나라에서는 다양한 클라우드 보안 정책을 가지고 있으나 다양한 취약점과 사이버공격 등으로 피해를 지속 당하고 있다. 본 논문은 현재 각 나라의 클라우드 보안 정책을 분석하여 우리나라 클라우드 보안 정책을 강화 하는 방안을 제시한다. Since the recent COVID-19 pandemic, Internet usage has increased rapidly and companies have shifted to telecommuting. In addition, as more time at home increases and network traffic through streaming services such as games, the Internet, and Netflix increases, cyberattacks and threats are also increasing. Many countries around the world, including Korea, the US, China, and Japan, have various cloud security policies, but they continue to suffer from various vulnerabilities and cyberattacks. This paper analyzes the current cloud security policies of each country and presents a plan to strengthen the cloud security policies in Korea.